2020
DOI: 10.1021/acsomega.0c01494
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Dissecting Chemical Composition and Cardioprotective Effects of Fuzhengkangfu Decoction against Doxorubicin-Induced Cardiotoxicity by LC–MS and Bioinformatics Approaches

Abstract: Cardiotoxicity of doxorubicin (DOX) has gained increasing attention in clinical application. Fuzhengkangfu (FZK) decoction, a traditional Chinese herbal formula of replenishing Qi strengthening spleen, has been used to treat various cardiovascular diseases. However, the chemical composition, the protective effects of FZK, and the underlying mechanisms are yet unclear. In this study, an high-performance liquid chromatography−mass spectrometry (HPLC−MS) analytical method was established for the structural identi… Show more

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Cited by 12 publications
(10 citation statements)
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“…Our previous study shows that the chemical composition of DSELD has anti-inflammatory properties and evaluates its cardioprotective effects and antiapoptotic potentials in H9C2 cells ( Zhong et al, 2020 ). In this work, comprehensive in vitro and in vivo experiments are conducted to investigate the mechanisms by which DSELD exerts its antihypertrophic properties.…”
Section: Discussionmentioning
confidence: 99%
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“…Our previous study shows that the chemical composition of DSELD has anti-inflammatory properties and evaluates its cardioprotective effects and antiapoptotic potentials in H9C2 cells ( Zhong et al, 2020 ). In this work, comprehensive in vitro and in vivo experiments are conducted to investigate the mechanisms by which DSELD exerts its antihypertrophic properties.…”
Section: Discussionmentioning
confidence: 99%
“…The ingredients of DSELD described previously were provided by the Hangzhou First People’s Hospital (Hangzhou, China) ( Zhong et al, 2020 ). Its composition is shown in Table 1 .…”
Section: Methodsmentioning
confidence: 99%
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