Disruption of re-intake after partial withdrawal of gastric food contents in rats lesioned in the gelatinous part of the nucleus of the solitary tract

Zafra, María A.; Agüera, Antonio D.R.; Molina, Filomena; Puerto, Amadeo

doi:10.1016/j.appet.2017.02.040

Cited by 3 publications

(2 citation statements)

References 66 publications

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“…Based on both animal studies and human brain imaging, the regions involved in relaying information of vagal origin to the cortex include, beyond the nucleus of solitary tract, the parabrachial nucleus, and ventrobasal thalamus (Saper, 2000(Saper, , 2002Craig, 2002). Without entering into details, the aforementioned brain relays have been linked to the regulation of satiation and meal size in laboratory animals (Dossat et al, 2013;Alhadeff et al, 2014;Cavanaugh et al, 2015;Campos et al, 2016;Zafra et al, 2017). As early as in the 1930's, studies showed that the electrical stimulation of the vagus nerve altered cortical electrograms (Bailey and Bremer, 1938;O'Brien et al, 1971;Ito and Craig, 2003).…”

Section: Central Viscerosensory Circuitsmentioning

confidence: 99%

The Phantom Satiation Hypothesis of Bariatric Surgery

Gautron

2021

Front. Neurosci.

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The excitation of vagal mechanoreceptors located in the stomach wall directly contributes to satiation. Thus, a loss of gastric innervation would normally be expected to result in abrogated satiation, hyperphagia, and unwanted weight gain. While Roux-en-Y-gastric bypass (RYGB) inevitably results in gastric denervation, paradoxically, bypassed subjects continue to experience satiation. Inspired by the literature in neurology on phantom limbs, I propose a new hypothesis in which damage to the stomach innervation during RYGB, including its vagal supply, leads to large-scale maladaptive changes in viscerosensory nerves and connected brain circuits. As a result, satiation may continue to arise, sometimes at exaggerated levels, even in subjects with a denervated or truncated stomach. The same maladaptive changes may also contribute to dysautonomia, unexplained pain, and new emotional responses to eating. I further revisit the metabolic benefits of bariatric surgery, with an emphasis on RYGB, in the light of this phantom satiation hypothesis.

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Section: Central Viscerosensory Circuitsmentioning

confidence: 99%

The Phantom Satiation Hypothesis of Bariatric Surgery

Gautron

2021

Front. Neurosci.

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“…In fact, this visceral vagal-NSTic-LPBe information pathway also appears to participate in other physiological processes requiring the rapid transmission of nutritional information. We recently showed that both the vagus nerve [136] and SolG [137] or LPBe [138] are essential in circumstances that require the immediate adjustment of food intake, extracting part of ingested food immediately after ending a meal and finding that approximately the same amount was reingested by neurologically intact animals but a much smaller amount by lesioned animals.…”

Section: Transmission Pathways Of Rewarding Visceral Information To Tmentioning

confidence: 99%

Enteral Feeding: Brain-Visceral Interactions in the Processing of Nutrients

Palma¹,

Mahía²,

Simon³

et al. 2019

Feed Your Mind - How Does Nutrition Modulate Brain Function Throughout Life?

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Enteral nutrition is often mandatory, especially for patients in vegetative or minimally conscious state. However, its application is nonviable in certain cases due to various adverse effects. Some of these are explained by absence of the cephalic phase of digestion, during which exocrine, endocrine, and motor physiological responses prepare the digestive system to receive, digest, transform, and utilize ingested nutrients. These responses result from the stimulation by nutrients of cephalic sensory systems, mainly in the oropharyngeal cavity, and can also be elicited by food-related thoughts or expectations. The digestive system appears able to rapidly assess the suitability of food and transmit this information to the brain. The vagus nerve and its brainstem relays in the caudal nucleus of the solitary tract (NST) and parabrachial complex appear to participate in the anatomic pathway responsible for this rapid processing. Thus, blockade of the vagus nerve, NST, or external lateral parabrachial region (LPBe) interrupts expression of conditioned taste preferences induced by administration of "predigested" food, while LPBe activation by electric stimulation generates similar preferences to those observed after cephalic food administration. This review may help design enteral diets better adapted to digestive physiology and develop pharmacological interventions against adverse effects of enteral nutrition.

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