Disruption of posterior brain functional connectivity and its relation to cognitive impairment in idiopathic REM sleep behavior disorder

Campabadal, Anna; Abós, Alexandra; Segura, Bàrbara; Serradell, Mónica; Uribe, Carme; Baggio, Hugo C.; Gaig, Carles; Santamaría, Joan; Compta, Yaroslau; Bargalló, Núria; Junqué, Carme; Iranzo, Álex

doi:10.1016/j.nicl.2019.102138

Cited by 43 publications

(67 citation statements)

References 50 publications

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“…While previous nigrocortical and cortico-cortical connectivity studies using resting state fMRI have reported left lateralized connectivity changes ( 38 , 50 , 70 ) consistent with left hemispheric predominance of nigrostriatal dysfunction ( 71 ), the laterality of connectivity results in the present study require further investigation. Laterality of disease onset is determined by neurologic exam and it is only possible to make these clinical determinations for the PD patients who show motor impairment.…”

Section: Discussioncontrasting

confidence: 39%

“…The physiological relevance of the altered functional connectivity between SN and lingual gyrus in RBD and PD found in the present study requires further investigation. A recent resting state fMRI reports reduced brain functional connectivity with a multiple posterior cortical regions in RBD patients in whom the connectivity changes correlated with mental processing slowness ( 50 ). Earlier studies using metabolic PET imaging ( 68 ) and corticometry ( 49 ) specifically implicate the lingual gyrus as one posterior cortical area showing reduced glucose tracer uptake and cortical thinning respectively in RBD vs. healthy controls.…”

Section: Discussionmentioning

confidence: 99%

“…Neuroimaging studies show that RBD is associated with altered striatal dopaminergic innervation ( 45 , 46 ), striatal volumetric differences ( 47 ), and reduced nigrostriatal and nigrocortical resting state functional connectivity ( 38 ). More recent neuroimaging studies including structural MRI, [18F]fluorodeoxyglucose PET, and fMRI resting state connectivity implicate posterior cortical regions, including lingual gyrus, in PD and RBD ( 37 , 48 – 50 ). A large proportion of patients develop Parkinson's disease years after the diagnosis of their RBD ( 51 , 52 ).…”

Section: Introductionmentioning

confidence: 99%

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A Study of the Relationship Between Uric Acid and Substantia Nigra Brain Connectivity in Patients With REM Sleep Behavior Disorder and Parkinson's Disease

Ellmore

Suescun²,

Castriotta

et al. 2020

Front. Neurol.

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Low levels of the natural antioxidant uric acid (UA) and the presence of REM sleep behavior disorder (RBD) are both associated with an increased likelihood of developing Parkinson's disease (PD). RBD and PD are also accompanied by basal ganglia dysfunction including decreased nigrostriatal and nigrocortical resting state functional connectivity. Despite these independent findings, the relationship between UA and substantia nigra (SN) functional connectivity remains unknown. In the present study, voxelwise analysis of covariance was used in a cross-sectional design to explore the relationship between UA and whole-brain SN functional connectivity using the eyes-open resting state fMRI method in controls without RBD, patients with idiopathic RBD, and PD patients with and without RBD. The results showed that controls exhibited a positive relationship between UA and SN functional connectivity with left lingual gyrus. The positive relationship was reduced in patients with RBD and PD with RBD, and the relationship was found to be negative in PD patients. These results are the first to show differential relationships between UA and SN functional connectivity among controls, prodromal, and diagnosed PD patients in a ventral occipital region previously documented to be metabolically and structurally altered in RBD and PD. More investigation, including replication in longitudinal designs with larger samples, is needed to understand the pathophysiological significance of these changes.

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Section: Discussioncontrasting

confidence: 39%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Study of the Relationship Between Uric Acid and Substantia Nigra Brain Connectivity in Patients With REM Sleep Behavior Disorder and Parkinson's Disease

Ellmore

Suescun²,

Castriotta

et al. 2020

Front. Neurol.

