Disruption of autism-associatedPcdh9gene leads to transcriptional alterations, synapses overgrowth and aberrant excitatory transmission in the CA1
Federico Miozzo,
Luca Murru,
Greta Maiellano
et al.
Abstract:Protocadherins are cell adhesion molecules with crucial role in cell-cell contacts, whose mutations or altered expression have been implicated in multiple brain disorders. In particular, growing evidence links genetic alterations in Protocadherin 9 (PCDH9) gene with Autism Spectrum Disorder (ASD) and Major Depression Disorder (MDD). Furthermore, Pcdh9 deletion induces neuronal defects in the mouse somatosensory cortex, accompanied by sensorimotor and memory impairment. However, the synaptic and molecular mecha… Show more
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