Dissecting cell‐type‐specific pathways in medial entorhinal cortical‐hippocampal network for episodic memory

Osanai, Hisayuki; Nair, Indrajith R.; Kitamura, Takashi

doi:10.1111/jnc.15850

Cited by 4 publications

(17 citation statements)

References 320 publications

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“…It has been considered that the superficial layers (II/III) of EC mainly project to the HPC, while the deep layers (V/VI) receive the input from the HPC to provide telencephalic projections (4). For example, Reelin + cells in layer II of the EC project to the hippocampal DG, CA3, and CA2 (4-6). Pyramidal cells in layer III of the EC directly project to the hippocampal CA1(4, 7).…”

Section: Mainmentioning

confidence: 99%

“…Pyramidal cells in layer III of the EC directly project to the hippocampal CA1(4, 7). A subpopulation of Wolfram syndrome 1 (Wfs1) / CalbindinD-28K (CalB) + pyramidal cells in layer II of the EC project to the inhibitory neurons in the hippocampal CA1 area (4, 8, 9). On the other hand, in contrast to the superficial layers, the cell-type specific projection pattern for the deep layers of the EC are beginning to be studied.…”

Section: Mainmentioning

confidence: 99%

“…For example, Reelin + cells in layer II of the EC project to the hippocampal DG, CA3, and CA2 (4)(5)(6). Pyramidal cells in layer III of the EC directly project to the hippocampal CA1 (4,7). A subpopulation of Wolfram syndrome 1 (Wfs1) / CalbindinD-28K (CalB) + pyramidal cells in layer II of the EC project to the inhibitory neurons in the hippocampal CA1 area (4,8,9).…”

mentioning

confidence: 99%

“…On the other hand, in contrast to the superficial layers, the cell-type specific projection pattern for the deep layers of the EC are beginning to be studied. Layer V can be separated into two sublayers: Va and Vb (4,9,10). Vb neurons are known to function as a local projection to superficial layers in the EC (9,11,12), and Va neurons project to telencephalic structures (4,(9)(10)(11).…”

mentioning

confidence: 99%

“…Layer V can be separated into two sublayers: Va and Vb (4,9,10). Vb neurons are known to function as a local projection to superficial layers in the EC (9,11,12), and Va neurons project to telencephalic structures (4,(9)(10)(11). Previous studies raised the possibility that some neurons in the deep layers of the EC also may project back to the HPC (13,14).…”

mentioning

confidence: 99%

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Outer layer of Vb neurons in medial entorhinal cortex project to hippocampal dentate gyrus in mice

Yamamoto,

Yokose,

Ramesh

et al. 2023

Preprint

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Entorhinal cortical (EC)-hippocampal (HPC) circuits are crucial for learning and memory. Although it was traditionally believed that superficial layers (II/III) of the EC mainly project to the HPC and deep layers (V/VI) receive input from the HPC, recent studies have highlighted the significant projections from layers Va and VI of the EC into the HPC. However, it still remains unknown whether Vb neurons in the EC provide projections to the hippocampus. In this study, using a molecular marker for Vb and retrograde tracers, we identified that the outer layer of Vb in the medial EC (MEC) neurons directly project to both dorsal and ventral hippocampal DG, with a significant preference for the ventral DG. In contrast to the distribution of DG-projecting Vb cells, anterior thalamus-projecting Vb cells are distributed through the outer to the inner layer of Vb. Furthermore, dual tracer injections revealed that DG-projecting Vb cells and anterior thalamus-projecting Vb cells are distinct populations. These results suggest that the roles of MEC Vb neurons are not merely limited to the formation of EC-HPC loop circuits, but rather contribute to multiple neural processes for learning and memory.

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Section: Mainmentioning

confidence: 99%

Section: Mainmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Outer layer of Vb neurons in medial entorhinal cortex project to hippocampal dentate gyrus in mice

Yamamoto,

Yokose,

Ramesh

et al. 2023

Preprint

Self Cite

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Optogenetic activation of dopamine D1 receptors in island cells of medial entorhinal cortex inhibits temporal association learning

Yokose,

Yamamoto,

Ogawa

et al. 2023

Mol Brain

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A critical feature of episodic memory formation is to associate temporally segregated events as an episode, called temporal association learning. The medial entorhinal cortical-hippocampal (EC-HPC) networks is essential for temporal association learning. We have previously demonstrated that pyramidal cells in the medial EC (MEC) layer III project to the hippocampal CA1 pyramidal cells and are necessary for trace fear conditioning (TFC), which is an associative learning between tone and aversive shock with the temporal gap. On the other hand, Island cells in MECII, project to GABAergic neurons in hippocampal CA1, suppress the MECIII input into the CA1 pyramidal cells through the feed-forward inhibition, and inhibit TFC. However, it remains unknown about how Island cells activity is regulated during TFC. In this study, we report that dopamine D1 receptor is preferentially expressed in Island cells in the MEC. Optogenetic activation of dopamine D1 receptors in Island cells facilitate the Island cell activity and inhibited hippocampal CA1 pyramidal cell activity during TFC. The optogenetic activation caused the impairment of TFC memory recall without affecting contextual fear memory recall. These results suggest that dopamine D1 receptor in Island cells have a crucial role for the regulation of temporal association learning.

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Outer layer of Vb neurons in medial entorhinal cortex project to hippocampal dentate gyrus in mice

Yamamoto,

Yokose,

Ramesh

et al. 2024

Mol Brain

Self Cite

View full text Add to dashboard Cite

Entorhinal cortical (EC)-hippocampal (HPC) circuits are crucial for learning and memory. Although it was traditionally believed that superficial layers (II/III) of the EC mainly project to the HPC and deep layers (V/VI) receive input from the HPC, recent studies have highlighted the significant projections from layers Va and VI of the EC into the HPC. However, it still remains unknown whether Vb neurons in the EC provide projections to the hippocampus. In this study, using a molecular marker for Vb and retrograde tracers, we identified that the outer layer of Vb neurons in the medial EC (MEC) directly project to both dorsal and ventral hippocampal dentate gyrus (DG), with a significant preference for the ventral DG. In contrast to the distribution of DG-projecting Vb cells, anterior thalamus-projecting Vb cells are distributed through the outer to the inner layer of Vb. Furthermore, dual tracer injections revealed that DG-projecting Vb cells and anterior thalamus-projecting Vb cells are distinct populations. These results suggest that the roles of MEC Vb neurons are not merely limited to the formation of EC-HPC loop circuits, but rather contribute to multiple neural processes for learning and memory.

show abstract

Dissecting cell‐type‐specific pathways in medial entorhinal cortical‐hippocampal network for episodic memory

Cited by 4 publications

References 320 publications

Outer layer of Vb neurons in medial entorhinal cortex project to hippocampal dentate gyrus in mice

Outer layer of Vb neurons in medial entorhinal cortex project to hippocampal dentate gyrus in mice

Optogenetic activation of dopamine D1 receptors in island cells of medial entorhinal cortex inhibits temporal association learning

Outer layer of Vb neurons in medial entorhinal cortex project to hippocampal dentate gyrus in mice

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