Disruption of the structural and functional connectivity of the frontoparietal network underlies symptomatic anxiety in late-life depression

Li, Hui; Lin, Xiao; Liu, Lin; Su, Shihao; Zhu, Xianyang; Zheng, Yong-Bo; Huang, Weizhen; Que, Jian-Yu; Shi, Le; Bao, Yanping; Lü, Lin; Deng, Jiahui; Sun, Xinyu

doi:10.1016/j.nicl.2020.102398

Cited by 22 publications

(16 citation statements)

References 55 publications

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“…Furthermore, higher plasma homocysteine levels were associated with poorer cognition in patients with LLD ( Zhou et al, 2020 ). In the current study, we discovered lower FA values in the bilateral inferior longitudinal fasciculus in LLD patients, which is consistent with the majority of prior findings on FA values in patients with LLD ( Alves et al, 2012 ; Mettenburg et al, 2012 ; Guo et al, 2014 ; Li et al, 2014 , 2020 ; Wen et al, 2014 ; Emsell et al, 2017 ), confirming the LLD disconnection theory. Furthermore, we recognized a reverse relationship between plasma Hcy concentrations and FA values in the forceps minor in patients with LLD, suggesting that Hcy level is related to the WM structure.…”

Section: Discussionsupporting

confidence: 92%

Elevated homocysteine levels, white matter abnormalities and cognitive impairment in patients with late-life depression

Zhou

Zhong

Chen

et al. 2022

Front. Aging Neurosci.

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BackgroundCognitive impairment in late−life depression (LLD) is considered to be caused by neurodegenerative changes. Elevated homocysteine (Hcy) levels may be linked to cognitive abnormalities associated with LLD. The important role of white matter (WM) damage in cognitive impairment and pathogenesis in patients with LLD has been widely reported. However, no research has explored the interrelationships of these features in patients with LLD.ObjectiveThe goal of the study was to examine the interrelationship between Hcy levels, cognition, and variations in WM microstructure detected by diffusion tensor imaging (DTI) in patients with LLD.MethodsWe recruited 89 healthy controls (HCs) and 113 patients with LLD; then, we measured the plasma Hcy levels of participants in both groups. All individuals performed a battery of neuropsychological tests to measure cognitive ability. Seventy-four patients with LLD and 68 HCs experienced a DTI magnetic resonance imaging (MRI) scan.ResultsPatients with LLD showed significantly lower fractional anisotropy (FA) values in the bilateral inferior longitudinal fasciculus than those of healthy participants. Only in LLD patients was Hcy concentration inversely associated to FA values in the forceps minor. Finally, multiple regression analyses showed that an interaction between Hcy levels and FA values in the right cingulum of the cingulate cortex and right inferior longitudinal fasciculus were independent contributors to the executive function of patients with LLD.ConclusionOur results highlight the complex interplay between elevated homocysteine levels and WM abnormalities in the pathophysiology of LLD-related cognitive impairment, consistent with the neurodegeneration hypothesis.

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Section: Discussionsupporting

confidence: 92%

Elevated homocysteine levels, white matter abnormalities and cognitive impairment in patients with late-life depression

Zhou

Zhong

Chen

et al. 2022

Front. Aging Neurosci.

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“…Similarly, altered intrinsic connectivity between or within networks was observed in resting state. The RSFC within the FPN was inversely correlated with the severity of anxiety in line with the resting-state studies that indicate that the RSFC of the FPN was negatively correlated with the anxiety level ( 73 , 74 ), indicating that dysfunction in the FPN may be associated with anxiety in informal PD caregivers. Furthermore, the RSFC between the DMN and the FPN and within FPN was positively correlated with cognitive function, including execution, attention/working memory, memory, and visuospatial function.…”

Section: Discussionsupporting

confidence: 86%

The impact of anxiety on the cognitive function of informal Parkinson’s disease caregiver: Evidence from task-based and resting-state fNIRS

