“…Thus, it is possible that structural disruptions promote sequencespecific interactions of the dsRBDs of ADARs in either the major or minor groove. Fascinatingly, it is observed that editing at an AU base-pair, which creates an IU mismatch and thus another structural disruption, propagates the effect by also enhancing editing at a distance, leading to a reiterative model for ADAR editing (Uzonyi et al, 2021;Zambrano-Mila et al, 2023). Not surprisingly, editing of A:C mismatches, which restore basepairing, do not propagate additional editing sites.…”