Disrupted Resting-State Functional Connectivity in Progressive Supranuclear Palsy

Piattella, Maria Cristina; Tona, Francesca; Bologna, Matteo; Sbardella, Emilia; Formica, Alessandro; Petsas, Nikolaos; Filippini, Nicola; Berardelli, Alfredo; Pantano, P.

doi:10.3174/ajnr.a4229

Cited by 32 publications

(24 citation statements)

References 44 publications

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“…We used an unbiased approach of whole-brain rsFC analysis that provides an overall view of spontaneous brain activity at rest, which is arranged in clearly defined functional networks (14). Previous rsFC investigations on PSP, which, unlike ours, used an a priori -based approach, reported reduced rsFC of pre-defined regions of interest, i.e., between subcortical nuclei and cortical and cerebellar areas (10–12). Results obtained by means of different fMRI postprocessing methodologies and including heterogeneous samples of patients cannot, however, easily be compared.…”

Section: Discussionmentioning

confidence: 56%

“…The temporal correlation of these BOLD signal fluctuations across various brain regions may reflect a resting-state functional connectivity (rsFC) between them, i.e., the presence of resting-state network (RSN) (9). Few rsfMRI studies on PSP patients adopted a seed-based analysis, which requires an a priori hypothesis, and showed disrupted rsFC in several subcortical nuclei (10–12). By contrast, only one study on CBS patients showed rsFC changes in the sensorimotor network that was associated with motor and cognitive abnormalities (13).…”

Section: Introductionmentioning

confidence: 99%

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Abnormal Resting-State Functional Connectivity in Progressive Supranuclear Palsy and Corticobasal Syndrome

et al. 2017

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BackgroundPathological and MRI-based evidence suggests that multiple brain structures are likely to be involved in functional disconnection between brain areas. Few studies have investigated resting-state functional connectivity (rsFC) in progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS). In this study, we investigated within- and between-network rsFC abnormalities in these two conditions.MethodsTwenty patients with PSP, 11 patients with CBS, and 16 healthy subjects (HS) underwent a resting-state fMRI study. Resting-state networks (RSNs) were extracted to evaluate within- and between-network rsFC using the Melodic and FSLNets software packages.ResultsIncreased within-network rsFC was observed in both PSP and CBS patients, with a larger number of RSNs being involved in CBS. Within-network cerebellar rsFC positively correlated with mini-mental state examination scores in patients with PSP. Compared to healthy volunteers, PSP and CBS patients exhibit reduced functional connectivity between the lateral visual and auditory RSNs, with PSP patients additionally showing lower functional connectivity between the cerebellar and insular RSNs. Moreover, rsFC between the salience and executive-control RSNs was increased in patients with CBS compared to HS.ConclusionThis study provides evidence of functional brain reorganization in both PSP and CBS. Increased within-network rsFC could represent a higher degree of synchronization in damaged brain areas, while between-network rsFC abnormalities may mainly reflect degeneration of long-range white matter fibers.

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Section: Discussionmentioning

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Abnormal Resting-State Functional Connectivity in Progressive Supranuclear Palsy and Corticobasal Syndrome

et al. 2017

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“…Alexithymia in PSP‐RS is apparently linked to depression, as depressed PSP‐RS subjects showed a significantly higher score at TAS‐20 and TAS‐20 F2 than PD subjects (Table ). Based on these findings, we speculate that the greater impairment of affective abilities in PSP as compared to PD patients may be related to the distinct pattern of frontal lobe and subcortical structures atrophy in the former (Brenneis et al, ; Piattella et al, ; Williams & Lees, ). In fact, prefrontal, limbic, and striatal abnormalities may contribute significantly to the derangement of effortful emotional regulatory processes and emotional processing (Assogna et al, , ; Eack et al, ; Worker et al, ).…”

Section: Discussionmentioning

confidence: 84%

Alexithymia and anhedonia in early Richardson's syndrome and progressive supranuclear palsy with predominant parkinsonism

