Disruptions of sensorimotor gating, cytokines, glycemia, monoamines, and genes in both sexes of rats reared in social isolation can be ameliorated by oral chronic quetiapine administration

Ko, Chih‐Yuan; Liu, Yia-Ping

doi:10.1016/j.bbi.2015.08.003

Cited by 32 publications

(25 citation statements)

References 76 publications

(132 reference statements)

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“…In addition, stress-induced activation of the HPA axis and alterations in glucocorticoid functioning can affect the brain-adipose axis, resulting in increased visceral fat storage (17,18,155,167). Indeed, individual housing has been found to disrupt plasma glycaemic and lipid profiles (80,81,89,137), adipocyte morphology and hepatic/adipocyte gene expression profiles involved in lipid metabolism (40,42,88), even in the absence of concurrent changes in body weight. In turn, increased fatty acid overflow from the visceral depot towards the liver stimulates the sympatho-adrenal system and the HPA axis, (168) which can ignite a vicious circle, worsening metabolic syndrome characteristics (169).…”

Section: Proposed Mechanisms By Which Individual Housing Affects Enermentioning

confidence: 99%

Home alone: a systematic review and meta‐analysis on the effects of individual housing on body weight, food intake and visceral fat mass in rodents

Schipper

Harvey²,

Beek

et al. 2018

Obesity Reviews

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Rats and mice are widely used to study environmental effects on psychological and metabolic health. Study designs differ widely and are often characterized by varying (social) housing conditions. In itself, housing has a profound influence on physiology and behaviour of rodents, affecting energy balance and sustainable metabolic health. However, evidence for potential long-term consequences of individual versus social housing on body weight and metabolic phenotype is inconsistent. We conducted a systematic literature review and meta-analyses assessing effects of individual versus social housing of rats and mice, living under well-accepted laboratory conditions, on measures of metabolic health, including body weight, food intake and visceral adipose tissue mass. Seventy-one studies were included in this review; 59 were included in the meta-analysis. Whilst housing did not affect body weight, both food intake and visceral adipose tissue mass were significantly higher in individually compared with socially housed animals. A combination of emotional stress and lack of social thermoregulation likely contributed to these effects. Increased awareness of consequences and improved specifications of housing conditions are necessary to accurately evaluate efficacy of drugs, diets or other interventions on metabolic and other health outcomes because housing conditions are rarely considered as possible moderators of reported outcomes.

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Section: Proposed Mechanisms By Which Individual Housing Affects Enermentioning

confidence: 99%

Home alone: a systematic review and meta‐analysis on the effects of individual housing on body weight, food intake and visceral fat mass in rodents

Schipper

Harvey²,

Beek

et al. 2018

Obesity Reviews

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“…Inflammatory mediators can be produced by peripheral and central cells. Peripheral inflammatory mediators may invade the CNS by crossing the blood– brain barrier, affecting behaviors and causing metabolic problems and psychiatric disorders [24]. Here, our data suggest that the gut microbiota impact the brain in OSAHS patients by modulating inflammatory responses.…”

Section: Discussionmentioning

confidence: 65%

Association ofPrevotellaenterotype with polysomnographic data in obstructive sleep apnea/hypopnea syndrome patients

Fan

et al. 2018

Preprint

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27Intermittent hypoxia and sleep fragmentation are critical pathophysiological 28 processes involved in obstructive sleep apnea/hypopnea syndrome (OSAHS). These 29 manifestation independently affect similar brain regions and contribute to 30 OSAHS-related comorbidities that are known to be related to the host gut alteration 31 microbiota. We hypothesized that microbiota disruption influences the 32 pathophysiological processes of OSAHS through a microbiota-gut-brain axis. Thus, 33we aim to survey enterotypes and polysomnographic data of OSAHS patients. 34Subjects were diagnosed by polysomnography, from whom fecal samples were 48. CC-BY-ND 4.0 International license It is made available under a (which was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.The copyright holder for this preprint . http://dx.doi.org/10.1101/394064 doi: bioRxiv preprint first posted online Aug. 17, 2018; obstructive sleep apnea/hypopnea syndrome

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“…Inflammatory mediators can be produced by peripheral and central cells. Peripheral inflammatory mediators may invade the CNS by crossing the blood–brain barrier, affecting behaviors and causing metabolic problems and psychiatric disorders (Ko & Liu, ). Here, our data suggest that the gut microbiota might impact the brain in OSAHS patients by modulating inflammatory responses.…”

Section: Discussionmentioning

confidence: 99%

“…Monosaccharide intake induces inflammation in epithelial cells and contributes to hypertension (Orlando et al, ), linking to LPS production, which can stimulate systemic inflammatory cascades (Moreno‐Indias et al, ). Inflammation mediates the pathogenesis of many physiological dysfunctions, such as metabolic syndrome and mental dysfunction (Ko & Liu, ), and thus might ultimately result in OSAHS‐related metabolic comorbidities. Although Ruminococcus is associated with resistant starch, host health benefits from short chain fatty acids that have been demonstrated to regulate immune inflammatory responses (Macfarlane & Macfarlane, ).…”

Section: Discussionmentioning

confidence: 99%

Disruption of sleep architecture in Prevotella enterotype of patients with obstructive sleep apnea‐hypopnea syndrome

Fan

et al. 2019

Brain and Behavior

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Introduction Intermittent hypoxia and sleep fragmentation are critical pathophysiological processes involved in obstructive sleep apnea‐hypopnea syndrome (OSAHS). Those manifestations independently affect similar brain regions and contribute to OSAHS‐related comorbidities that are known to be related to the host gut alteration microbiota. We hypothesized that gut microbiota disruption may cross talk the brain function via the microbiota–gut–brain axis. Thus, we aim to survey enterotypes and polysomnographic data of patients with OSAHS. Methods Subjects were diagnosed by polysomnography, from whom fecal samples were obtained and analyzed for the microbiome composition by variable regions 3–4 of 16S rRNA pyrosequencing and bioinformatic analyses. We examined the fasting levels of interleukin‐6 and tumor necrosis factor‐alpha of all subjects. Results Three enterotypes Bacteroides , Ruminococcus , and Prevotella were identified in patients with OSAHS. Arousal‐related parameters or sleep stages are significantly disrupted in apnea‐hypopnea index (AHI) ≥15 patients with Prevotella enterotype; further analysis this enterotype subjects, obstructive, central, and mixed apnea indices, and mean heart rate are also significantly elevated in AHI ≥15 patients. However, blood cytokines levels of all subjects were not significantly different. Conclusions This study indicates the possibility of pathophysiological interplay between enterotypes and sleeps structure disruption in sleep apnea through a microbiota–gut–brain axis and offers some new insight toward the pathogenesis of OSAHS.

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Disruptions of sensorimotor gating, cytokines, glycemia, monoamines, and genes in both sexes of rats reared in social isolation can be ameliorated by oral chronic quetiapine administration

Cited by 32 publications

References 76 publications

Home alone: a systematic review and meta‐analysis on the effects of individual housing on body weight, food intake and visceral fat mass in rodents

Home alone: a systematic review and meta‐analysis on the effects of individual housing on body weight, food intake and visceral fat mass in rodents

Association ofPrevotellaenterotype with polysomnographic data in obstructive sleep apnea/hypopnea syndrome patients

Disruption of sleep architecture in Prevotella enterotype of patients with obstructive sleep apnea‐hypopnea syndrome

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