Disruption of the jejunal migrating motor complex by gastric distension and feeding in the dog.

Bull, J S; Grundy, David; Scratcherd, T

doi:10.1113/jphysiol.1987.sp016876

Cited by 8 publications

(4 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Infusion of hyperosmolar solutions and intake of meals are known occasionally to initiate a burst of activity at the slow wave frequency. '*-'' Bull et al observed a burst of regular contractions in 18 The present study shows that the motor reponse to caloric meals depends on phase of MMC at food intake, suggesting that this enteric rhythm continues to cycle during the postprandial period, even if the contractile pattern of MMC is mainly concealed by food-induced irregular contractile activity. This modified concept of postprandial motility allows previous and recent observations to be e~p l a i n e d .…”

Section: Discussionsupporting

confidence: 59%

The migrating motor complex modulates intestinal motility response and rate of gastric emptying of caloric meals

Medhus

Sandstad

Bredesen

et al. 1995

Neurogastroenterology Motil

View full text Add to dashboard Cite

The present study elucidates whether the phase of the migrating motor complex (MMC) present at the moment of food intake modulates postprandial motor response and rate of gastric emptying of caloric meals. Eight healthy male volunteers with a mean age of 26 years were examined twice. During water-perfused gastroduodenal manometry, a liquid meal with paracetamol added as a marker was orally administered during phase I and late phase II. Paracetamol appeared in serum 14.1 +/- 3.8 min and 9.1 +/- 4.0 (mean +/- SD) min, respectively, after intake of the meal (P < 0.02). The area under the curve of s-paracetamol until 25 min after intake was 232 +/- 169 mumol l-1 min and 362 +/- 130 (P < 0.05), respectively. When taken during late phase II, a phase III-like activity occurred within 2.1 +/- 1.3 min in the duodenum, and was succeeded by quiescence. During phase I, the meal invariably initiated irregular contractions within 4 min. The phase of MMC during which a caloric meal is ingested modulates duodenal motor response and rate of gastric emptying during the initial postprandial period. Initial postprandial motor activity thus represents the combined effect of nutrient stimulation and the underlying enteric biorhythm as reflected by phase of MMC.

show abstract

Section: Discussionsupporting

confidence: 59%

The migrating motor complex modulates intestinal motility response and rate of gastric emptying of caloric meals

Medhus

Sandstad

Bredesen

et al. 1995

Neurogastroenterology Motil

View full text Add to dashboard Cite

show abstract

“…All dogs were given post-operative analgesic therapy (buprenorphine, 0-02 mg/kg) for 24 h and a 5-day course of antibiotics (amoxycillin trihydrate, 8 mg/kg). The details of the cannulae and the care of the animals has been published previously (Bull, Grundy & Scratcherd, 1987).…”

Section: Surgerymentioning

confidence: 99%

Pre‐pyloric Mechanisms Regulating Gastric Motor Function in the Conscious Dog

Grundy¹,

Hutson²,

Rudge³

et al. 1989

Exp Physiol

View full text Add to dashboard Cite

SUMMARYReflex mechanisms regulating gastric motor function were studied in four conscious dogs, whose stomachs had been surgically divided into separate corporal and antral pouches. Interactions between the corpus and antrum were investigated in fasted animals by balloon distension of each region. During the quiescent phase (phase I) of the migrating motor complex (MMC), distending the corpus with volumes greater than 80 ml resulted in contractions of the corpus, which persisted for as long as the distending stimulus was applied. This corporal distension also initiated antral contractions which were greater if the antrum was moderately distended and also greater with a larger corporal distending volume up to 300 ml. Graded 5 ml inflation of the antrum during the quiescent phase of the MMC stimulated antral contractions. This antral response to antral distension was augmented when the corpus was inflated but was only statistically significant with antral volumes below 25 ml. Distension of the antrum with volumes > 12-5 ml caused inhibition of corporal contractions during both the active phase of a migrating complex or when stimulated by corporal inflation. The degree of inhibition was proportional to the distending stimulus and was present for the duration of the applied distension. For antral volumes of 50 ml the inhibition persisted for a variable time after the stimulus was withdrawn. The inhibition of corporal activity by antral distension was still effective after blocking acid secretion with cimetidine (100 mg), which would eliminate spillage of acid into the jejunum as a cause of the inhibition. It is concluded that pre-pyloric mechanisms co-ordinate corporal and antral motor activity and would operate during gastric emptying to provide a controlled delivery of chyme to the duodenum.

show abstract

“…Details of the surgery, post-operative care and animal husbandry have been described previously (Bull, Grundy & Scratcherd, 1987;Grundy et al 1989). …”

Section: Methodsmentioning

confidence: 99%

“…The experiments were performed on six unanaesthetized healthy dogs (weight 20-25 kg) which had been prepared with a divided stomach, corporal and antral fistulae and a gastrojejunostomy. Details of the surgery, post-operative care and animal husbandry have been described previously (Bull, Grundy & Scratcherd, 1987;Grundy et al 1989).…”

Section: Methodsmentioning

confidence: 99%

Reflex co‐ordination of corporal and antral contractions in the conscious dog

Rudge¹,

Grundy²,

Hutson³

et al. 1990

Experimental Physiology

Self Cite

View full text Add to dashboard Cite

SUMMARYThis study characterizes the role of extrinsic nerves in the co-ordination of corporal and antral contractions in the dog. Fasting motor activity was recorded in conscious dogs with stomachs previously divided into separate corporal and antral pouches. Both corpus and antrum showed synchronized phases of activity and quiescence recognizable as migrating motor complexes (MMCs, duration 81-2 + 9-6 min, n = 4). Moreover, individual contractions were temporally linked such that corpus contractions, occurring at 76+4 s intervals, were each followed by a burst of one to three antral contractions at a frequency of 4-5 min-'. The mean latency between the onset of individual contractions in the corpus and antrum was 109 + 2-6 s (n = 4). Denervation of the antral pouch in two additional dogs did not affect the MMC cycle (mean durations 106-6 and 82 1 min) and the onset of activity in the corpus and antrum was generally co-ordinated but less precise. However, individual antral contractions were no longer linked to corporal contractions, occurring randomly throughout the corpus contraction cycle. This was associated with a lower contraction frequency in the denervated antral pouches than in the corpus (0 3 + 0-1 min-' compared to 0 6 + 0 08 min-'). It is proposed that a vagal reflex, excited by corporal tension receptors, provides phasic excitation facilitating the generation of antral contractions. Such a reflex is likely to reinforce the myogenic mechanisms which occur in the intact stomach and thus plays a role in co-ordinating gastric peristalsis.

show abstract

Disruption of the jejunal migrating motor complex by gastric distension and feeding in the dog.

Cited by 8 publications

References 14 publications

The migrating motor complex modulates intestinal motility response and rate of gastric emptying of caloric meals

The migrating motor complex modulates intestinal motility response and rate of gastric emptying of caloric meals

Pre‐pyloric Mechanisms Regulating Gastric Motor Function in the Conscious Dog

Reflex co‐ordination of corporal and antral contractions in the conscious dog

Contact Info

Product

Resources

About