Disruptive effects of plasticizers bisphenol A, F, and S on steroidogenesis of adrenocortical cells
Benedikt Pötzl,
Lydia Kürzinger,
Sabine Kendl
et al.
Abstract:IntroductionEndocrine disrupting chemicals (EDCs) are known to interfere with endocrine homeostasis. Their impact on the adrenal cortex and steroidogenesis has not yet been sufficiently elucidated. This applies in particular to the ubiquitously available bisphenols A (BPA), F (BPF), and S (BPS).MethodsNCI-H295R adrenocortical cells were exposed to different concentrations (1nM-1mM) of BPA, BPF, BPS, and an equimolar mixture of them (BPmix). After 72 hours, 15 endogenous steroids were measured using LC-MS/MS. R… Show more
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