2004
DOI: 10.1002/art.20358
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Dissection of class III major histocompatibility complex haplotypes associated with rheumatoid arthritis

Abstract: Objective. We have previously identified a singlenucleotide polymorphism (SNP) haplotype involving the lymphotoxin ␣ (LTA) and tumor necrosis factor (TNF) loci (termed haplotype LTA-TNF2) on chromosome 6 that shows differential association with rheumatoid arthritis (RA) on HLA-DRB1*0404 and *0401 haplotypes, suggesting the presence of additional non-HLA-DRB1 RA susceptibility genes on these haplotypes. To refine this association, we performed a case-control association study using both SNPs and microsatellite … Show more

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Cited by 54 publications
(37 citation statements)
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“…Indeed, there is previous evidence that genes within the central MHC also contribute to disease risk, independent of DRB1. 10,11,48 The current data suggest that additional risk genes may also lie within the very broad linkage peak in this region, perhaps some of which lie outside of the MHC proper.…”
Section: Discussionmentioning
confidence: 65%
“…Indeed, there is previous evidence that genes within the central MHC also contribute to disease risk, independent of DRB1. 10,11,48 The current data suggest that additional risk genes may also lie within the very broad linkage peak in this region, perhaps some of which lie outside of the MHC proper.…”
Section: Discussionmentioning
confidence: 65%
“…Class II molecules are found on APCs and govern presentation of antigens to CD4+ T cells. RA susceptibility is associated with specific alleles within MHC class II, namely HLA DRB1 (Newton et al, 2004a;Newton et al, 2004b). The frequency of HLA DRB1 alleles is increased in patients with RA when compared to healthy controls (McInnes and Schett, 2007).…”
mentioning
confidence: 99%
“…While we did not eliminate a role for HLA-DQB1*0302, a gene in the central MHC would explain our data. A central MHC effect contributing to susceptibility to T1DM has been described in HLA-DRB1*0404 patients 14 and HLA-DRB1*0301 patients. [6][7][8] Here IKBL þ 446*T and HLA-A2,B15 were used as haplotypic markers to identify an interactive effect between the class II alleles and the telomeric portion of the 62.1AH.…”
Section: Discussionmentioning
confidence: 99%