Disruption of<i>Nectin-Like 1</i>Cell Adhesion Molecule Leads to Delayed Axonal Myelination in the CNS

Park, Jin‐Sil; Liu, Ben; Chen, Tao; Li, Hong; Hu, Xuemei; Gao, Jing; Zhu, Ying; Zhu, Qiang; Qiang, Boqin; Yuan, Jing; Peng, Xiaozhong; Qiu, Mengsheng

doi:10.1523/jneurosci.2665-08.2008

Cited by 60 publications

(67 citation statements)

References 22 publications

(53 reference statements)

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“…Necls/SynCAMs were shown to be involved in late stages of neural circuit formation, in particular synaptogenesis (Biederer et al, 2002) and myelination in the peripheral (Maurel et al, 2007;Spiegel et al, 2007) and the central nervous system (Park et al, 2008). Here, we demonstrate that Necls/SynCAMs are also involved in early steps of neural circuit formation in the chick spinal cord in vivo.…”

Section: Discussionmentioning

confidence: 55%

“…Furthermore, some Necl family members were identified as tumor suppressor genes, called Tslc (tumor suppressor in lung cancer) and Tsll (Tslc-like) (reviewed in Takai et al, 2003). More recently, Necl1/SynCAM3 and Necl4/SynCAM4 were shown to be required for myelination in the peripheral and the central nervous system (Maurel et al, 2007;Park et al, 2008;Spiegel et al, 2007). Very little is known about the role of Necl3/SynCAM2.…”

Section: Introductionmentioning

confidence: 99%

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Nectin-like molecules/SynCAMs are required for post-crossing commissural axon guidance

et al. 2010

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SUMMARYThe Necl/SynCAM subgroup of immunoglobulin superfamily cell adhesion molecules has been implicated in late stages of neural circuit formation. They were shown to be sufficient for synaptogenesis by their trans-synaptic interactions. Additionally, they are involved in myelination, both in the central and the peripheral nervous system, by mediating adhesion between glia cells and axons. Here, we show that Necls/SynCAMs are also required for early stages of neural circuit formation. We demonstrate a role for Necls/SynCAMs in post-crossing commissural axon guidance in the developing spinal cord in vivo. Necl3/SynCAM2, the family member that has not been characterized functionally so far, plays a crucial role in this process. It is expressed by floorplate cells and interacts with Necls/SynCAMs expressed by commissural axons to mediate a turning response in post-crossing commissural axons.

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Section: Discussionmentioning

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Nectin-like molecules/SynCAMs are required for post-crossing commissural axon guidance

et al. 2010

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“…G ratio, an indicator of the myelin sheath thickness, is restored to normal levels in Tag-1 Ϫ/Ϫ ;plp mice, suggesting that glial TAG-1 positively regulates the myelination process in the CNS. Therefore, TAG-1 may be added to the list of a small number of proteins (PDGF␣, WAVE-1, NogoA, neuregulin 1 nectin-like 1) that affect the level of myelination in CNS fibers apart from those that influence the myelin structure such as MBP and PLP (Popko et al, 1987;Griffiths et al, 1998;Fruttiger et al, 1999;Kim et al, 2006;Brinkmann et al, 2008;Park et al, 2008;Pernet et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

The Expression of TAG-1 in Glial Cells Is Sufficient for the Formation of the Juxtaparanodal Complex and the Phenotypic Rescue of Tag-1 Homozygous Mutants in the CNS

Savvaki¹,

Theodorakis²,

Zoupi³

et al. 2010

J. Neurosci.

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“…Axonal SynCAM1 and SynCAM3 interact with SynCAM4 on Schwann cells to promote myelination in the PNS (Maurel et al, 2007;Spiegel et al, 2007). In the CNS, SynCAM2 and SynCAM3 have been implicated in myelination, although their detailed expression in axons versus glia is not clear yet (Kakunaga et al, 2005;Park et al, 2008;Pellissier et al, 2007). However, a role in earlier aspects of neural circuit formation had not been considered.…”

Section: Syncams Are Axon Guidance Moleculesmentioning

confidence: 99%

SynCAMs – From axon guidance to neurodevelopmental disorders

Frei

Stoeckli

2017

Molecular and Cellular Neuroscience

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Many cell adhesion molecules are located at synapses but only few of them can be considered synaptic cell adhesion molecules in the strict sense. Besides the Neurexins and Neuroligins, the LRRTMs (leucine rich repeat transmembrane proteins) and the SynCAMs/CADMs can induce synapse formation when expressed in non-neuronal cells and therefore are true synaptic cell adhesion molecules. SynCAMs (synaptic cell adhesion molecules) are a subfamily of the immunoglobulin superfamily of cell adhesion molecules. As suggested by their name, they were first identified as cell adhesion molecules at the synapse which were sufficient to trigger synapse formation. They also contribute to myelination by mediating axon-glia cell contacts. More recently, their role in earlier stages of neural circuit formation was demonstrated, as they also guide axons both in the peripheral and in the central nervous system. Mutations in SynCAM genes were found in patients diagnosed with autism spectrum disorders. The diverse functions of SynCAMs during development suggest that neurodevelopmental disorders are not only due to defects in synaptic plasticity. Rather, early steps of neural circuit formation are likely to contribute. Many cell adhesion molecules are located at synapses but only few of them can be considered synaptic cell adhesion molecules in the strict sense. Besides the Neurexins and Neuroligins, the LRRTMs (leucine rich repeat transmembrane proteins) and the SynCAMs/CADMs can induce synapse formation when expressed in non-neuronal cells and therefore are true synaptic cell adhesion molecules. SynCAMs (synaptic cell adhesion molecules) are a subfamily of the immunoglobulin superfamily of cell adhesion molecules. As suggested by their name, they were first identified as cell adhesion molecules at the synapse which were sufficient to trigger synapse formation. They also contribute to myelination by mediating axon-glia cell contacts. More recently, their role in earlier stages of neural circuit formation was demonstrated, as they also guide axons both in the peripheral and in the central nervous system. Mutations in SynCAM genes were found in patients diagnosed with autism spectrum disorders. The diverse functions of SynCAMs during development suggest that neurodevelopmental disorders are not only due to defects in synaptic plasticity. Rather, early steps of neural circuit formation are likely to contribute.

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Disruption ofNectin-Like 1Cell Adhesion Molecule Leads to Delayed Axonal Myelination in the CNS

Cited by 60 publications

References 22 publications

Nectin-like molecules/SynCAMs are required for post-crossing commissural axon guidance

Nectin-like molecules/SynCAMs are required for post-crossing commissural axon guidance

The Expression of TAG-1 in Glial Cells Is Sufficient for the Formation of the Juxtaparanodal Complex and the Phenotypic Rescue of Tag-1 Homozygous Mutants in the CNS

SynCAMs – From axon guidance to neurodevelopmental disorders

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