Disruptive Mood Dysregulation Disorder

Tapia, Victoria; John, Rita Marie

doi:10.1016/j.nurpra.2018.07.007

Cited by 3 publications

(2 citation statements)

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“…Comorbidity is one of the obstacles which have been reported around the DMDD diagnosis [ 12 ]. The majority of patients with DMDD have at least one other comorbid psychiatric disorder, of which oppositional defiant disorder (ODD) or depressive disorders are most commonly reported [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic instruments for the assessment of disruptive mood dysregulation disorder: a systematic review of the literature

Mürner-Lavanchy

Kaess

Koenig

2021

Eur Child Adolesc Psychiatry

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Disruptive mood dysregulation disorder (DMDD) involves non-episodic irritability and frequent severe temper outbursts in children. Since the inclusion of the diagnosis in the DSM-5, there is no established gold-standard in the assessment of DMDD. In this systematic review of the literature, we provide a synopsis of existing diagnostic instruments for DMDD. Bibliographic databases were searched for any studies assessing DMDD. The systematic search of the literature yielded K = 1167 hits, of which n = 110 studies were included. The most frequently used measure was the Kiddie Schedule for Affective Disorders and Schizophrenia DMDD module (25%). Other studies derived diagnostic criteria from interviews not specifically designed to measure DMDD (47%), chart review (7%), clinical diagnosis without any specific instrument (6%) or did not provide information about the assessment (9%). Three structured interviews designed to diagnose DMDD were used in six studies (6%). Interrater reliability was reported in 36% of studies (ranging from κ = 0.6–1) while other psychometric properties were rarely reported. This systematic review points to a variety of existing diagnostic measures for DMDD with good reliability. Consistent reporting of psychometric properties of recently developed DMDD interviews, as well as their further refinement, may help to ascertain the validity of the diagnosis.

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Section: Introductionmentioning

confidence: 99%

“…Hence, many existing measures provide questions which assess symptoms relevant to DMDD (e.g. irritability is measured but considered a nonspecific indicator and is related to several other psychiatric disorders) [ 12 ]. Moreover, structured interviews or questionnaires specifically developed to diagnose DMDD are still in their infancy.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic instruments for the assessment of disruptive mood dysregulation disorder: a systematic review of the literature

Mürner-Lavanchy

Kaess

Koenig

2021

Eur Child Adolesc Psychiatry

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Systematic Review and Meta-Analysis: Pharmacological and Nonpharmacological Interventions for Disruptive Mood Dysregulation Disorder

Zhang,

2024

Journal of Child and Adolescent Psychopharmacology

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BackgroundDisruptive mood dysregulation disorder (DMDD) is a relatively new diagnostic approach that focuses on describing severe, non-episodic irritability and recurrent outbursts of emotional instability in adolescents. MethodsThis meta-analysis examined the e cacy of the available pharmacological and nonpharmacological interventions for DMDD. Literature searches were conducted in July 2023. To determine relevant papers, 330 abstracts were reviewed, and 39 articles were identi ed for full review. A random-effects model was used for the meta-analysis, and a subgroup analysis was used to assess the effects of study design and intervention type. Eleven studies were included (six pharmacological and ve nonpharmacological). ResultsDespite high heterogeneity in effects (I²=85%), we showed statistically signi cant improvement to irritability symptoms following intervention (standardized mean difference = 0.78, 95% con dence interval = 0.21-1.36, Z = 2.68, P 0.05). The subgroup analysis showed that, compared with randomized controlled trials (RCTs), participants in open trials showed signi cant improvement in irritability. Additionally, drug intervention signi cantly improved irritability compared to non-drug interventions. Atomoxetine, optimized stimulants, or stimulants combined with other drugs and behavioral therapy effectively improved irritability. However, large-sample RCTs are needed to explore DMDD treatment without potential in uencing factors. ConclusionIn conclusion, treatment strategies for persistent non-periodic irritability in youths with DMDD are diverse, and because of DMDD symptoms and its intersection with other diseases, it is necessary to combine multiple treatment strategies.

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Systematic review and meta-analysis: Pharmacological and nonpharmacological interventions for disruptive mood dysregulation disorder

zhang,

Zhang

2024

Preprint

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Background Disruptive mood dysregulation disorder (DMDD) is a relatively new diagnostic approach that focuses on describing severe, non-episodic irritability and recurrent outbursts of emotional instability in adolescents. Methods This meta-analysis examined the efficacy of the available pharmacological and nonpharmacological interventions for DMDD. Literature searches were conducted in July 2023. To determine relevant papers, 330 abstracts were reviewed, and 39 articles were identified for full review. A random-effects model was used for the meta-analysis, and a subgroup analysis was used to assess the effects of study design and intervention type. Eleven studies were included (six pharmacological and five nonpharmacological). Results Despite high heterogeneity in effects (I²=85%), we showed statistically significant improvement to irritability symptoms following intervention (standardized mean difference = 0.78, 95% confidence interval = 0.21–1.36, Z = 2.68, P༜0.05). The subgroup analysis showed that, compared with randomized controlled trials (RCTs), participants in open trials showed significant improvement in irritability. Additionally, drug intervention significantly improved irritability compared to non-drug interventions. Atomoxetine, optimized stimulants, or stimulants combined with other drugs and behavioral therapy effectively improved irritability. However, large-sample RCTs are needed to explore DMDD treatment without potential influencing factors. Conclusion In conclusion, treatment strategies for persistent non-periodic irritability in youths with DMDD are diverse, and because of DMDD symptoms and its intersection with other diseases, it is necessary to combine multiple treatment strategies.

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Disruptive Mood Dysregulation Disorder

Cited by 3 publications

References 37 publications

Diagnostic instruments for the assessment of disruptive mood dysregulation disorder: a systematic review of the literature

Diagnostic instruments for the assessment of disruptive mood dysregulation disorder: a systematic review of the literature

Systematic Review and Meta-Analysis: Pharmacological and Nonpharmacological Interventions for Disruptive Mood Dysregulation Disorder

Systematic review and meta-analysis: Pharmacological and nonpharmacological interventions for disruptive mood dysregulation disorder

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