Dissecting lipid raft facilitated cell signaling pathways in cancer

Patra, Samir Kumar

doi:10.1016/j.bbcan.2007.11.002

Cited by 218 publications

(274 citation statements)

References 252 publications

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“…These lipid-based organizational platforms, enriched in glycosphingolipids and cholesterol, are located in plasma membranes and have been implicated in a number of biological functions including membrane trafficking and signal transduction (Simons and Ikonen 1997;Hanzal-Bayer and Hancock 2007;Patra 2008). Interestingly, Multhoff and colleagues have recently shown that surface Hsp70 on human tumor cells interacts with globotriaosylceramide (Gb3), a glycosphingolipid associated with lipid rafts.…”

Section: Discussionmentioning

confidence: 99%

Monoclonal antibody to novel cell surface epitope on Hsc70 promotes morphogenesis of bile ducts in newborn rat liver

Mills

Haskell

Callanan

et al. 2010

Cell Stress and Chaperones

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Section: Discussionmentioning

confidence: 99%

Monoclonal antibody to novel cell surface epitope on Hsc70 promotes morphogenesis of bile ducts in newborn rat liver

Mills

Haskell

Callanan

et al. 2010

Cell Stress and Chaperones

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“…In addition to endocytosis, disruption of lipid rafts affects resveratrol-induced activation of downstream pathways, including kinase activation and cell death by caspase-3-mediated apoptosis. Interestingly, resveratrol seems to promote the redistribution of kinases, including ERKs and JNKs, in the lipid rafts, which may facilitate their activation and downstream induction of apoptosis (9,24,(39)(40)(41).…”

Section: Discussionmentioning

confidence: 99%

Endocytosis of Resveratrol via Lipid Rafts and Activation of Downstream Signaling Pathways in Cancer Cells

Colin

Limagne²,

Jeanningros³

et al. 2011

Cancer Prevention Research

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trans-Resveratrol has been proposed to prevent tumor growth and to sensitize cancer cells to anticancer agents. Polyphenol entry into the cells has remained poorly understood. Here, we show that [ 3 H]-resveratrol enters colon cancer cells (SW480, SW620, HT29) and leukemia U937 cells through a monensin (5-20 mmol/L) -sensitive process that suggests clathrin-independent endocytosis. Uptake of the molecule can be prevented by methyl-b-cyclodextrin (2-12 mg/mL), nystatin (12 ng/mL), and filipin (1 mg/mL), which all disrupt plasma membrane lipid rafts. Accordingly, radiolabeled resveratrol accumulates in sphingomyelin-and cholesterol-enriched cell fractions. Interestingly, extracellular signalregulated kinases (ERK), c-Jun NH 2 -terminal kinases (JNK), and Akt also accumulate in lipid rafts on resveratrol exposure (IC 50 at 48 h % 30 mmol/L in SW480 and U937 cells). In these rafts also, resveratrol promotes the recruitment, by the integrin a V b 3 (revealed by coimmunoprecipitation with an anti-integrin a V b 3 antibody), of signaling molecules that include the FAK (focal adhesion kinase), Fyn, Grb2, Ras, and SOS proteins. Resveratrol-induced activation of downstream signaling pathways and caspase-dependent apoptosis is prevented by endocytosis inhibitors, lipid raft-disrupting molecules, and the integrin antagonist peptide arginine-glycine-aspartate (500 nmol/L). Altogether, these data show the role played by lipid rafts in resveratrol endocytosis and activation of downstream pathways leading to cell death.

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“…157 Recent data on the proteomics of lipid rafts/caveolae have highlighted the enigmatic role of various signaling proteins in cancer development. 155 These data suggest a possible mechanism by which ceramide may exerts its anti-cancerous effect by being involved in cell signaling, that when dysregulated promotes cell transformation and tumor progression alterion. 155 Ceramide and insulin resistance Ceramide as well as other sphingolipids may be relevant in several cellular events associated with diabetes and cardiovascular disease, including insulin resistance, pancreatic b-cell failure, cardiomyopathy and vascular dysfunction.…”

Section: Potential Role For Ceramidementioning

confidence: 91%

“…153 The dynamicity of cell membrane plays some vital roles in cell survival and cell death, including protection, endocytosis, signaling and increases in mechanical stability during cell division, and cell separation from tissues for cancer metastasis. 155 Ceramide and cancer There is extensive evidence supporting the pivotal role of ceramide in cancer biology, 156 making it an attractive target for anticancer drug development within the sphingolipid metabolic pathway. Its function in apoptosis is best characterized.…”

Section: Potential Role For Ceramidementioning

confidence: 99%

Glucocerebroside: an evolutionary advantage for patients with Gaucher disease and a new immunomodulatory agent

2009

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Gaucher disease (GD) is caused by the reduced activity of a lysosomal enzyme, glucocerebrosidase, leading to the accumulation of glucocerebroside (GC). The relatively high prevalence of this disease within an ethnic group is believed to reflect a selective advantage. Treatment with enzyme replacement therapy (ERT) is safe and effective in ameliorating the primary symptoms of the disease, yet there have been reports that some patients on ERT have developed type 2 diabetes or metabolic syndrome, malignancies and central nervous system disorders. A series of animal studies suggest that these complications may be related to the reduction of GC levels by the enzyme administered. GC has been shown to have an immunomodulatory effect through the promotion of dendritic cells, natural killer T cells, and regulatory T cells. The break down of GC to ceramide can underline part of these findings. Clinical trials suggested a beneficial effect of GC in type 2 diabetes or nonalcoholic steatohepatitis. This review of the data from animal models and humans proposes that the increased level of GC may provide an evolutionary advantage for patients with GD. Indirectly, these data support treating symptomatic patients with mild/moderate GD with lowdose ERT and re-evaluating the use of ERT in asymptomatic patients.

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Dissecting lipid raft facilitated cell signaling pathways in cancer

Cited by 218 publications

References 252 publications

Monoclonal antibody to novel cell surface epitope on Hsc70 promotes morphogenesis of bile ducts in newborn rat liver

Monoclonal antibody to novel cell surface epitope on Hsc70 promotes morphogenesis of bile ducts in newborn rat liver

Endocytosis of Resveratrol via Lipid Rafts and Activation of Downstream Signaling Pathways in Cancer Cells

Glucocerebroside: an evolutionary advantage for patients with Gaucher disease and a new immunomodulatory agent

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