Disrupted Topological Organization of Resting‐State Functional Brain Network in Subcortical Vascular Mild Cognitive Impairment

Yi, Liye; Liang, Xia; Liu, Daming; Sun, Bo; Sun, Ying; Yang, Dan; Li, Qingbin; Jiang, Chuanlu; Han, Ying

doi:10.1111/cns.12424

Cited by 42 publications

(42 citation statements)

References 77 publications

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“…Previous studies have demonstrated that a disrupted topological organization of nodes is strongly correlated with CI or dementia, but the potential mechanisms are still unclear (Wen et al, 2005;Tuladhar et al, 2015;Yi et al, 2015). Here, we conduct a mediation analysis to further investigate the effect of nodal efficiency on the positive correlation between WMH burden and CI.…”

Section: Mediation Of the Association Between Pwmh And Information Prmentioning

confidence: 93%

Nodal Global Efficiency in Front-Parietal Lobe Mediated Periventricular White Matter Hyperintensity (PWMH)-Related Cognitive Impairment

Chen

Huang

Yang

et al. 2019

Front. Aging Neurosci.

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White matter hyperintensity (WMH) is widely observed in the elderly population and serves as a key indicator of cognitive impairment (CI). However, the underlying mechanism remains to be elucidated. Herein, we investigated the topological patterns of resting state functional networks in WMH subjects and the relationship between the topological measures and CI. A graph theory-based analysis was employed in the resting-state functional magnetic resonance scans of 112 subjects (38 WMH subjects with cognitive impairment without dementia (CIND), 36 WMH subjects with normal cognition and 38 healthy controls (HCs), and we found that WMH-CIND subjects displayed decreased global efficiency at the levels of the whole brain, specific subnetworks [fronto-parietal network (FPN) and cingulo-opercular network (CON)] and certain nodes located in the FPN and CON, as well as decreased local efficiency in subnetworks. Our results demonstrated that nodal global efficiency in frontal and parietal regions mediated the impairment of information processing speed related to periventricular WMH (PWMH). Additionally, we performed support vector machine (SVM) analysis and found that altered functional efficiency can identify WMH-CIND subjects with high accuracy, sensitivity and specificity. These findings suggest impaired functional networks in WMH-CIND individuals and that decreased functional efficiency may be a feature of CI in WMH subjects.

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Section: Mediation Of the Association Between Pwmh And Information Prmentioning

confidence: 93%

Nodal Global Efficiency in Front-Parietal Lobe Mediated Periventricular White Matter Hyperintensity (PWMH)-Related Cognitive Impairment

Chen

Huang

Yang

et al. 2019

Front. Aging Neurosci.

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“…Similarly, individuals with greater negative correlation between default mode and working memory networks exhibited better behavioural performance on a working memory task (Sala-Llonch et al, 2012). Conversely, in subcortical vascular mild cognitive impairment, increased integration between modules in the inferior and superior parietal gyrus at rest has been shown to be associated with impaired cognitive performance (Yi et al, 2015). Finally, such a broad competitive process is supported by recent work in normative neurodevelopment showing that individuals with weaker sensorimotor integration at rest tended to display better cognitive performance (N = 780 in the Philadelphia Neurodevelopmental Cohort) (Gu et al, 2015).…”

Section: The Benefits Of Independencementioning

confidence: 99%

Predicting future learning from baseline network architecture

Mattar

Wymbs

Bock

et al. 2016

Preprint

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Human behavior and cognition result from a complex pattern of interactions between brain regions. The flexible reconfiguration of these patterns enables behavioral adaptation, such as the acquisition of a new motor skill. Yet, the degree to which these reconfigurations depend on the brain's baseline sensorimotor integration is far from understood. Here, we asked whether spontaneous fluctuations in sensorimotor networks at baseline were predictive of individual differences in future learning. We analyzed functional MRI data from 19 participants prior to six weeks of training on a new motor skill. We found that visual-motor connectivity was inversely related to learning rate: sensorimotor autonomy at baseline corresponded to faster learning in the future. Using three additional scans, we found that visual-motor connectivity at baseline is a stable individual trait. These results that individual differences in motor skill learning can be predicted from sensorimotor autonomy at baseline prior to task execution.

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“…Both structural and functional connectivity contribute independently to healthy cognitive aging (Liem et al, 2017). In older adults with small vessel ischemic disease, worse cognitive control is associated with diminished resting state functional connectivity (RSFC) in the frontoparietal network, default mode network (DMN), and in subcortical structures (Schaefer et al, 2014;Sun et al, 2011;Yi et al, 2015). Despite advances in neuroimaging techniques, the interrelationships among neuroimaging markers of cerebrovascular disease (WMH), structural connectivity, and RSFC, and how these interactions may contribute to age-related changes in cognitive control, is largely unknown.…”

Section: Introductionmentioning

confidence: 99%

Estimated regional white matter hyperintensity burden, resting state functional connectivity, and cognitive functions in older adults

Jaywant

Dunlop

Victoria

et al. 2020

Preprint

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White matter hyperintensities (WMH) are linked to cognitive control; however, the structural and functional mechanisms are largely unknown. We investigated the relationship between WMH-associated disruptions of structural connectivity, resting state functional connectivity (RSFC), and cognitive control in older adults. Fifty-eight cognitively-healthy older adults completed cognitive control tasks, structural MRI, and resting state fMRI scans. We estimated inferred, WMH-related disruptions in structural connectivity between pairs of subcortical and cortical regions by overlaying each participant's WMH mask on a normative tractogram dataset.For region-pairs in which structural disconnection was associated with cognitive control, we calculated RSFC between nodes in those same regions. WMH-related structural disconnection and RSFC in the cognitive control network and default mode network were both associated with poorer cognitive inhibition. These regionally-specific, WMH-related structural and functional changes were more strongly associated with cognitive inhibition compared to standard rating of WMH burden. Our findings highlight the role of circuit-level disruptions to the cognitive control network and default mode network that are related to WMH and impact cognitive control in aging.

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Disrupted Topological Organization of Resting‐State Functional Brain Network in Subcortical Vascular Mild Cognitive Impairment

Abstract: Together, our results indicate that svMCI patients exhibit dysregulation of the topological organization of functional brain networks, which has important implications for understanding the pathophysiological mechanism of svMCI.

Cited by 42 publications

References 77 publications

Nodal Global Efficiency in Front-Parietal Lobe Mediated Periventricular White Matter Hyperintensity (PWMH)-Related Cognitive Impairment

Nodal Global Efficiency in Front-Parietal Lobe Mediated Periventricular White Matter Hyperintensity (PWMH)-Related Cognitive Impairment

Predicting future learning from baseline network architecture

Estimated regional white matter hyperintensity burden, resting state functional connectivity, and cognitive functions in older adults

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