Disruption of Male Reproductive Tract Development by Administration of the Xenoestrogen, Nonylphenol, to Male Newborn Rats

Lee, Ping C.

doi:10.1385/endo:9:1:105

Cited by 94 publications

(56 citation statements)

References 26 publications

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“…During anaerobic sewage digestion, alkylphenol polyethoxylates are biodegraded by hydrolytic removal of ethoxylate groups forming short-chain ethoxylates, carboxylic acid derivatives and nonylphenols [8]. NP possesses oestrogenic properties and has been shown to disrupt the male reproductive system of fish, reptiles and mammals [9][10][11]. The residual nature of nonylphenol and its lipophilic character leads to its accumulation in the lipids of living organisms [7,12,13].…”

Section: Introductionmentioning

confidence: 99%

Combined action of X-rays and nonylphenol on mouse sperm

Dobrzyńska

2011

Open Life Sciences

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The aim of this study was to assess the effects of 2-weeks’ X-ray and/or nonylphenol (NP) exposure on male mice’s sperm count and quality. Pzh:SFIS mice were exposed to X-rays (0.05 Gy, 0.10 Gy, 0.20 Gy) or to nonylphenol (25 mg/kg bw, 50 mg/kg bw, 100 mg/kg bw) or to both agents (0.05 Gy + 25 mg/kg bw NP, 0.10 Gy + 50 mg/kg bw NP). At 24 h and 5 weeks after the end of exposure the sperm count, morphology and frequency of DNA damage in the male germ cells were estimated. Each agent alone diminished sperm count and morphology. The dose of 0.05 Gy of X-rays decreased the frequency of DNA damage. Combined exposure to lower doses of both agents significantly improved sperm morphology and decreased the level of DNA damage compared to one agent alone. Combined exposure to higher doses reduced the frequency of DNA damage compared to the effect of the appropriate dose of NP. Results of combined exposure to low doses of both agents suggest that 0.05 Gy of X-rays stimulate the DNA damagecontrol system and in consequence repair of DNA caused by X-rays and NP. It may be correlated with increased antioxidant capacity.

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Section: Introductionmentioning

confidence: 99%

Combined action of X-rays and nonylphenol on mouse sperm

Dobrzyńska

2011

Open Life Sciences

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“…However, a few studies indicate that NP may also increase endogenous steroid receptor ligand levels (Thibaut & Porte 2004, Acevedo et al 2005, Soverchia et al 2005, begging the question of whether NP activates the receptors directly or indirectly by increasing estrogen levels in the blood. The fact that the estrogenic effects induced by NP are inhibited by ER antagonists, suggests that NP is working at least in part via ERs (Lee 1998, Wilson et al 2004. The use of ER antagonists in fish model systems has been minimally explored (Latonnelle et al 2002, Hornung et al 2003, Radice et al 2004.…”

Section: Introductionmentioning

confidence: 99%

Distinct expression and activity profiles of largemouth bass (Micropterus salmoides) estrogen receptors in response to estradiol and nonylphenol

Sabo‐Attwood

Blum

Kroll

et al. 2007

Journal of Molecular Endocrinology

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The estrogen receptor (ER) signaling cascade is a vulnerable target of exposure to environmental xenoestrogens, like nonylphenol (NP), which are causally associated with impaired health status. However, the impact of xenoestrogens on the individual receptor isotypes (a, ba, and bb) is not well understood. The goal of these studies was to determine the impact of NP on largemouth bass (Micropterus salmoides) ER isotype expression and activity. Here, we show that hepatic expression levels of three receptors are not equivalent in male largemouth bass exposed to NP by injection. Transcript levels of the ERa subtype were predominantly induced in concert with vitellogenin similarly to fish exposed to 17b-estradiol (E 2 ) as measured by quantitative real-time PCR. NP also induced circulating plasma levels of estrogen, which may contribute to overall activation of the ERs. To measure the activation of each receptor isotype by E 2 and NP, we employed reporter assays using an estrogen response element (ERE)-luciferase construct. Results from these studies show that ERa had the greatest activity following exposure to E 2 and NP. This activity was inhibited by the antagonists ICI 182 780 and ZM 189 154. Furthermore, both bb and ba subtypes depressed ERa activation, suggesting that the cellular composition of receptor isotypes may contribute to the overall actions of estrogen and estrogenic contaminants via the receptors. Results from these studies collectively reveal the differential response of fish ER isotypes in response to xenoestrogens.

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“…While unique and/or higher toxicity of some chemicals in infants has recently been reported (Lee, 1998;Khan et al, 1998;Katsuda et al, 2000), there is no systematic toxicity study protocol to examine direct toxic effects of chemicals in newborn animals. Although the results of one-and/or two-generation studies might reflect the toxicity of chemicals in infants exposed from the neonatal period to weaning, the exposure occurs only via their maternal milk.…”

Section: Introductionmentioning

confidence: 99%

Comparative Toxicity Study of 3-Aminophenol in Newborn and Young Rats

et al. 2002

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-Repeated dose toxicity of 3-aminophenol was examined on oral administration to newborn and young rats, and susceptibility was analyzed in terms of the no observed adverse effect level (NOAEL) and the unequivocally toxic level. In the 18-day newborn rat study, starting at day 4 after birth, tremors and depression of body weight gain were observed, as well as hypertrophy of thyroid follicular epithelial cells and increases of relative liver and kidney weights at 240 mg/kg. Increase of relative liver weights in males and decrease of blood sugar in females without any histopathological changes at 80 mg/ kg were not considered to be adverse effects. No chemical-related changes were observed at 24 mg/kg. Abnormalities of external development and reflex ontogeny in the newborn were not observed. In the 28-day study, starting at 5 weeks of age, depression of body weight gain, tremors, anemia, and liver, kidney and thyroid toxicity were observed at 720 mg/kg. Although slight pigmentation in the renal proximal tubular epithelium was observed in females at 240 mg/kg, this was not considered to be an adverse effect because of the lack of changes in related toxicological parameters. It was concluded that the NOAEL is 80 mg/kg/day in newborn rats and 240 mg/kg/day in young rats, with unequivocally toxic levels of 240 mg/kg/day and 720 mg/kg/day, respectively. Based on these two endpoints, the susceptibility of newborn rats to the chemical was approx. 3 times higher than that of young rats, consistent with our previous results for 4-nitrophenol and 2,4-dinitrophenol.

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Disruption of Male Reproductive Tract Development by Administration of the Xenoestrogen, Nonylphenol, to Male Newborn Rats

Cited by 94 publications

References 26 publications

Combined action of X-rays and nonylphenol on mouse sperm

Combined action of X-rays and nonylphenol on mouse sperm

Distinct expression and activity profiles of largemouth bass (Micropterus salmoides) estrogen receptors in response to estradiol and nonylphenol

Comparative Toxicity Study of 3-Aminophenol in Newborn and Young Rats

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