Disruption of predicted dengue virus type 3 major outbreak cycle coincided with switching of the dominant circulating virus genotype

Tan, Kian Lam; Zulkifle, Nurul-Izzani; Abd-Jamil, Juraina; Sulaiman, Sofiah; Yaacob, Che Norainon; Azizan, Noor Syahida; Seri, Nurul Asma Anati Che Mat; Samsudin, Nur Izyan; Mahfodz, Nur Hidayana; AbuBakar, Sazaly

doi:10.1016/j.meegid.2017.07.008

Cited by 16 publications

(26 citation statements)

References 14 publications

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“…The existing trend contended that serotype replacement, most probably with DENV 3 is predicted to take place once the current outbreak subsides. In contrast to our prediction, Tan et al (2017) reported the unlikeliness for DENV 3 to surge as serotype cyclical outbreak cycle in Malaysia has recently been disrupted with DENV 3 remained in the background of DENV 1 and DENV 2 from 2003 until now [ 15 ].…”

Section: Discussioncontrasting

confidence: 99%

“…The DENV 3 strains in our study were divided into genotype I and genotype III. Genotype III was constantly documented in Malaysia from 2007–2013 [ 15 , 19 ]. Interestingly, genotype I of DENV 3 was last documented in 2011 and also circulated in this country during dengue epidemics in 1974 and 2007–2008 [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…Genotype III was constantly documented in Malaysia from 2007–2013 [ 15 , 19 ]. Interestingly, genotype I of DENV 3 was last documented in 2011 and also circulated in this country during dengue epidemics in 1974 and 2007–2008 [ 15 ]. Hence, the appearance of genotype I that was equal to genotype III among DENV 3 strains in our study raised the possibility of re-emergence of genotype I especially during outbreaks.…”

Section: Discussionmentioning

confidence: 99%

“…It is known that severe dengue is associated with secondary infection and infection with DENV 2 superimposed on previous DENV 1 infection carries the highest risk for development of severe dengue [ 30 ]. Even though the DENV 3 upsurge after the current outbreak is predicted, however as mentioned earlier, one study [ 15 ] has cautioned that this cycle was recently disrupted, raising the possibility for DENV 2 dominance. Therefore, our study findings on the high prevalence of primary infection is very crucial in the conveyance of early warning for a severe outbreak in the future.…”

Section: Discussionmentioning

confidence: 99%

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Clinical manifestations of dengue in relation to dengue serotype and genotype in Malaysia: A retrospective observational study

et al. 2018

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BackgroundMalaysia experienced an unprecedented dengue outbreak from the year 2014 to 2016 that resulted in an enormous increase in the number of cases and mortality as compared to previous years. The causes that attribute to a dengue outbreak can be multifactorial. Viral factors, such as dengue serotype and genotype, are the components of interest in this study. Although only a small number of studies investigated the association between the serotype of dengue virus and clinical manifestations, none of these studies included analyses on dengue genotypes. The present study aims to investigate dengue serotype and genotype-specific clinical characteristics among dengue fever and severe dengue cases from two Malaysian tertiary hospitals between 2014 and mid-2017.Methodology and principal findingsA total of 120 retrospective dengue serum specimens were subjected to serotyping and genotyping by Taqman Real-Time RT-PCR, sequencing and phylogenetic analysis. Subsequently, the dengue serotype and genotype data were statistically analyzed for 101 of 120 corresponding patients’ clinical manifestations to generate a descriptive relation between the genetic components and clinical outcomes of dengue infected patients. During the study period, predominant dengue serotype and genotype were found to be DENV 1 genotype I. Additionally, non-severe clinical manifestations were commonly observed in patients infected with DENV 1 and DENV 3. Meanwhile, patients with DENV 2 infection showed significant warning signs and developed severe dengue (p = 0.007). Cases infected with DENV 2 were also commonly presented with persistent vomiting (p = 0.010), epigastric pain (p = 0.018), plasma leakage (p = 0.004) and shock (p = 0.038). Moreover, myalgia and arthralgia were highly prevalent among DENV 3 infection (p = 0.015; p = 0.014). The comparison of genotype-specific clinical manifestations showed that DENV 2 Cosmopolitan was significantly common among severe dengue patients. An association was also found between genotype I of DENV 3 and myalgia. In a similar vein, genotype III of DENV 3 was significantly common among patients with arthralgia.ConclusionThe current data contended that different dengue serotype and genotype had caused distinct clinical characteristics in infected patients.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Clinical manifestations of dengue in relation to dengue serotype and genotype in Malaysia: A retrospective observational study