Assogna

Pellicano

Cravello³

et al. 2019

Brain and Behavior

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IntroductionPhenotypic variants of progressive supranuclear palsy (PSP) are all characterized by the combination of motor symptoms of parkinsonism with a number of neuropsychiatric and cognitive disorders. Despite the strong effort in characterizing these features in PSP, alexithymia and anhedonia have not been investigated at present. Here, we aimed at investigating the qualitative and quantitative differences of alexithymia and anhedonia in the two more frequent variants of PSP, Richardson's syndrome (PSP‐RS) and PSP with predominant parkinsonism (PSP‐P) compared to Parkinson's disease (PD) patients recruited within 24 months after the onset of motor symptoms.MethodsOne hundred fifty‐five PD, 11 PSP‐P, and 14 PSP‐RS patients underwent clinical, neuropsychiatric, and neuropsychological evaluations. Alexithymia was assessed using the Toronto Alexithymia Scale‐20 item (TAS‐20), and hedonic tone was measured by the Snaith–Hamilton Pleasure Scale (SHAPS).ResultsIn PSP‐P and PSP‐RS patients, the frequency of alexithymia diagnosis was higher than in PD. On the TAS‐20 scores, PSP‐RS performed worse in the total score and in F2 sub‐scale when compared to PD. Among patients with diagnosis of depression, PSP‐RS showed higher scores in TAS‐20 total and TAS‐20 F2 than PD. No significant differences in TAS‐20 scores were found in nondepressed patients. Finally, we did not find significant differences among PD, PSP‐P, and PSP‐RS groups in the SHAPS scores.ConclusionsAlexithymia is identifiable very early in PSP‐P and PSP‐RS patients. Alexithymic symptoms differentiate PSP‐RS group from PD group but not between the two subtypes of PSP. Further, alexithymia in PSP seems to be predicted by the presence of depression. Altered emotional capability could be related to specific neurophysiological dysfunction occurring precociously in PSP; therefore, its identification could orient the diagnosis toward PSP cases.

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“…Like in other neurodegenerative disease syndromes, the atrophy pattern of PSPs resembles a specific large‐scale cortical‐subcortical system that has been mapped in healthy brain with RS fMRI . PSPs patients showed functionally relevant connectivity reductions within such a network, including brainstem, cerebellar, diencephalic, basal ganglia, and cortical regions involved in skeletomotor, oculomotor, and executive control (Fig ) . Patients with more severe functional impairment showed lower mean network connectivity scores …”

Section: Introductionmentioning

confidence: 87%

Charting Frontotemporal Dementia: From Genes to Networks

Filippi

Ferraro

2015

Journal of Neuroimaging

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Frontotemporal dementia (FTD) is a genetically and clinically heterogeneous syndrome that is characterized by overlapping clinical symptoms involving behavior, personality, language and/or motor functions and degeneration of the frontal and temporal lobes. The term frontotemporal lobar degeneration (FTLD) is used to describe the proteinopathies associated with clinical FTD. Emerging evidence from network-based neuroimaging studies, such as resting state functional MRI and diffusion tensor MRI studies, have implicated specific large-scale brain networks in the pathogenesis of FTD syndromes, suggesting a new paradigm for explaining the distributed and heterogeneous spreading patterns of pathological proteins in FTLD. In this review, we overview recent research on the study of FTD syndromes as connectivity disorders in symptomatic patients as well as genotype-specific changes in asymptomatic FTD-related gene mutation carriers. Characterizing brain network breakdown in these subjects using neuroimaging may help anticipate the diagnosis and perhaps prevent the devastating impact of FTD.

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Disrupted Resting-State Functional Connectivity in Progressive Supranuclear Palsy

Cited by 32 publications

References 44 publications

Abnormal Resting-State Functional Connectivity in Progressive Supranuclear Palsy and Corticobasal Syndrome

Abnormal Resting-State Functional Connectivity in Progressive Supranuclear Palsy and Corticobasal Syndrome

Alexithymia and anhedonia in early Richardson's syndrome and progressive supranuclear palsy with predominant parkinsonism

Charting Frontotemporal Dementia: From Genes to Networks

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