Disruptions in the reproductive system of female rats after prenatal lipopolysaccharide-induced immunological stress: role of sex steroids

Ignatiuk, Vasilina; Izvol’skaya, M. S.; Sharova, Viktoria; Voronova, S. N.; Захарова, Л. А.

doi:10.1080/10253890.2018.1508440

Cited by 13 publications

(9 citation statements)

References 43 publications

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“…In experimental models, MIA via bacterial LPS results in altered levels of various cytokines in both mother and fetus [13]. Increased levels of cytokines induced via inflammation during the early stages of pregnancy can be one of the risk factors causing developmental disorders of the immune and neuroendocrine systems, including the hypothalamic-pituitary-gonadal axis (HPG axis), in fetuses [5,27]. The consequences of these disorders can develop throughout postnatal ontogenesis.…”

Section: Discussionmentioning

confidence: 99%

Disruption of Intranasal GnRH Neuronal Migration Route into the Brain Induced by Proinflammatory Cytokine IL-6: Ex Vivo and In Vivo Rodent Models

Sharova,

Ignatiuk,

Izvolskaia

et al. 2023

IJMS

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Maternal immune activation results in altered levels of cytokines in the maternal–fetal system, which has a negative impact on fetal development, including the gonadotropin-releasing hormone (GnRH) system, which is crucial for the reproduction. Suppression of GnRH–neuron migration may be associated with cytokine imbalances, and primarily with proinflammatory cytokine interleukin (IL)-6. This study aimed to determine the effects of IL-6 and monoclonal antibody to IL-6 or IL-6R or polyclonal IgG on the formation of migration route of GnRH–neurons in ex vivo and in vivo rodent models on day 11.5 of embryonic development. The increased level of IL-6 in mouse nasal explants suppressed peripherin-positive fiber outgrowth, while this led to an increase in the number of GnRH–neurons in the nose and olfactory bulbs and a decrease in their number in the fetal brain. This effect is likely to be realized via IL-6 receptors along the olfactory nerves. The suppressive effect of IL-6 was diminished by monoclonal antibodies to IL-6 or its receptors and by IgG.

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Section: Discussionmentioning

confidence: 99%

Disruption of Intranasal GnRH Neuronal Migration Route into the Brain Induced by Proinflammatory Cytokine IL-6: Ex Vivo and In Vivo Rodent Models

Sharova,

Ignatiuk,

Izvolskaia

et al. 2023

IJMS

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“…As we previously mentioned, regarding reciprocal relationships between the HPG axis and the immune system, a mutual alteration is generated in the functioning of both systems [ 39 , 40 ]. Systemic infectious processes cause the synthesis of proinflammatory cytokines in the hypothalamic medial preoptic area, where cell bodies of GnRH neurons are located [ 41 ].…”

Section: Immune Challenge On the Hypothalamic–pituitary–gonadal Axismentioning

confidence: 99%

Endocannabinoid System in the Neuroendocrine Response to Lipopolysaccharide-induced Immune Challenge

Laurentiis

Correa

Fernández‐Solari

2022

Journal of the Endocrine Society

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The endocannabinoid system plays a key role in the intersection of the nervous, endocrine, and immune system, regulating not only their functions but also how they interplay with each other. Endogenous ligands, named endocannabinoids, are produced “on demand” to finely regulate the synthesis and secretion of hormones and neurotransmitters, as well as to regulate the production of cytokines and other proinflammatory mediators. It is well known that immune challenges, such as exposure to lipopolysaccharide (LPS), the main component of the Gram-negative bacteria cell wall, disrupts not only the hypothalamic-pituitary-adrenal axis but also affects other endocrine systems such as the hypothalamic-pituitary-gonadal axis and the release of oxytocin from the neurohypophysis. Here we explore which actors and molecular mechanisms are involved in these processes.

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“…Infections associated with immunological events in early/middle fetal life (8-10 days of gestation in rats and mice) might have a stronger neurodevelopmental impact than late-pregnancy infections (Kirsten et al 2011). Previously, a decrease in body weight in the female and male offspring of rats after exposure to LPS at a dose of 50 μg/kg in early pregnancy was shown (Ignatiuk et al 2019, Izvolskaia et al 2019. According to the data, LPS at a dose of 100 μg/kg caused an increase in body weight in the male offspring of mice (Fig.…”

Section: Allmentioning

confidence: 99%

“…Since the consequences of negative effects on the fetus cannot always be traced, the conducted therapy often does not allow eliminating the identified fertility disorders. We have demonstrated the possibility of correcting disorders in the functional activity of the reproductive systems of male and female rats induced by prenatal exposure to LPS, by using antagonists of sex steroids in the early postnatal period (Ignatiuk et al 2019, Izvolskaia et al 2019,2020. Attempts are currently being made to neutralize bacterial infections by the i.v.…”

Section: Introductionmentioning

confidence: 99%

IgG modulation in male mice with reproductive failure after prenatal inflammation

et al. 2021

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Sexual performance in adult male rats is highly sensitive to prenatal stress which can affect the functionality of the reproductive system and various brain structures involved in modulating sexual behavior. The immunomodulatory effect of mouse IgG on reproductive maturity in male offspring after LPS exposure in vivo and in vitro was studied. Prenatal IgG injection (20 µg / mouse) had a positive impact on the puberty of male mice whose mothers were exposed to LPS (100 µg / kg) on the 12th day of pregnancy. The number of Sertoli cells were increased, whereas the body weight and the number of symplastic spermatids were decreased in offspring as compared to LPS-treated animals. Besides, IgG had a positive effect on altered hormone levels: reduced estradiol level on the 5th and 14th postnatal days and increased testosterone level on the 30th postnatal day in blood that led to an increased number of mounting attempts in sexually mature males. The cAMP-dependent pathway may be involved in the regulation of the LPS-induced inflammation. IgG reduced the increased level of cAMP in mouse peritoneal macrophages activated by LPS in vitro. IgG is able to modulate inflammation processes, but its exposure time is important.

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Disruptions in the reproductive system of female rats after prenatal lipopolysaccharide-induced immunological stress: role of sex steroids

Cited by 13 publications

References 43 publications

Disruption of Intranasal GnRH Neuronal Migration Route into the Brain Induced by Proinflammatory Cytokine IL-6: Ex Vivo and In Vivo Rodent Models

Disruption of Intranasal GnRH Neuronal Migration Route into the Brain Induced by Proinflammatory Cytokine IL-6: Ex Vivo and In Vivo Rodent Models

Endocannabinoid System in the Neuroendocrine Response to Lipopolysaccharide-induced Immune Challenge

IgG modulation in male mice with reproductive failure after prenatal inflammation

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