et al. 2018

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“…Surveillance information regarding which virus serotypes and genotypes were circulating in Sabah was not available in this study, so we were unable to assess the potential contribution of virus circulation patterns to the trends we observed. Assessing serological surveillance data alongside epidemiological data in future studies in Sabah could aid predictions of severe disease risk (59, 60).…”

Section: Discussionmentioning

confidence: 99%

Spatial and epidemiologic features of dengue in Sabah, Malaysia

Murphy

Rajahram

Jilip

et al. 2019

Preprint

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3435 In South East Asia, dengue epidemics have increased in size and geographical distribution in 36 recent years. Most studies investigating dengue transmission and control have had an urban 37 focus, while less consideration is currently given to rural settings, or where urban and rural 38 areas overlap. We examined the spatiotemporal distribution and epidemiological 39 characteristics of reported dengue cases in the predominantly rural state of Sabah, in 40 Malaysian Borneo -an area where sylvatic and urban circulation of pathogens are known to 41 intersect. We found that annual dengue incidence rates were spatially variable over the 7-42 year study period from 2010-2016 (state-wide mean annual incidence of 21 cases/100,000 43 people; range 5-42/100,000), but were highest in rural localities in the western districts of 44 the state (Kuala Penyu, Nabawan, Tenom and Kota Marudu). The eastern districts exhibited 45 lower overall dengue rates; however, we noted a concentration of severe (haemorrhagic) 46 dengue cases (44%) in Sandakan and Tawau districts. Dengue incidence was slightly higher 47 for males than females, and was significantly higher for both genders aged between 10 and 48 29 years (24/100,000; p=0.029). The largest ever recorded outbreaks occurred during 2015-49 2016, with the vector Aedes albopictus found to be most prevalent in both urban and rural 50 households (House Index of 64%), compared with Ae. Aegypti (15%). These findings suggest 51 that dengue outbreaks in Sabah are driven by the sporadic expansion of dengue virus in both 52 urban and rural settings. This may require tailoring of preventative strategies to suit 53 different transmission ecologies across Sabah. Further studies to better understand the 54 drivers of dengue in Sabah may aid dengue control efforts in Malaysia, and more broadly in 55 South East Asia.3 56 Author summary 57 58 In order to combat the rising regional incidence of dengue in South East Asia, the drivers of 59 transmission must be better characterised across different environmental settings. We 60 conducted the first retrospective analysis of dengue epidemiology in the predominantly rural 61 state of Sabah, Malaysia, where both urban and sylvatic transmission cycles exist. Human 62 notification data over a 7-year period were reviewed and spatiotemporal and demographic 63 risk factors identified. We found: 64 1. Urban habitats and population density are not the only determinants mediating the 65 spread of epidemic dengue in Sabah. Case from both urban and rural localities 66 contributed equally to dengue outbreaks. 67 2. Human demographic risk factors included being aged between 10 and 29 years, and 68 being male. 69 3. High incidence areas for dengue do not predict the occurrence of severe dengue. Severe 70 dengue was largely localised to lower incidence districts in the east of the state. 71 4. The sole presence of Aedes albopictus in and around the majority of urban and rural 72 case households suggests that this vector may play a major role in facilitating outbr...

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The phylogenomics of flaviviruses

Li,

Wang

2024

Phylogenomics

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Disruption of predicted dengue virus type 3 major outbreak cycle coincided with switching of the dominant circulating virus genotype

Cited by 16 publications

References 14 publications

Clinical manifestations of dengue in relation to dengue serotype and genotype in Malaysia: A retrospective observational study

Clinical manifestations of dengue in relation to dengue serotype and genotype in Malaysia: A retrospective observational study

Spatial and epidemiologic features of dengue in Sabah, Malaysia

The phylogenomics of flaviviruses

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