Wen-Jian Jiang, Wei-Hong Ren, Xu-Jie Liu, Yan Liu, Fu-Jian Wu, Li-Zhong Sun, Feng Lan, Jie Du, Hong-Jia Zhang
Abstract:In this study, we assessed whether the down-regulation of Yes-associated protein (YAP) is involved in the pathogenesis of extracellular matrix (ECM) mechanical stress-induced Stanford type A aortic dissection (STAAD). Human aortic samples were obtained from heart transplantation donors as normal controls and from STAAD patients undergoing surgical replacement of the ascending aorta. Decreased maximum aortic wall velocity, ECM disorders, increased VSMC apoptosis, and YAP down-regulation were identified in STAAD…
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