Dissecting glial scar formation by spatial point pattern and topological data analysis
Daniel Manrique-Castano,
Dhananjay Bhaskar,
Ayman ElAli
Abstract:Glial scar formation represents a fundamental response to central nervous system (CNS) injury. It is mainly characterized by a well-defined spatial rearrangement of reactive astrocytes and microglia. The mechanisms underlying glial scar formation have been extensively studied, yet quantitative descriptors of the spatial arrangement of reactive glial cells remain limited. Here, we present a novel approach using point pattern analysis (PPA) and topological data analysis (TDA) to quantify spatial patterns of reac… Show more
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