Disruption of cigarette smoking addiction after posterior cingulate damage

Jarraya, Béchir; Brugières, Pierre; Tani, Naoki; Hodel, Jérôme; Grandjacques, Bénédicte; Fénelon, Gilles; Decq, Philippe; Palfi, Stéphane

doi:10.3171/2010.6.jns10346

Cited by 30 publications

(22 citation statements)

References 12 publications

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“…Prior work has linked increased posterior cingulate activation with increased craving (Franklin et al, 2007), suggesting that this region is sensitive to disruption by nicotine. In fact, one case study suggested that a lesion to posterior cingulate disrupted nicotine addiction altogether (Jarraya et al, 2010). In oculomotor studies, posterior cingulate, similar to anterior cingulate, has been noted to contribute to active saccadic inhibition (Brown et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Abstinent adult daily smokers show reduced anticipatory but elevated saccade-related brain responses during a rewarded antisaccade task

Geier

Sweitzer

Denlinger

et al. 2014

Psychiatry Research: Neuroimaging

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Chronic smoking may result in reduced sensitivity to non-drug rewards (e.g., money), a phenomenon particularly salient during abstinence. During a quit attempt, this effect may contribute to biased decision-making (smoking > alternative reinforcers) and relapse. Although relevant for quitting, characterization of reduced reward function in abstinent smokers remains limited. Moreover, how attenuated reward function affects other brain systems supporting decision-making has not been established. Here, we use a rewarded antisaccade (rAS) task to characterize non-drug reward processing and its influence on inhibitory control, key elements underlying decision-making, in abstinent smokers vs. non-smokers. Abstinent (12-hours) adult daily smokers (N=23) and non-smokers (N=11) underwent fMRI while performing the rAS. Behavioral performances improved on reward vs. neutral trials. Smokers showed attenuated activation in ventral striatum during the reward cue and in superior precentral sulcus and posterior parietal cortex during response preparation, but greater responses during the saccade response in posterior cingulate and parietal cortices. Smokers' attenuated anticipatory responses suggest reduced motivation from monetary reward, while heightened activation during the saccade response suggests that additional circuitry may be engaged later to enhance inhibitory task performance. Overall, this preliminary study highlights group differences in decision-making components and the utility of the rAS to characterize these effects.

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Section: Discussionmentioning

confidence: 99%

Abstinent adult daily smokers show reduced anticipatory but elevated saccade-related brain responses during a rewarded antisaccade task

Geier

Sweitzer

Denlinger

et al. 2014

Psychiatry Research: Neuroimaging

View full text Add to dashboard Cite

show abstract

“…Reduced functional connectivity between putamen and cingulate cortex was found to be correlated with nicotine addiction severity [27]. A recent case study reported that a woman with a history of an addiction to cigarette smoking reported an immediate and complete disruption of her addiction to cigarette smoking following after posterior cingulate damage [28]. This observation suggests that the posterior cingulate cortex may also play an important role in the addiction to cigarette smoking.…”

Section: Discussionmentioning

confidence: 99%

Regional Grey and White Matter Changes in Heavy Male Smokers

Zhao

Lü

2011

PLoS ONE

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Cigarette smoking is highly prevalent in the general population but the effects of chronic smoking on brain structures are still unclear. Previous studies have found mixed results regarding regional grey matter abnormalities in smokers. To characterize both grey and white matter changes in heavy male smokers, we investigated 16 heavy smokers and 16 matched healthy controls, using both univariate voxel-based morphometry (VBM) and multivariate pattern classification analysis. Compared with controls, heavy smokers exhibited smaller grey matter volume in cerebellum, as well as larger white matter volume in putamen, anterior and middle cingulate cortex. Further, the spatial patterns of grey matter or white matter both discriminated smokers from controls in these regions as well as in other brain regions. Our findings demonstrated volume abnormalities not only in the grey matter but also in the white matter in heavy male smokers. The multivariate analysis suggests that chronic smoking may be associated with volume alternations in broader brain regions than those identified in VBM analysis. These results may better our understanding of the neurobiological consequence of smoking and inform smoking treatment.

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“…These results are in line with some previous findings. For example, in one study, a stroke that produced a lesion of the PCC resulted in an immediate cessation of smoking (40). More generally, studies of addicted smokers have shown increased activity in PCC and cerebellum in comparison with those of nonsmokers (12,17,19).…”

Section: Discussionmentioning

confidence: 99%

Brief meditation training induces smoking reduction

Tang

Posner

2013

Proc. Natl. Acad. Sci. U.S.A.

173

119

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More than 5 million deaths a year are attributable to tobacco smoking, but attempts to help people either quit or reduce their smoking often fail, perhaps in part because the intention to quit activates brain networks related to craving. We recruited participants interested in general stress reduction and randomly assigned them to meditation training or a relaxation training control. Among smokers, 2 wk of meditation training (5 h in total) produced a significant reduction in smoking of 60%; no reduction was found in the relaxation control. Resting-state brain scans showed increased activity for the meditation group in the anterior cingulate and prefrontal cortex, brain areas related to self-control. These results suggest that brief meditation training improves self-control capacity and reduces smoking.addiction | anterior cingulate cortex | brain state | integrative body-mind training | mindfulness S moking harms nearly every organ of the body, causing many diseases and compromising smokers' health (1). Despite the negative consequences, many smokers have difficulty quitting or even reducing tobacco use (2). In addition, many teenagers are added to the smoking roll each year and may be at risk for abuse of other substances (2). Because tobacco use is often thought of as a gateway to other drug use, reducing smoking might reduce the vulnerability of youths to cocaine and other drugs (3). Although public health campaigns may have decreased the number of smokers, current methods for aiding those who persist in smoking have had limited success (4, 5). These failures may be a result of the inability to relieve withdrawal symptoms, stress, and cue-induced cravings, which often leads to drug seeking and taking (6-10). This urgent need calls for a short-term, effective intervention for reducing smoking behavior and cravings (2).One reason for addiction to tobacco may involve a deficit in selfcontrol. Self-control is important because the level of childhood self-control predicts long-term outcomes, including mental health, substance abuse, financial independence, and criminal behavior (11). Individuals at risk for substance abuse typically have deficits in self-control (12-16). Dysfunction of the prefrontal cortex (PFC), including dorsolateral PFC, anterior cingulate cortex (ACC), and medial orbitofrontal cortex, play a key role in addiction (12,17,18). In cigarette smokers, regional cerebral blood flow was reduced in the left dorsal ACC, and this correlated with a decrease in craving after smoking the first cigarette of the day (19). These reports raise the question of whether impaired self-control could be ameliorated and strengthened with intervention, and thus potentially change smoking behavior.There is emerging evidence that mindfulness meditation has the potential to ameliorate negative outcomes resulting from deficits in self-control (20-25). Although preliminary findings suggest mindfulness training shows some proof of efficacy in substance abuse, these studies are replete with limitations, including a lack of ...

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Disruption of cigarette smoking addiction after posterior cingulate damage

Cited by 30 publications

References 12 publications

Abstinent adult daily smokers show reduced anticipatory but elevated saccade-related brain responses during a rewarded antisaccade task

Abstinent adult daily smokers show reduced anticipatory but elevated saccade-related brain responses during a rewarded antisaccade task

Regional Grey and White Matter Changes in Heavy Male Smokers

Brief meditation training induces smoking reduction

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