“…Upon interaction with a lipid membrane containing SM ( b ), their N-terminal α-helix stretch is detached and extended, shortly laying parallel to the membrane ( c ) [ 25 , 26 , 82 , 85 , 87 , 91 , 116 , 140 , 141 , 142 , 143 ]. Then, monomers oligomerize and insert this N-terminal α-helix, now about 30 residues long, within the hydrophobic membrane core ( d ) [ 34 , 144 , 145 , 146 , 147 , 148 , 149 ]. The existence of such an intermediate is one of the most controversial issues, depending on the degree of acceptance of the evidence about the real existence, or not, of pre-pore assemblies [ 132 , 133 , 150 ].…”