Disrupted resting-state functional connectivity in minimally treated chronic schizophrenia

Wang, Xijin; Xia, Mingrui; Lai, Yunyao; Dai, Zhengjia; Cao, Qingjiu; Cheng, Zhang; Han, Xue; Yang, Lei; Yuan, Yanbo; Zhang, Yong; Li, Keqing; Ma, Hong; Shi, Chuan; Hong, Nan; Szeszko, Philip R.; Yu, Xinguang; He, Yong

doi:10.1016/j.schres.2014.03.033

Cited by 84 publications

(74 citation statements)

References 58 publications

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“…He et al, (2012) reported that rs-fMRI abnormalities within the bilateral orbital frontal cortex were associated with cognitive processing speed in schizophrenia patients. These findings converge with prior work indicating that abnormal rs-fMRI connectivity was associated with worse processing speed in patients with chronic schizophrenia (Argyelan et al, 2014;Wang et al, 2014).…”

Section: Introductionsupporting

confidence: 89%

Abnormal Resting State fMRI Activity Predicts Processing Speed Deficits in First-Episode Psychosis

Gallego

Robinson

Ikuta

et al. 2015

Neuropsychopharmacol

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Little is known regarding the neuropsychological significance of resting state functional magnetic resonance imaging (rs-fMRI) activity early in the course of psychosis. Moreover, no studies have used different approaches for analysis of rs-fMRI activity and examined gray matter thickness in the same cohort. In this study, 41 patients experiencing a first-episode of psychosis (including N ¼ 17 who were antipsychotic drug-naive at the time of scanning) and 41 individually age-and sex-matched healthy volunteers completed rs-fMRI and structural MRI exams and neuropsychological assessments. We computed correlation matrices for 266 regions-of-interest across the brain to assess global connectivity. In addition, independent component analysis (ICA) was used to assess group differences in the expression of rs-fMRI activity within 20 predefined publicly available templates. Patients demonstrated lower overall rs-fMRI global connectivity compared with healthy volunteers without associated group differences in gray matter thickness assessed within the same regions-of-interest used in this analysis. Similarly, ICA revealed worse rs-fMRI expression scores across all 20 networks in patients compared with healthy volunteers, with posthoc analyses revealing significant (po0.05; corrected) abnormalities within the caudate nucleus and planum temporale. Worse processing speed correlated significantly with overall lower global connectivity using the region-of-interest approach and lower expression scores within the planum temporale using ICA. Our findings implicate dysfunction in rs-fMRI activity in first-episode psychosis prior to extensive antipsychotic treatment using different analytic approaches (in the absence of concomitant gray matter structural differences) that predict processing speed.

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Section: Introductionsupporting

confidence: 89%

Abnormal Resting State fMRI Activity Predicts Processing Speed Deficits in First-Episode Psychosis

Gallego

Robinson

Ikuta

et al. 2015

Neuropsychopharmacol

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“…Decrements in oligodendroglial density (Hof et al, 2003;van den Heuvel and Fornito, 2014), increased numbers of abnormal oligodendroglia (Uranova et al, 2011;van den Heuvel and Fornito, 2014), decreased fractional anisotropy derived from diffusion tensor imaging of fiber tracts (Nakamura et al, 2005;Wang et al, 2014), and resting-state fMRI analyses (2005; Wang et al, 2014) have all indicated that schizophrenia is characterized by anatomical/functional dysconnectivity. Alterations in connectivity are ultimately thought to result in disruption of complex neuronal circuits involved in perception, cognition, and emotion.…”

Section: Introductionmentioning

confidence: 99%

Lipidomics reveals dysfunctional glycosynapses in schizophrenia and the G72/G30 transgenic mouse

Wood

Filiou

Otte

et al. 2014

Schizophrenia Research

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“…In addition, other studies also observed reduced functional connectivity strength in the insula of schizophrenia patients 18 , which may be associated with the diminished capacity of individuals to discriminate between self-generated and external information. Moreover, ACC, AI, and SMG connections are necessary for mental life, since they are involved in cognitive, affective and behavioral displays, and in controlling empathy towards people 19 .…”

Section: Discussionmentioning

confidence: 95%

Assessment of cerebral perfusional and functional connectivity in schizophrenia using magnetic resonance imaging

Oliveira

Guimarães²,

Souza³

et al. 2017

Rev Bras Fis Med

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Disrupted resting-state functional connectivity in minimally treated chronic schizophrenia

Cited by 84 publications

References 58 publications

Abnormal Resting State fMRI Activity Predicts Processing Speed Deficits in First-Episode Psychosis

Abnormal Resting State fMRI Activity Predicts Processing Speed Deficits in First-Episode Psychosis

Lipidomics reveals dysfunctional glycosynapses in schizophrenia and the G72/G30 transgenic mouse

Assessment of cerebral perfusional and functional connectivity in schizophrenia using magnetic resonance imaging

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