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“…To date, there is a considerable amount of neuroimaging research showing structural ( Campabadal et al, 2019b , De Marzi et al, 2016 , Ehrminger et al, 2016 , Ellmore et al, 2010 , Hanyu et al, 2012 , Ohlhauser et al, 2019 , Park et al, 2018 , Pereira et al, 2019 , Pyatigorskaya et al, 2017 , Rahayel et al, 2015 , Rahayel et al, 2018a , Rahayel et al, 2018b , Scherfler et al, 2011 , Unger et al, 2010 ) and functional ( Byun et al, 2020 , Campabadal et al, 2020 , Dayan and Browner, 2017 , Ellmore et al, 2013 , Park et al, 2018 , Rolinski et al, 2016 ) abnormalities in IRBD patients using MRI. Most importantly, owing to all these works, there is strong evidence that brain changes relate to cognitive impairment ( Byun et al, 2020 , Campabadal et al, 2020 , Pereira et al, 2019 , Rahayel et al, 2018b , Vendette et al, 2012 ) and olfactory loss ( Campabadal et al, 2019a , Pereira et al, 2019 , Rahayel et al, 2018b , Vendette et al, 2011 ). Nevertheless, few researchers have investigated how the disease progression affects brain structure and function, and how these changes are associated with cognitive decline.…”

Section: Introductionmentioning

confidence: 99%

Cortical gray matter progression in idiopathic REM sleep behavior disorder and its relation to cognitive decline

Campabadal

Inguanzo

Segura

et al. 2020

NeuroImage: Clinical

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Highlights Cortical degeneration over time in IRBD patients is larger than in normal aging. IRBD patients have progressive parieto-occipital and orbitofrontal thinning. Visuospatial decline in IRBD is associated with degeneration in parietal regions. Increasing motor signs in IRBD are related to frontal and parietal degeneration. Cortical thinning in posterior regions is associated with late-onset IRBD.

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“…Suo found the configurations of brain functional network in PD were perturbed and correlated with the severity of the disease (17). And another study found idiopathic RBD (iRBD) patients had reduced centrality in left superior parietal lobule when compared with healthy controls (18). However, the mechanism of overall brain functional network regulation and property changes in PD-RBD patients is still unknown.…”

Section: Introductionmentioning

confidence: 99%

Altered Brain Functional Network in Parkinson Disease With Rapid Eye Movement Sleep Behavior Disorder

Zeng

Zhou

et al. 2020

Front. Neurol.

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Background and Objective: Parkinson disease (PD) with rapid eye movement (REM) sleep behavior disorder (PD-RBD) tend to be a distinct phenotype with more severe clinical characteristics and pathological lesion when compared with PD without RBD (PD-nRBD). However, the pathological mechanism underlying PD-RBD remains unclear. We aim to use the resting-state functional magnetic resonance imaging (rs-fMRI) to explore the mechanism of PD-RBD from the perspective of internal connectivity networks. Materials and Methods: A total of 92 PD patients and 20 age and sex matched normal controls (NC) were included. All participants underwent rs-fMRI scan and clinical assessment. According to the RBD screening questionnaire (RBDSQ), PD patients were divided into two groups: PD with probable RBD (PD-pRBD) and PD without probable RBD (PD-npRBD). The whole brain was divided into 90 regions using automated anatomic labeling atlas. Functional network of each subject was constructed according to the correlation of rs-fMRI blood oxygenation level dependent signals in any two brain regions and network metrics were analyzed using graph theory approaches. Network properties among three groups were compared and correlation analysis was made using distinguishing network metrics and RBDSQ scores. Results: We found both PD-pRBD and PD-npRBD patients existed small-world characteristics. PD-pRBD showed a wider range of nodal property changes in neocortex and limbic system than PD-npRBD patients when compared with NC. Besides, PD-pRBD showed significant enhanced nodal efficiency in the bilateral thalamus and betweenness centrality in the left insula, but, reduced betweenness centrality in the right dorsolateral superior frontal gyrus when compared with PD-npRBD. Moreover, nodal efficiency in the bilateral thalamus were positively correlated with RBDSQ scores. Conclusions: Both NC and PD patients displayed small-world properties and indiscriminate global measure but PD-pRBD showed more extensive changes of nodal properties than PD-npRBD. The increased centrality role in the bilateral thalamus and the left insula, and disruption in the right dorsolateral superior frontal gyrus may play as a key role in underlying pathogenesis of PD-RBD.

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Disruption of posterior brain functional connectivity and its relation to cognitive impairment in idiopathic REM sleep behavior disorder

Cited by 43 publications

References 50 publications

A Study of the Relationship Between Uric Acid and Substantia Nigra Brain Connectivity in Patients With REM Sleep Behavior Disorder and Parkinson's Disease

A Study of the Relationship Between Uric Acid and Substantia Nigra Brain Connectivity in Patients With REM Sleep Behavior Disorder and Parkinson's Disease

Cortical gray matter progression in idiopathic REM sleep behavior disorder and its relation to cognitive decline

Altered Brain Functional Network in Parkinson Disease With Rapid Eye Movement Sleep Behavior Disorder

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