Disrupted small-world brain network in children with Down Syndrome

Ahmadlou, Mehran; Gharib, Masoud; Hemmati, Sahel; Vameghi, Roshanak; Sajedi, Firoozeh

doi:10.1016/j.clinph.2013.03.004

Cited by 13 publications

(33 citation statements)

References 87 publications

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“…Cognitive improvement due better executive function received. Moreover, past researches were showed in Cerebral palsy, relation between the deficient brain dynamics and severity of disabilities [19] and trying on Delta and Alfa brain waves are showing improvement in them [20]. Consistent with our prediction, the children with ASD made larger improvement in this area after Neurofeedback training.…”

Section: Discussionsupporting

confidence: 77%

The Effect of Neurofeedback on Brain Waves in Children With Autism Spectrum Disorders

Hemmati

Vameghi

Sajedi

et al. 2016

IRJ

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Objectives: Autism Spectrum Disorder (ASD) is a group of neurodevelopment syndromes with impairments in social communications and restrictive or repetitive behaviors. Neurofeedback is a new method that may regulate neuro and metabolic function in brain. This study is semiexperimental, with pre and post test. Methods:In 26 children with ASD, 40 sessions of Neurofeedback were done. Brain waves were recorded before and after intervention by EEG/ERP 19 channels. Results:The average of Theta (low frequency) power decreased, but there was no difference in the Gamma of Gamma waves (High frequency).Discussion: Our findings showed that the implementation of Neurofeedback sessions improved Theta, which leads to better social communication.

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Section: Discussionsupporting

confidence: 77%

The Effect of Neurofeedback on Brain Waves in Children With Autism Spectrum Disorders

Hemmati

Vameghi

Sajedi

et al. 2016

IRJ

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“…Anderson et al used connectivity indexes to characterize brain connectivity architecture and identified an anomalous general synchrony with a simplified network structure. A recent study in Down syndrome assessing synchrony on EEG frequency bands reached similar conclusions (Ahmadlou et al, 2013). In contrast to the previous global assessments, our approach permitted to map system-specific functional connectivity alterations in brain structures with pronounced developmental disturbances.…”

Section: Discussionmentioning

confidence: 51%

“…The subset of strong connections, however, distinctively showed the most severe effects that involved both connectivity increases and decreases. Other graph connectivity approaches using near-infrared spectroscopy (Imai et al, 2014) and EEG-based small-world metrics (Ahmadlou, Gharib, Hemmati, Vameghi, & Sajedi, 2013) also suggested that the global changes may combine with specific connectivity anomalies, although the neural systems implicated were not identified.…”

Section: Introductionmentioning

confidence: 97%

Anomalous brain functional connectivity contributing to poor adaptive behavior in Down syndrome

Pujol

Hoyo

Blanco‐Hinojo

et al. 2015

Cortex

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“…While this notion makes it challenging to discuss the ultimate significance of these results, emerging literature does cite the utility of this method for investigating cognition [49] as well functional network changes in brain disorders [50], with correlative remarks to enable our discussion of this method incontext.…”

Section: Functional Connectivity Analysismentioning

confidence: 99%

Cortical recruitment and functional dynamics in postural control adaptation and habituation during vibratory proprioceptive stimulation

Edmunds¹,

Petersen²,

Hassan³

et al. 2019

J. Neural Eng.

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Objective. Maintaining upright posture is a complex task governed by the integration of afferent sensorimotor and visual information with compensatory neuromuscular reactions. The objective of the present work was to characterize the visual dependency and functional dynamics of cortical activation during postural control.Approach. Proprioceptic vibratory stimulation of calf muscles at 85 Hz was performed to evoke postural perturbation in open-eye (OE) and closed-eye (CE) experimental trials, with pseudorandom binary stimulation phases divided into four segments of 16 stimuli. 64-channel EEG was recorded at 512 Hz, with perturbation epochs defined using bipolar electrodes placed proximal to each vibrator. Power spectra variation and linearity analysis was performed via fast Fourier transformation into six frequency bands (Δ, θ, α, β, γ_low, and γ_high,. Finally, functional connectivity assessment was explored via network segregation and integration analyses.Main Results. Spectra variation showed waveform and vision-dependent activation within cortical regions specific to both postural adaptation and habituation. Generalized spectral variation yielded significant shifts from low to high frequencies in CE adaptation trials, with overall activity suppressed in habituation; OE trials showed the opposite phenomenon, with both adaptation and habituation yielding increases in spectral power. Finally, our analysis of functional dynamics reveals novel cortical networks implicated in postural control using EEG source-space brain networks. In particular, our reported significant increase in local θ connectivity may signify the planning of corrective steps and/or the analysis of falling consequences, while α band network integration results reflect an inhibition of error detection within the cingulate cortex, likely due to habituation.Significance. Our findings principally suggest that specific cortical waveforms are dependent upon the availability of visual feedback, and we furthermore present the first evidence that local and global brain networks undergo characteristic modification during postural control.

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Disrupted small-world brain network in children with Down Syndrome

Cited by 13 publications

References 87 publications

The Effect of Neurofeedback on Brain Waves in Children With Autism Spectrum Disorders

The Effect of Neurofeedback on Brain Waves in Children With Autism Spectrum Disorders

Anomalous brain functional connectivity contributing to poor adaptive behavior in Down syndrome

Cortical recruitment and functional dynamics in postural control adaptation and habituation during vibratory proprioceptive stimulation

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