Disruption of seasonal enterovirus and parechovirus detections in the CSF and plasma of children during the COVID-19 pandemic

Lee, Brian; Sasidharan, Anjana; Harrison, Christopher J.; Selvarangan, Rangaraj

doi:10.1016/j.jcv.2023.105381

Cited by 6 publications

(2 citation statements)

References 29 publications

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“…Lower levels of population immunity, especially among younger children, may result in a greater prevalence of disease and potentially more severe infection when the virus circulation resumes. Research conducted in the USA showed a significant disruption in seasonal EV detections during the early phases of the COVID-19 pandemic and a rapid increase in detections during the summer and fall of 2022 [38]. Similar disturbances in EV circulation have been observed in the Netherlands during and after lockdown [39].…”

Section: Discussionmentioning

confidence: 57%

Intensified Circulation of Echovirus 11 after the COVID-19 Pandemic in Poland: Detection of a Highly Pathogenic Virus Variant

Gad,

Kłosiewicz,

Oleksiak

et al. 2024

Viruses

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After the first phase of the COVID-19 pandemic in Europe, a new highly pathogenic variant of echovirus 11 (E11) was detected. The aim of this study was to analyze the genetic diversity of Polish E11 environmental and clinical strains circulating between 2017 and 2023 as well as compare them with E11 strains isolated from severe neonatal sepsis cases reported in Europe between 2022 and 2023. Additionally, the study explores the effectiveness of environmental monitoring in tracking the spread of new variants. For this purpose, the complete sequences of the VP1 capsid protein gene were determined for 266 E11 strains isolated in Poland from 2017 to 2023, and phylogenetic analysis was performed. In the years 2017–2023, a significant increase in the detection of E11 strains was observed in both environmental and clinical samples in Poland. The Polish E11 strains represented three different genotypes, C3, D5 and E, and were characterized by a high diversity. In Poland, the intensive circulation of the new variant E11, responsible for severe neonatal infections with a high mortality in Europe, was detected in the years 2022–2023. This investigation demonstrates the important role of environmental surveillance in the tracking of enteroviruses circulation, especially in settings with limited clinical surveillance.

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Section: Discussionmentioning

confidence: 57%

Intensified Circulation of Echovirus 11 after the COVID-19 Pandemic in Poland: Detection of a Highly Pathogenic Virus Variant

Gad,

Kłosiewicz,

Oleksiak

et al. 2024

Viruses

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“…For the current study, claims data were selected from January 1, 2014, and December 31, 2019. The study period was chosen to exclude the COVID-19 pandemic era to ensure results could be compared across the study years and to exclude irregular RSV-seasons during and after the COVID-19 pandemic (15).…”

Section: Study Design and Data Sourcementioning

confidence: 99%

Clinical and economic burden of lower respiratory tract infection due to respiratory syncytial virus in young children in Germany

Beese,

Bayer,

Huebbe

et al. 2024

Preprint

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Background: Clinical and economic burden of infections due to respiratory syntactical virus (RSV) in children <2 years of age in Germany is still underestimated. Methods: In a retrospective health claims analysis, we identified RSV inpatient and outpatient episodes based on year-round specific RSV ICD-10 diagnoses or unspecified lower respiratory tract infection diagnoses during the RSV-season. High-risk groups were defined by ICD-10 codes. Hospitalization costs per patient were incurred between the beginning and end of an RSV episode. All-cause costs were compared to a matched control group without RSV infections based on age, sex, and prematurity in the inpatient and outpatient sectors. Results The incidence of hospitalization due to RSV was substantially higher in infants (21/1,000) than in toddlers (5.4/1,000). Most hospitalizations occurred in the first six months of life; the highest hospitalization incidences were observed in the second month of life (46/1,000). Infants with risk factors had a 2.4 times higher risk for hospitalization than those without. The economic burden per episode was high in the first 3 months of life and especially for those with risk factors and/or prematurity. However, overall annual resource utilization for the healthcare system was higher for healthy children with no underlying risk factors than for those with risk factors. Conclusion: RSV in children <2 years of age causes a considerable burden for the German healthcare system, both clinically and economically. Newborns, premature infants, children with chronic underlying risk factors are at highest risk for severe outcomes, but the overall disease burden affects healthy infants.

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Severe Disease in Children with Parechovirus-A Infection

Tachikawa

Aizawa

Saitoh

2023

Curr Clin Micro Rpt

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Disruption of seasonal enterovirus and parechovirus detections in the CSF and plasma of children during the COVID-19 pandemic

Cited by 6 publications

References 29 publications

Intensified Circulation of Echovirus 11 after the COVID-19 Pandemic in Poland: Detection of a Highly Pathogenic Virus Variant

Intensified Circulation of Echovirus 11 after the COVID-19 Pandemic in Poland: Detection of a Highly Pathogenic Virus Variant

Clinical and economic burden of lower respiratory tract infection due to respiratory syncytial virus in young children in Germany

Severe Disease in Children with Parechovirus-A Infection

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