Wang

Liu

et al. 2022

Front. Psychiatry

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Informal Parkinson’s disease (PD) caregivers are considered to experience high levels of caregiver burden, negatively affecting the health of caregivers. However, few studies explored the relationship between anxiety in caregiver burden and cognitive function in informal PD caregivers. Although, no study has even investigated the neural mechanisms underlying this connection. This study aimed to conduct comprehensive cognitive and clinical assessments and evaluate brain activity from task-based state and resting-state using functional near-infrared spectroscopy (fNIRS). A total of ten informal PD caregivers and 15 matched, healthy, non-caregivers were recruited. Comprehensive cognitive and clinical assessments were conducted to evaluate five cognitive domains and mental states. Neural activity induced by verbal fluency task (VFT) and brain connectivity during resting state were monitored, and their correlations with the neuropsychological and clinical tests were explored. Our results showed that compared to non-caregiver, an informal PD caregiver exhibited no difference in most cognitive domains of function but performed better in attentional function, along with higher levels of anxiety. Decreased activation over prefrontal regions during VFT and hypo-connectivity within the frontoparietal network (FPN) and between default mode network (DMN) and FPN in the resting state were confirmed in this study as a result of the negative effects of anxiety on the brain. Furthermore, Spearman’s correlation found that neural activity in FPN during task-based state and resting state was negatively correlated with the severity of anxiety. These findings indicate that despite normal or even better cognitive function, informal PD caregivers have impaired brain function, and this deficit in neural activity was related to anxiety.

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“…Illness duration also correlated with a volume reduction of the hippocampus, putamen, insula, and mPFC ( 20 – 22 ). Resting-state functional magnetic resonance imaging (fMRI) studies reported a reduction of connectivity between the amygdala and dorsal frontal regions in LLD patients ( 23 ), with disruptions of the fronto-parietal network ( 24 ). Brain connectivity between the fronto-parietal network and regions that are involved in sensory information processing were restored after MBCT in patients with major depression ( 25 ).…”

Section: Introductionmentioning

confidence: 99%

Mindfulness-Based Cognitive Therapy Regulates Brain Connectivity in Patients With Late-Life Depression

Yan

Wang

et al. 2022

Front. Psychiatry

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Late-life depression (LLD) is an important public health problem among the aging population. Recent studies found that mindfulness-based cognitive therapy (MBCT) can effectively alleviate depressive symptoms in major depressive disorder. The present study explored the clinical effect and potential neuroimaging mechanism of MBCT in the treatment of LLD. We enrolled 60 participants with LLD in an 8-week, randomized, controlled trial (ChiCTR1800017725). Patients were randomized to the treatment-as-usual (TAU) group or a MBCT+TAU group. The Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA) were used to evaluate symptoms. Magnetic resonance imaging (MRI) was used to measure changes in resting-state functional connectivity and structural connectivity. We also measured the relationship between changes in brain connectivity and improvements in clinical symptoms. HAMD total scores in the MBCT+TAU group were significantly lower than in the TAU group after 8 weeks of treatment (p < 0.001) and at the end of the 3-month follow-up (p < 0.001). The increase in functional connections between the amygdala and middle frontal gyrus (MFG) correlated with decreases in HAMA and HAMD scores in the MBCT+TAU group. Diffusion tensor imaging analyses showed that fractional anisotropy of the MFG-amygdala significantly increased in the MBCT+TAU group after 8-week treatment compared with the TAU group. Our study suggested that MBCT improves depression and anxiety symptoms that are associated with LLD. MBCT strengthened functional and structural connections between the amygdala and MFG, and this increase in communication correlated with improvements in clinical symptoms.Randomized Controlled Trial; Follow-Up Study; fMRI; Brain Connectivity

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Disruption of the structural and functional connectivity of the frontoparietal network underlies symptomatic anxiety in late-life depression

Cited by 22 publications

References 55 publications

Elevated homocysteine levels, white matter abnormalities and cognitive impairment in patients with late-life depression

Elevated homocysteine levels, white matter abnormalities and cognitive impairment in patients with late-life depression

The impact of anxiety on the cognitive function of informal Parkinson’s disease caregiver: Evidence from task-based and resting-state fNIRS

Mindfulness-Based Cognitive Therapy Regulates Brain Connectivity in Patients With Late-Life Depression

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