Disruption of spermatogenesis and differential regulation of testicular estrogen receptor expression in mice after polychlorinated biphenyl exposure

Cai, Jiali; Wang, Chonggang; Wu, Tian; Moreno, João Manuel Lopes; Zhong, Yuanfu; Huang, Xin; Chen, Yixin; Zuo, Zhenghong

doi:10.1016/j.tox.2011.05.010

Cited by 38 publications

(31 citation statements)

References 52 publications

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“…Although links between PCBs and male fertility disruption have been demonstrated in animal models [4][5][6] and cross-sectional human studies mostly support this evidence, some contradicting findings also exist [8]. Bearing in mind the various exposure levels and durations in studied humans, animal models and arctic wildlife, we suggest that the actual impact of PCBs on male fertility in free-ranging animals needs to be researched further.…”

Section: Discussionmentioning

confidence: 80%

“…Cai et al [5] published data on hepatic PCB tissue residues and associated increases in the percentage of abnormal sperm in mice after their oral exposure to Aroclor 1254. We fitted the published data points with an exponential function to obtain a dose-response relationship of the P PCB concentration C (mg g…”

Section: Methodsmentioning

confidence: 99%

“…PCBs also affect the levels of reproductive hormones in male rodents [5,6] and humans [8]. An influence of PCBs and other organochlorine compounds on the levels of some androgenic hormones has been reported for male polar bears, too [9,10].…”

Section: Introductionmentioning

confidence: 99%

“…The subcutaneous lipid P PCB concentrations of polar bear males were assigned based on age following [3] (see electronic supplementary material, table S1 for parameter values and electronic supplementary material, table S2 for the relationship). Owing to limited data availability, it was impossible to account for any possible differences in composition of P PCB mixtures in [5] and [3]. In order to obtain hepatic concentrations to match the units of the dose-response relationship we divided the subcutaneous lipid concentrations by a factor of 1.7 following [30].…”

mentioning

confidence: 99%

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Allee effect in polar bears: a potential consequence of polychlorinated biphenyl contamination

et al. 2016

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Polar bears (Ursus maritimus) from East Greenland and Svalbard exhibited very high concentrations of polychlorinated biphenyls (PCBs) in the 1980s and 1990s. In Svalbard, slow population growth during that period was suspected to be linked to PCB contamination. In this case study, we explored how PCBs could have impacted polar bear population growth and/or male reproductive success in Svalbard during the mid-1990s by reducing the fertility of contaminated males. A dose-response relationship linking the effects of PCBs to male polar bear fertility was extrapolated from studies of the effects of PCBs on sperm quality in rodents. Based on this relationship, an individualbased model of bear interactions during the breeding season predicted fertilization success under alternative assumptions regarding male-male competition for females. Contamination reduced pregnancy rates by decreasing the availability of fertile males, thus triggering a mate-finding Allee effect, particularly when male-male competition for females was limited or when infertile males were able to compete with fertile males for females. Comparisons of our model predictions on age-dependent reproductive success of males with published empirical observations revealed that the low representation of 10-14-year-old males among breeding males documented in Svalbard in mid-1990s could have resulted from PCB contamination. We conclude that contamination-related male infertility may lead to a reduction in population growth via an Allee effect. The magnitude of the effect is largely dependent on the population-specific mating system. In eco-toxicological risk assessments, appropriate consideration should therefore be given to negative effects of contaminants on male fertility and male mating behaviour.

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Section: Discussionmentioning

confidence: 80%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Allee effect in polar bears: a potential consequence of polychlorinated biphenyl contamination

et al. 2016

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“…The main effort of experimental and epidemiological studies so far has been to survey the effects of chronic exposure to PCBs [10], [11]. However, information on female reproductive toxicity induced by a short-term exposure to PCBs in vivo is not yet available.…”

Section: Introductionmentioning

confidence: 99%

Effects of Aroclor 1254 on In Vivo Oocyte Maturation in the Mouse

et al. 2014

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Polychlorinated biphenyls (PCBs) are stable, lipophilic compounds that accumulate in the environment and in the food chain. Though some studies provided evidence that PCBs had adverse effects on reproductive function, most of these results were from in vitro models. Therefore we investigated the effect of Aroclor 1254 (a commercial PCBs mixture) treatments on in vivo maturation and developmental potential of mouse oocytes. In the present study, female ICR mice were treated with different doses (12.5, 25 and 50 mg/kg) of Aroclor 1254 (a commercial PCB mixture) once every 72 hours by intraperitoneal injection for 9 days. After three treatments of Aroclor 1254, the mice were superovulated to collect oocytes one day after the last exposure. The effects of Aroclor 1254 on oocyte maturation, fertilization, and preimplantation embryonic development were investigated. Immunofluorescence-stained oocytes were observed under a confocal microscope to assess the effects of Aroclor 1254 on spindle morphology. Parthenogenic activation and the incidence of cumulus apoptosis in cumulus-oocyte complexes were observed as well. Oocytes exposed to different doses of Aroclor 1254 in vivo were associated with a significant decrease in outgrowth potential, abnormal spindle configurations, and the inhibition of parthenogenetic activation of ovulated oocytes. Furthermore, the incidence of apoptosis in cumulus cells was increased after exposed to Aroclor 1254. These results may provide reference for the treatment of reproductive diseases such as infertility or miscarriage caused by environmental contaminants.

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Potentially estrogenic polychlorinated biphenyls congeners serum levels and its relation with lung cancer

Recio-Vega

Mendez-Henandez

Gabriel

et al. 2012

J of Applied Toxicology

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Lung cancer is the most common cancer in the world. The main cause of lung cancer is cigarette smoke; however, other important genetic and environmental risk factors play a significant role in the development of lung cancer. Among these factors, occupational and accidental exposure to polychlorinated biphenyls (PCBs) has been associated with an increased risk in lung cancer, suggesting that PCBs could be potent carcinogens. The aim of the present study was to investigate the association between PCB exposure levels, CYP1A1 polymorphisms and the risk of lung cancer. This study enrolled newly diagnosed lung cancer patients. Environmental and occupational information related to the patients studied was collected. Blood samples were taken for the measurement of serum levels of 20 PCB congeners and for CYP1A1 polymorphism analysis. The serum levels of two PCB congeners with potential estrogenic activity were higher in lung cancer patients. The risk of lung cancer was found to correlate with age, gender, smoking history and with agricultural workers, as well as with congener 18. No differences were found in the frequency of CYP1A1 polymorphisms. Furthermore, we did not find a correlation between CYP1A1 polymorphisms and PCB serum levels. The high levels of PCB with estrogenic activity found in our cases, could promote lung cancer inducing cell proliferation in non‐neoplastic and neoplastic lung cells via ERβ; inducing the formation of DNA adducts, producing oxidative stress with the subsequent DNA damage and increasing the endogenous catechol levels by catechol‐O‐methyl transferase (COMT) inhibition. Copyright © 2012 John Wiley & Sons, Ltd.

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Disruption of spermatogenesis and differential regulation of testicular estrogen receptor expression in mice after polychlorinated biphenyl exposure

Cited by 38 publications

References 52 publications

Allee effect in polar bears: a potential consequence of polychlorinated biphenyl contamination

Allee effect in polar bears: a potential consequence of polychlorinated biphenyl contamination

Effects of Aroclor 1254 on In Vivo Oocyte Maturation in the Mouse

Potentially estrogenic polychlorinated biphenyls congeners serum levels and its relation with lung cancer

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