Disrupted resting-state functional connectivity of the thalamus in patients with coronary heart disease

Wei, Hong; Ao, Ming-Qiang; Wang, Mengyao; Zhou, Gang-Ping; Yu, Yu-Sheng; Qin, Tao; Zhang, Hong

doi:10.1016/j.heliyon.2023.e13423

Cited by 3 publications

(4 citation statements)

References 38 publications

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“…This cell-type enrichment signature was not found for MDD or ASCVD alone, suggesting that a distinct mechanism involving thalamic circuits might underlie the shared liability to MDD-ASCVD. Altered thalamic function has indeed been implicated previously in CVD [51][52][53] and MDD 54,55 , and white matter integrity in thalamic radiations show associations with aortic area and myocardial wall thickness, suggesting that it has a role in the 'heart-brain' connection 56 .…”

Section: Discussionmentioning

confidence: 76%

Distinct biological signature and modifiable risk factors underlie the comorbidity between major depressive disorder and cardiovascular disease

Bergstedt,

Pasman,

et al. 2024

Nat Cardiovasc Res

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Major depressive disorder (MDD) and cardiovascular disease (CVD) are often comorbid, resulting in excess morbidity and mortality. Here we show that CVDs share most of their genetic risk factors with MDD. Multivariate genome-wide association analysis of shared genetic liability between MDD and atherosclerotic CVD revealed seven loci and distinct patterns of tissue and brain cell-type enrichments, suggesting the involvement of the thalamus. Part of the genetic overlap was explained by shared inflammatory, metabolic and psychosocial or lifestyle risk factors. Our data indicated causal effects of genetic liability to MDD on CVD risk, but not from most CVDs to MDD, and showed that the causal effects were partly explained by metabolic and psychosocial or lifestyle factors. The distinct signature of MDD–atherosclerotic CVD comorbidity suggests an immunometabolic subtype of MDD that is more strongly associated with CVD than overall MDD. In summary, we identified biological mechanisms underlying MDD–CVD comorbidity and modifiable risk factors for prevention of CVD in individuals with MDD.

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Section: Discussionmentioning

confidence: 76%

Distinct biological signature and modifiable risk factors underlie the comorbidity between major depressive disorder and cardiovascular disease

Bergstedt,

Pasman,

et al. 2024

Nat Cardiovasc Res

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“…This cell-type enrichment signature was not found for MDD or CVD alone, suggesting that a distinct biological mechanism involving thalamic circuits underlies the shared liability to MDD-CVD. Altered thalamic function has indeed been implicated previously in CVD [32][33][34] and MDD 35,36 , and white matter integrity in thalamic radiations show associations with aortic area and myocardial wall thickness, suggesting that it has a role in the 'heart-brain' connection 37 .…”

Section: Discussionmentioning

confidence: 76%

Distinct genomic signatures and modifiable risk factors underly the comorbidity between major depressive disorder and cardiovascular disease

Bergstedt,

Pasman,

et al. 2023

Preprint

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Major depressive disorder (MDD) and cardiovascular disease (CVD) are often comorbid, resulting in excess morbidity and mortality. Using genetic data, this study elucidates biological mechanisms, key risk factors, and causal pathways underlying the comorbidity. We show that CVDs share a large proportion of their genetic risk factors with MDD. Multivariate genome-wide association analysis of the shared genetic liability between MDD and CVD revealed seven novel loci and distinct patterns of tissue and brain cell-type enrichments, suggesting a role for the thalamus. Part of the genetic overlap was explained by shared inflammatory, metabolic, and psychosocial risk factors. Finally, we found support for causal effects of genetic liability to MDD on CVD risk, but not vice versa, and demonstrated that the causal effects are partly explained by metabolic and psychosocial factors. The distinct signature of MDD-CVD comorbidity aligns with the idea of an immunometabolic sub-type of MDD more strongly associated with CVD than overall MDD. In summary, we identify plausible biological mechanisms underlying MDD-CVD comorbidity, as well as key modifiable risk factors for prevention of CVD in individuals with MDD.

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“…Resting State fMRI Among the 9 studies, 4 of them performed resting-state fMRI, whereof, 2 studies [7,22] reported sensorimotor networks (SMN), and another study [17] reported the default mode network (DMN). Wei and colleagues (2023) investigated the thalamus-based functional connectivity (FC) patterns in patients with CHD.…”

Section: Functional Mri Outcomesmentioning

confidence: 99%

“…Data has shown a signi cant link between CHD and structural and functional alterations in the central nervous system (CNS) [6]. In fact, clinical evidence indicates a strong connection between cardiac malfunction and cerebral injury [7]. Heart failure (HF), which is a rapidly growing phenomenon in the Western world, is most likely attributable to the existence of CHDs.…”

Section: Introductionmentioning

confidence: 99%

Effect of cardiovascular diseases on brain functional changes and cognition: a systematic review of fMRI studies

Humayra,

Yahya,

Ning

et al. 2024

Preprint

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Background Functional magnetic resonance imaging (fMRI) is a useful tool to evaluate brain inefficiencies secondary to cardiovascular diseases (CVDs); nevertheless, limited fMRI studies have been conducted to investigate the effect of CVD on brain functional changes and cognition. This systematic review aims to explore, synthesise, and report the fMRI outcomes and cognitive changes in patients with CVDs. Methods Two reviewers independently searched published literature until August 2023 on ScienceDirect, PubMed, Web of Science, and ClinicalTrials.gov. A total of 22 eligible studies were considered for full-text screening, of which 9 were included in this review. The methodological quality was assessed by mixed methods appraisal tool and reported as empirically fair. Results Among the 312 CVD subjects, aged between 49.90 ± 6.10 to 72.20 ± 5.70 years, majority had coronary heart diseases (n = 153, 40.04%) and hypertension (n = 188, 60.26%), and approximately half of them were females (n = 157, 50.32%). Based on the qualitative synthesis, CVD subjects have increased cognitive decline and poorer task performance (reduced Mini-Mental State Examination/Montreal Cognitive Assessment, lower mean 2-back task scores, and slower reaction time). Results also indicate impaired brain activity at supplementary motor area associated with poor ejection fraction, and reduced default mode network suppression linked to high low-density lipoprotein cholesterol; lower regional homogeneity and amplitude of low-frequency fluctuation values; and reduced functional connectivity. Conclusion It can be extrapolated that CVDs tend to alter brain network connectivity and result in cognitive impairment. However, for future imaging studies, more stringent and homogenous demographic data are highly recommended.

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Disrupted resting-state functional connectivity of the thalamus in patients with coronary heart disease

Cited by 3 publications

References 38 publications

Distinct biological signature and modifiable risk factors underlie the comorbidity between major depressive disorder and cardiovascular disease

Distinct biological signature and modifiable risk factors underlie the comorbidity between major depressive disorder and cardiovascular disease

Distinct genomic signatures and modifiable risk factors underly the comorbidity between major depressive disorder and cardiovascular disease

Effect of cardiovascular diseases on brain functional changes and cognition: a systematic review of fMRI studies

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