Disruption of Visuospatial and Somatosensory Functional Connectivity in Anorexia Nervosa

Partially restored resting-state functional connectivity in women recovered from anorexia nervosa

“…Cowdrey and colleagues 22 reported increased rsFC in the DMN but no differences in the FPN, the visual or somatosensory networks. In contrast, reduced rsFC in the visual network was reported by Favaro and colleagues, 23 while McFadden and colleagues 24 showed reduced rsFC strength in the salience network and sensorimotor network (the latter data were obtained during a task that may impact RSNs 25 ). Using a seedbased approach, Favaro and colleagues 26 reported that the observed alterations in rsFC of the striatal network in acutely ill patients vanished with recovery.…”

Abnormal functional global and local brain connectivity in female patients with anorexia nervosa

“…Favaro and colleagues 15,55 reported anorexia nervosa-related decreases in temporal coherence in a ventral visual network and decreased RSFC of the putamen with the cingulate gy rus, amygdalae and precentral gyrus, using ICA and seed based analysis, respectively. Using the latter approach, Kim Mid-insula_L_61 Postinsula_L_76…”

“…The existing studies, which are often limited by small sample sizes, typically used independent component analysis (ICA) or seed based connectivity analysis 13 to probe specific known networks, such as the default mode, somatosensory or salience networks. [14][15][16] See Appendix 1, Table S8 (available at jpn.ca), for an overview of all known RSFC studies in pa tients with anorexia nervosa.…”

Altered intrinsic functional brain architecture in female patients with bulimia nervosa

“…The sensorimotor cortex provides an obligatory portal for the entry of sensory information into the cortical circuitry and is important for awareness of body sensations, size and spatial positions, 31 whereas the occipital cortex mediates visual perception of body shape and/or size. 43 The sensorimotor and occipital regions are thus potentially relevant to the behavioural manifestation of distorted body image (i.e., overestimation of body size, body dissatisfaction and body weight control), which has an important role in the onset and maintenance of eating disorders 44 and seems to be more pronounced in patients with bulimia nervosa than in those who have anorexia nervosa. 45 The relevance of the sensorimotor and occipital regions to distorted body image has been emphasized in several previous studies.…”