Disrupting CISD2 function in cancer cells primarily impacts mitochondrial labile iron levels and triggers TXNIP expression

Sohn, Yang-Sung; Zandalinas, Sara I.; Rowland, Linda M.; King, Skylar D.; Nechushtai, Rachel; Mittler, Ron

doi:10.1016/j.freeradbiomed.2021.09.013

Cited by 27 publications

(34 citation statements)

References 75 publications

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“…The TXNIP-TRX-TrxR redox pathway may be involved in retinal pigment epithelium dysfunction of DR and other neurodegenerative diseases [ 97 ]. Moreover, studies have shown that interfering with the function of CISD 2 protein in human breast cancer cells can enhance the expression of tumor suppressor TXNIP, which is related to the activation of ferroptosis [ 98 ].…”

Section: Ferroptosis and Ferritinophagy Participate In The Pathogenes...mentioning

confidence: 99%

Ferroptosis and ferritinophagy in diabetes complications

Xia

et al. 2022

Molecular Metabolism

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Section: Ferroptosis and Ferritinophagy Participate In The Pathogenes...mentioning

confidence: 99%

Ferroptosis and ferritinophagy in diabetes complications

Xia

et al. 2022

Molecular Metabolism

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“…In addition, genes involved in iron pool regulation also act as powerful prognostic indicators for CRC. Accumulation of mitochondrial labile iron is associated with enhanced expression of the tumor suppressor thioredoxin-interacting protein (TXNIP) [95]. Cysteine desulfurase (NFS1) activity is important for maintaining the iron-sulfur co-factors, the suppressing of which could predispose cells to ferroptosis [96].…”

Section: The Role Of Ferroptosis In Colorectal Cancer (Crc)mentioning

confidence: 99%

Ferroptosis: A Double-Edged Sword in Gastrointestinal Disease

Liu

Xiao

2021

IJMS

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Ferroptosis is a novel form of regulated cell death (RCD) that is typically accompanied by iron accumulation and lipid peroxidation. In contrast to apoptosis, autophagy, and necroptosis, ferroptosis has unique biological processes and pathophysiological characteristics. Since it was first proposed in 2012, ferroptosis has attracted attention worldwide. Ferroptosis is involved in the progression of multiple diseases and could be a novel therapeutic target in the future. Recently, tremendous progress has been made regarding ferroptosis and gastrointestinal diseases, including intestinal ischemia/reperfusion (I/R) injury, inflammatory bowel disease (IBD), gastric cancer (GC), and colorectal cancer (CRC). In this review, we summarize the recent progress on ferroptosis and its interaction with gastrointestinal diseases. Understanding the role of ferroptosis in gastrointestinal disease pathogenesis could provide novel therapeutic targets for clinical treatment.

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“…Proteomics analysis was conducted on heart tissues (left ventricle) obtained from six different animals (three different males and three different females) from each group (Control, CISD2-KO and Old mice). Tissues were subjected to protein extraction using 175 mM Tris-HCl pH 6.8, 5% SDS, 100 mM DTT, as described in Refs [46,47]. Tissues were homogenized by using a Fisher Scientific 150 hand-held homogenizer using disposable plastic probes and further heated at 65 °C for 20 min.…”

Section: Proteomics Analysismentioning

confidence: 99%

The [2Fe‐2S] protein CISD2 plays a key role in preventing iron accumulation in cardiomyocytes

et al. 2022

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Considered a key aging gene, CISD2, encoding CDGSH iron-sulfur domaincontaining protein 2, plays a central role in regulating calcium homeostasis, preventing mitochondrial dysfunction, and the activation of autophagy and apoptosis in different cells. Here, we show that cardiomyocytes from CISD2null mice accumulate high levels of iron and contain high levels of transferrin receptor and ferritin. Using proteomics and transmission electron microscopy, we further show that the lack of CISD2 induces several features of the aging process in young mice, but other features are not induced. Taken together, our findings suggest that CISD2 protects cardiomyocytes from overaccumulation of iron, which is common in aging hearts and can contribute to the pathogenesis of heart failure.

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Disrupting CISD2 function in cancer cells primarily impacts mitochondrial labile iron levels and triggers TXNIP expression

Cited by 27 publications

References 75 publications

Ferroptosis and ferritinophagy in diabetes complications

Ferroptosis and ferritinophagy in diabetes complications

Ferroptosis: A Double-Edged Sword in Gastrointestinal Disease

The [2Fe‐2S] protein CISD2 plays a key role in preventing iron accumulation in cardiomyocytes

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