Dissecting the Mechanisms of the Clock in Neurospora

Hurley, Jennifer M.; Loros, Jennifer J.; Dunlap, Jay C.

doi:10.1016/bs.mie.2014.10.009

Cited by 39 publications

(38 citation statements)

References 95 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…WC-1 and WC-2 interact via PAS domains and drive the expression of a salient protein in the negative arm of the clock, Frequency (FRQ) (reviewed in (Fuller et al, 2014; Hurley et al, 2015). FRQ binds to its partner protein Frequency Interacting RNA Helicase (FRH) immediately upon translation and this interaction stabilizes FRQ, as FRQ is an Inherently Disordered Protein (IDP) and is intrinsically unstable absent a partner (Cheng et al, 2005; Guo et al, 2009; Hurley et al, 2013; Querfurth et al, 2011; Shi et al, 2010; Zhou et al, 2013).…”

Section: Circadian Clocks In Fungimentioning

confidence: 99%

The circadian system as an organizer of metabolism

Hurley

Loros

Dunlap

2016

Fungal Genetics and Biology

Self Cite

View full text Add to dashboard Cite

The regulation of metabolism by circadian systems is believed to be a key reason for the extensive representation of circadian rhythms within the tree of life. Despite this, surprisingly little work has focused on the link between metabolism and the clock in Neurospora, a key model system in circadian research. The analysis that has been performed has focused on the unidirectional control from the clock to metabolism and largely ignored the feedback from metabolism on the clock. Recent efforts to understand these links have broken new ground, revealing bidirectional control from the clock to metabolism and vise-versa, showing just how strongly interconnected these two cellular systems can be in fungi. This review describes both well understood and emerging links between the clock and metabolic output of fungi as well as the role that metabolism plays in influencing the rhythm set by the clock.

show abstract

Section: Circadian Clocks In Fungimentioning

confidence: 99%

The circadian system as an organizer of metabolism

Hurley

Loros

Dunlap

2016

Fungal Genetics and Biology

Self Cite

View full text Add to dashboard Cite

show abstract

“…We recommend to readers other excellent reviews on Neurospora circadian clocks for a more comprehensive description (Dunlap & Loros, 2017; C. Heintzen & Liu, 2007; J. Hurley, Loros, & Dunlap, 2015; Lakin-Thomas, Bell-Pedersen, & Brody, 2011).…”

Section: The Circadian Clock Of Neurosporamentioning

confidence: 99%

“…(Baker et al, 2012; P. Cheng, Y. Yang, K. H. Gardner, & Y. Liu, 2002; Dunlap & Loros, 2017; J. Hurley et al, 2015).…”

Section: The Circadian Clock Of Neurosporamentioning

confidence: 99%

“…He, L. Wang, & Y. Liu, 2005; Guo, Cheng, & Liu, 2010). Upon localization of FFC into the nucleus, several kinases interact with the FFC complex to phosphorylate FRQ (Baker et al, 2012; J. Hurley et al, 2015).…”

Section: The Circadian Clock Of Neurosporamentioning

confidence: 99%

“…The low level of FRQ in the nucleus allows WCC in the nucleus to resume transcription of frq , which closes the negative feedback loop. The period of circadian oscillation of the clock gene FRQ is about 22 h, which includes the time for synthesis, phosphorylation, and degradation of the FRQ protein (Dunlap & Loros, 2017; J. Hurley et al, 2015; M.…”

Section: The Circadian Clock Of Neurosporamentioning

confidence: 99%

See 2 more Smart Citations

Natural Variation of the Circadian Clock in Neurospora

Koritala

Lee

2017

Natural Variation and Clocks

View full text Add to dashboard Cite

Most living organisms on earth experience daily and expected changes from the rotation of the earth. For an organism, the ability to predict and prepare for incoming stresses or resources is a very important skill for survival. This cellular process of measuring daily time of the day is collectively called the circadian clock. Because of its fundamental role in survival in nature, there is a great interest in studying the natural variation of the circadian clock. However, characterizing the genetic and molecular mechanisms underlying natural variation of circadian clocks remains a challenging task. In this chapter, we will summarize the progress in studying natural variation of the circadian clock in the successful eukaryotic model Neurospora, which led to discovering many design principles of the molecular mechanisms of the eukaryotic circadian clock. Despite the success of the system in revealing the molecular mechanisms of the circadian clock, Neurospora has not been utilized to extensively study natural variation. We will review the challenges that hindered the natural variation studies in Neurospora, and how they were overcome. We will also review the advantages of Neurospora for natural variation studies. Since Neurospora is the model fungal species for circadian study, it represents over 5 million species of fungi on earth. These fungi play important roles in ecosystems on earth, and as such Neurospora could serve as an important model for understanding the ecological role of natural variation in fungal circadian clocks.

show abstract

Circadian processes in the RNA life cycle

et al. 2018

View full text Add to dashboard Cite

The circadian clock drives daily rhythms of multiple physiological processes, allowing organisms to anticipate and adjust to periodic changes in environmental conditions. These physiological rhythms are associated with robust oscillations in the expression of at least 30% of expressed genes. While the ability for the endogenous timekeeping system to generate a 24-hr cycle is a cell-autonomous mechanism based on negative autoregulatory feedback loops of transcription and translation involving core-clock genes and their protein products, it is now increasingly evident that additional mechanisms also govern the circadian oscillations of clock-controlled genes. Such mechanisms can take place post-transcriptionally during the course of the RNA life cycle. It has been shown that many steps during RNA processing are regulated in a circadian manner, thus contributing to circadian gene expression. These steps include mRNA capping, alternative splicing, changes in splicing efficiency, and changes in RNA stability controlled by the tail length of polyadenylation or the use of alternative polyadenylation sites. RNA transport can also follow a circadian pattern, with a circadian nuclear retention driven by rhythmic expression within the nucleus of particular bodies (the paraspeckles) and circadian export to the cytoplasm driven by rhythmic proteins acting like cargo. Finally, RNA degradation may also follow a circadian pattern through the rhythmic involvement of miRNAs. In this review, we summarize the current knowledge of the post-transcriptional circadian mechanisms known to play a prominent role in shaping circadian gene expression in mammals. This article is categorized under: RNA Processing > Splicing Regulation/Alternative Splicing RNA Processing > RNA Editing and Modification RNA Export and Localization > Nuclear Export/Import.

show abstract

Dissecting the Mechanisms of the Clock in Neurospora

Cited by 39 publications

References 95 publications

The circadian system as an organizer of metabolism

The circadian system as an organizer of metabolism

Natural Variation of the Circadian Clock in Neurospora

Circadian processes in the RNA life cycle

Contact Info

Product

Resources

About