Dissecting pain processing in adolescents with Non‐Suicidal Self Injury: Could suicide risk lurk among the electrodes?

Leone, C.; Galosi, Serena; Mollica, Cristina; Fortunato, Mattia; Possidente, Chiara; Milone, V.; Misuraca, Sofia; Berillo, Luana; Truini, Andrea; Cruccu, G.; Ferrara, Mauro; Terrinoni, Arianna

doi:10.1002/ejp.1793

Cited by 7 publications

(5 citation statements)

References 89 publications

(124 reference statements)

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“…This is consistent with previous study, as Zhou et al (2022) used oddball paradigm to compare the differences of P3b components among NSSI + MDD, MDD and HC groups. Leone et al (2021) used laser evoked potential as an index to study the suicide risk of NSSI adolescents suggest that the amplitude of N2 component in NSSI patients is reduced, which is different from our study, may be due to different experimental paradigms. In this study, no significant difference was found in the latency of N1 between the two groups, which was different from Wen’s study ( Wen et al, 2021 ).…”

Section: Discussioncontrasting

confidence: 99%

Prefrontal cortex neural activity predicts reduction of non-suicidal self-injury in adolescents with major depressive disorder: An event related potential study

et al. 2022

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BackgroundNon-suicidal self-injury (NSSI) is common in adolescent MDD, which is also a risk factor for suicide. However, there is few research on biomarkers and predictors about treatment response of NSSI. The purpose of this study was to find the difference of P300 between adolescent MDD with NSSI and healthy controls, and to explore whether the baseline electrophysiological level can predict the change of NSSI after treatment.MethodsWe collected 62 first-episode drug-naïve MDD adolescents with NSSI (MDD with NSSI group) and 44 healthy controls (HC group). The demographic data, HAMD score, self-injury frequency and electrophysiological level of NSSI group and HC group were collected. The HAMD score, frequency of NSSI in was also collected after 8 weeks of antidepressant treatment.ResultsCompared to HC, the latency of the N2, P3a, and P3b components were significantly prolonged, whereas the amplitude of P3a and P3b were decreased in the MDD with NSSI group (P < 0.001). The frequency of self-injury decreased significantly after treatment (P < 0.001). Regression analysis showed that the amplitudes of P3b had a significant positive predictive effect on the rate of change of NSSI frequency after 8 weeks.ConclusionP3b at baseline can be used as potential predictor for the reduction of NSSI in adolescent MDD.

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Section: Discussioncontrasting

confidence: 99%

Prefrontal cortex neural activity predicts reduction of non-suicidal self-injury in adolescents with major depressive disorder: An event related potential study

et al. 2022

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“…They were included if they were right‐handed, 22 drug‐naive, had not received cognitive behavioural treatments designed to address NSSI, had a normal cognitive profile (full‐scale IQ ≥ 70, measured using the Wechsler Intelligence Scale for Children), and had a normal or corrected‐to‐normal vision. Adolescents were excluded if they presented organic diseases, schizophrenia, or autism spectrum disorder 23 . Impulsivity was evaluated using (1) the UPPS‐P Impulsive Behavior Scale and (2) the Barratt Impulsiveness Scale Version 11.…”

Section: Methodsmentioning

confidence: 99%

“…Adolescents were excluded if they presented organic diseases, schizophrenia, or autism spectrum disorder. 23 Impulsivity was evaluated using (1) the UPPS-P Impulsive Behavior Scale and (2) the Barratt Impulsiveness Scale Version 11. The Multi-Attitude Suicide Tendency Scale and Difficulties in Emotion Regulation Scale were used to assess suicidal tendencies and emotion regulation disorder, respectively.…”

Section: Participantsmentioning

confidence: 99%

Enhanced reactive inhibition in adolescents with non‐suicidal self‐injury disorder

Mirabella,

Mancini,

Pacifici

et al. 2023

Develop Med Child Neuro

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AimTo investigate whether the core of the pathophysiology underlying non‐suicidal self‐injury (NSSI) relates to poor impulse control due to impaired motor inhibition (i.e. the ability to inhibit a preplanned motor response).MethodWe conducted a case–control study to compare the proficiency of two domains of motor inhibition, that is, reactive and proactive inhibition, by giving the reaching arm version of the stop‐signal task and a go‐only task to 28 drug‐naive adolescents with NSSI disorder (NSSID) (mean age [SD] 15 years 8 months [1 year 4 months]; three males and 25 females) and 28 typically developing adolescents (mean age 15 years 8 months [1 year 5 months]; three males and 25 females).ResultsReactive inhibition, as determined by the duration of the stop‐signal reaction time, was enhanced in adolescents with NSSID compared to typically developing controls (194.2 [22.5 ms] vs 217.5 [17.3 ms], p < 0.001). By contrast, proactive inhibition was similar in both groups. Lastly, the level of impulsivity, assessed using the Barratt Impulsiveness Scale Version 11, did not differ between typically developing adolescents and adolescents with NSSID. However, adolescents with NSSID were more impulsive than controls in a subscale of the UPPS‐P Impulsive Behavior Scale.InterpretationNSSID is not driven by heightened motor impulsivity. Instead, adolescents with NSSID exhibited greater proficiency in reactive inhibition, a proxy for motor impulsivity. We suggest that the enhancement of reactive inhibition strengthens action control, allowing adolescents to suppress their self‐protection instinct and perform NSSI behaviours.

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“…A red helium-neon (He-Ne) laser confocal with the infrared beam was used to visually indicate the irradiated area. Stimulus energy was fixed at 2 times the perception threshold of warmth on the control side, determined by the method of levels [23], and remained between 34 mJ/mm 2 and 39.6 mJ/mm 2 , which correspond to a stimulation energy of 6 6 to 7 Joules, applied to a skin circle of 15 mm diameter. These parameters allow activating C-warm fibers without concomitant excitation of Aδ axons, and elicit a subjective sensation of 'slow warmness' on normal skin [11,46].…”

Section: -Laser Radiant Innocuous Heat (Stimulation Of C-warmth Fibers)mentioning

confidence: 99%

Sympathetic skin response as an objective tool to estimate stimulus-associated arousal in a human model of hyperalgesia

Salameh

Perchet

Hagiwara

et al. 2022

Neurophysiologie Clinique

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Dissecting pain processing in adolescents with Non‐Suicidal Self Injury: Could suicide risk lurk among the electrodes?

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 7 publications

References 89 publications

Prefrontal cortex neural activity predicts reduction of non-suicidal self-injury in adolescents with major depressive disorder: An event related potential study

Prefrontal cortex neural activity predicts reduction of non-suicidal self-injury in adolescents with major depressive disorder: An event related potential study

Enhanced reactive inhibition in adolescents with non‐suicidal self‐injury disorder

Sympathetic skin response as an objective tool to estimate stimulus-associated arousal in a human model of hyperalgesia

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