Dissecting Aortic Aneurysm – Failure of Standard Noninvasive and Invasive Diagnostic Techniques

Abstract

The diagnosis of cardiac tamponade due to dissection of an ascending aortic aneurysm in a middle-aged woman was not confirmed by the usual noninvasive and invasive procedures. The decision for surgery was based on clinical grounds only, resulting in an unnecessary delay of surgical intervention. Although some of the current noninvasive techniques seem to be most useful in the investigation of these patients, the clinical findings remain the cornerstone of a correct diagnosis.

Role of Sphingolipids in the Pathobiology of Lung Inflammation

“…Such alteration of activities ensures a release of ceramide from sphingomyelin and then overcomes its clearance by degradation [ 91 ]. The same group, based on previously reported data [ 104 , 105 ], claimed that CFTR deficiency increases the pH of secretory vesicles produced by alveolar macrophages upon P. aeruginosa infection, correlating with a reduced production of ROS and reduced bactericidal activity and with ceramide intracellular accumulation and altered lipid raft formation on the plasma membrane [ 106 ].…”