Disruptions in oral and nasal microbiota in biomass and tobacco smoke associated chronic obstructive pulmonary disease

Aggarwal, Dhiraj; Dhotre, Dhiraj; Kumbhare, Shreyas V.; Gaike, Akshay H.; Brashier, Bill; Shouche, Yogesh S.; Juvekar, Sanjay; Salvi, Sundeep

doi:10.1007/s00203-020-02155-9

Cited by 13 publications

(16 citation statements)

References 52 publications

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“…The nasal microbiota of COPD smokers was characterized by an increase in the abundance of pathogens, such as Actinomyces , Actinobacillus , Megasphaera , and Selenomonas spp. [ 44 ]. Other authors report an increased prevalence of Haemophilus spp.…”

Section: Resultsmentioning

confidence: 99%

The Impact of Smoking on Microbiota: A Narrative Review

et al. 2023

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Cigarette smoke is a classic risk factor for many diseases. The microbiota has been recently indicated as a new, major player in human health. Its deregulation—dysbiosis—is considered a new risk factor for several illnesses. Some studies highlight a cross-interaction between these two risk factors—smoke and dysbiosis—that may explain the pathogenesis of some diseases. We searched the keywords “smoking OR smoke AND microbiota” in the title of articles on PubMed®, UptoDate®, and Cochrane®. We included articles published in English over the last 25 years. We collected approximately 70 articles, grouped into four topics: oral cavity, airways, gut, and other organs. Smoke may impair microbiota homeostasis through the same harmful mechanisms exerted on the host cells. Surprisingly, dysbiosis and its consequences affect not only those organs that are in direct contact with the smoke, such as the oral cavity or the airways, but also involve distant organs, such as the gut, heart, vessels, and genitourinary tract. These observations yield a deeper insight into the mechanisms implicated in the pathogenesis of smoke-related diseases, suggesting a role of dysbiosis. We speculate that modulation of the microbiota may help prevent and treat some of these illnesses.

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Section: Resultsmentioning

confidence: 99%

The Impact of Smoking on Microbiota: A Narrative Review

et al. 2023

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“…In our data, Acidaminococcus was better associated with the group of patients with Severe Obesity (OB-SO-G) (Supplementary Table 4). Therefore, it was not surprising that others have found such an increase in patients with type 2 diabetes (T2D) 24 .Sutterella genus was already described to correlate positively with obesity in obese Chinese children 25 , but others found the opposite in adults 26 . In line with this data, Sutterellawadsworthensis was reported to be positively associated with insulin resistance 27 .…”

Section: Discussionmentioning

confidence: 99%

Gut-microbiota in Obese Children and Adolescents: Inferred Functional Analysis and Machine-learning Algorithms to Classify Microorganisms

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Bonaretti

Valle

et al. 2023

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The fecal microbiome of 55 obese children and adolescents (BMI-SDS 3.2+/-0.7) and of 25 normal-weight subjects, matched both for age and sex (BMI-SDS -0.3+/-1.1). Streptococcus, Acidaminococcus, Sutterella, Prevotella, Sutterellawadsworthensis, Streptococcus thermophilus, and Prevotellacopri positively correlated with obesity. The inferred pathways strongly associated with obesity concern the biosynthesis pathways of tyrosine, phenylalanine, tryptophan and methionine pathways. Furthermore, polyamine biosynthesis virulence factors and pro-inflammatory lipopolysaccharide biosynthesis pathway showed higher abundances in obese samples, while the butanediol biosynthesis showed low abundance in obese subjects. Different taxa strongly linked with obesity have been related to an increased risk of multiple diseases involving metabolic pathways related to inflammation (polyamine and lipopolysaccharide biosynthesis). Cholesterol, LDL, and CRP positively correlated with specific clusters of microbial in obese patients. The Firmicutes/Bacteroidetes-ratio was lower in obese samples than in controls and differently from the literature we state that this ratio could not be a biomarker for obesity.

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“…In COPD, the microbiota diversity in the samples depends on the type of treatment received, disease severity, and inflammation. A study aimed at comparing the microbial diversity from nasal and oral cavities of healthy patients, including the risk factors of tobacco smoke-associated COPD (TSCOPD) and biomass smoke-associated COPD (BMSCOPD), showed significant differences in the microbiota in healthy vs. COPD and/or, TSCOPD vs. BMSCOPD subjects [ 67 ]. In particular, Actinomyces , Actinobacillus , Megasphaera , Selenomonas , and Corynebacterium were significantly higher in COPD subjects.…”

Section: Lung Microbial Dysbiosis and Copdmentioning

confidence: 99%

“…Acinetobacter was higher in the oral samples of TSCOPD subjects, while Gallibacterium and Methanosaeta were higher in the nasal samples of BMSCOPD subjects. The presence of a specific microbial community of bacteria in BMSCOPD suggested a difference in the pathophysiology of BMSCOPD, compared with TSCOPD, and also explained the clinical phenotypic differences between these groups ( Table 1 ) [ 67 ]. When comparing the microbiota diversity of COPD and other chronic lung diseases characterised by a rapid decline in lung function, such as idiopathic pulmonary fibrosis (IPF), it has been reported that the most abundant genera were Streptococcus sp., Rothia , Veillonella , and Prevotella [ 68 ].…”

Section: Lung Microbial Dysbiosis and Copdmentioning

confidence: 99%

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Impact of Lung Microbiota on COPD

et al. 2022

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There is a fine balance in maintaining healthy microbiota composition, and its alterations due to genetic, lifestyle, and environmental factors can lead to the onset of respiratory dysfunctions such as chronic obstructive pulmonary disease (COPD). The relationship between lung microbiota and COPD is currently under study. Little is known about the role of the microbiota in patients with stable or exacerbated COPD. Inflammation in COPD disorders appears to be characterised by dysbiosis, reduced lung activity, and an imbalance between the innate and adaptive immune systems. Lung microbiota intervention could ameliorate these disorders. The microbiota's anti-inflammatory action could be decisive in the onset of pathologies. In this review, we highlight the feedback loop between microbiota dysfunction, immune response, inflammation, and lung damage in relation to COPD status in order to encourage the development of innovative therapeutic goals for the prevention and management of this disease.

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Disruptions in oral and nasal microbiota in biomass and tobacco smoke associated chronic obstructive pulmonary disease

Cited by 13 publications

References 52 publications

The Impact of Smoking on Microbiota: A Narrative Review

The Impact of Smoking on Microbiota: A Narrative Review

Gut-microbiota in Obese Children and Adolescents: Inferred Functional Analysis and Machine-learning Algorithms to Classify Microorganisms

Impact of Lung Microbiota on COPD

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