Disruption of the Atrophy-based Functional Network in Multiple Sclerosis Is Associated with Clinical Disability: Validation of a Meta-Analytic Model in Resting-State Functional MRI

Task- and resting-state fMRI studies in multiple sclerosis: From regions to systems and time-varying analysis. Current status and future perspective

“…Decreased RS FC of frontal/executive and cerebellar areas was related to 9HPT performance Tommasin et al, 2020 119 people with MS 42 HC Within-network RS FC was higher in people with MS than in HC for DMN, FPN and ECN, and was related to less severe EDSS scores, better 9HPT and T25FW scores and milder PASAT impairment. Between-network FC and whole-brain RS FC were also lower, but related to worse impairments at the same tests Dekker et al, 2021 295 people with MS 96 HC Event-based model showed an early involvement of DMN centrality changes related to more severe EDSS scores and cognitive progression Chiang et al, 2021 20 people with MS RS FC of areas frequently showing atrophy based on meta -analysis was evaluated. Deviation from optimal in this model was related to EDSS score Cordani et al, 2021 250 people with RRMS 114 people with PMS 144 HC RS FC related to clinical disability only in people with PMS, where increased FC of motor areas predicted EDSS.…”

Invariant structural and functional brain regions associated with tinnitus: A meta-analysis

“…Rather, ALE assesses the spatial proximity of reported coordinates against a null hypothesis of a random distribution of the same volume and quality of data. ALE computes the convergence of findings based solely on location and is blind to magnitude and direction [ 23 ]. Therefore, this modality agnosticism allows ALE the flexibility to integrate findings across imaging methods [ 24 , 25 ], if to do so is logically appropriate.…”

Can Cognitive training Reignite Compensatory Mechanisms in Advanced Multiple Sclerosis Patients? An Explorative Morphological Network Approach

“…Research using Diffusion Tensor Imaging (DTI) found that resting state functional networks were coupled with structural changes and that PwMS presented increased function-structure coupling throughout the progression of the disease (Koubiyr et al, 2020;van Dam et al, 2021). Moreover, findings of resting state functional abnormalities were associated with lesion volumes, cognitive performance and clinical disability (Chiang et al, 2021;Rocca et al, 2018). However, the effects of cognitive rehabilitation on structural neuroplastic changes are still inconsistent (Prosperini et al, 2015).…”