Disrupted progression of the intestinal microbiota with age in children with cystic fibrosis

Nielsen, Shaun; Needham, Bronwen; Leach, Steven T.; Day, Andrew S.; Jaffé, Adam; Thomas, Torsten; Ooi, Chee Y.

doi:10.1038/srep24857

Cited by 96 publications

(160 citation statements)

References 58 publications

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“…This is a common finding of studies on CF gut microbiota compared to controls [39, 40]. Indeed, it appears from studies on children with CF that this decrease in diversity occurs early in life for CF patients, with diversity decreasing with age, with CF teenagers having diversity levels similar to those seen in healthy control infants (1 year) [39]. As CF patients live longer, there will be an increased need to appreciate how this diversity decreases with age and how best to minimise this decline, to maximise patient gut microbiota diversity.…”

Section: Discussionmentioning

confidence: 78%

“…The diversity of the gut microbiota of individuals with CF was also significantly reduced compared to that of healthy controls. This is a common finding of studies on CF gut microbiota compared to controls [39, 40]. Indeed, it appears from studies on children with CF that this decrease in diversity occurs early in life for CF patients, with diversity decreasing with age, with CF teenagers having diversity levels similar to those seen in healthy control infants (1 year) [39].…”

Section: Discussionmentioning

confidence: 88%

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The altered gut microbiota in adults with cystic fibrosis

Burke¹,

Fouhy²,

Harrison³

et al. 2017

BMC Microbiol

125

156

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BackgroundCystic Fibrosis (CF) is an autosomal recessive disease that affects the function of a number of organs, principally the lungs, but also the gastrointestinal tract. The manifestations of cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction in the gastrointestinal tract, as well as frequent antibiotic exposure, undoubtedly disrupts the gut microbiota. To analyse the effects of CF and its management on the microbiome, we compared the gut microbiota of 43 individuals with CF during a period of stability, to that of 69 non-CF controls using 454-pyrosequencing of the 16S rRNA gene. The impact of clinical parameters, including antibiotic therapy, on the results was also assessed.ResultsThe CF-associated microbiome had reduced microbial diversity, an increase in Firmicutes and a reduction in Bacteroidetes compared to the non-CF controls. While the greatest number of differences in taxonomic abundances of the intestinal microbiota was observed between individuals with CF and the healthy controls, gut microbiota differences were also reported between people with CF when grouped by clinical parameters including % predicted FEV1 (measure of lung dysfunction) and the number of intravenous (IV) antibiotic courses in the previous 12 months. Notably, CF individuals presenting with severe lung dysfunction (% predicted FEV1 ≤ 40%) had significantly (p < 0.05) reduced gut microbiota diversity relative to those presenting with mild or moderate dysfunction. A significant negative correlation (−0.383, Simpson’s Diversity Index) was also observed between the number of IV antibiotic courses and gut microbiota diversity.ConclusionsThis is one of the largest single-centre studies on gut microbiota in stable adults with CF and demonstrates the significantly altered gut microbiota, including reduced microbial diversity seen in CF patients compared to healthy controls. The data show the impact that CF and it's management have on gut microbiota, presenting the opportunity to develop CF specific probiotics to minimise microbiota alterations.Electronic supplementary materialThe online version of this article (doi:10.1186/s12866-017-0968-8) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 88%

The altered gut microbiota in adults with cystic fibrosis

Burke¹,

Fouhy²,

Harrison³

et al. 2017

BMC Microbiol

125

156

View full text Add to dashboard Cite

show abstract

“…Whether these results can be extrapolated to other age ranges is unknown. While our exclusion of samples from patients experiencing PEx/antibiotic therapies resulted in a modest reduction in cohort size, we have eliminated the confounding selective pressures of systemic antibacterials 45. While we focused our results on a single sample from each individual, we have validated that an individual’s microbiome is relatively consistent 11.…”

Section: Discussionmentioning

confidence: 98%

Sputum microbiota is predictive of long-term clinical outcomes in young adults with cystic fibrosis

Acosta

Heirali

Somayaji

et al. 2018

Thorax

104

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“…A similar correlation was observed experimentally in mice; following a reduction in the number and diversity of gut microorganisms by the administration of antibiotics at 3 weeks of age, adult mice showed exacerbated experimental allergic airway inflammation upon aero-allergen exposure [8]. Similarly, for children with cystic fibrosis, which is a genetic disorder that mainly affects the lungs, there is a large difference between their gut microbiota as compared to healthy children of the same age, with diminished levels of certain bacteria in affected children [9].…”

Section: Functional Similarities Between Gut Lung and Skinmentioning

confidence: 99%

Inter-Organ Relationships among Gut, Lung and Skin beyond the Pathogenesis of Allergies: Relevance to the Zang-Fu Theory in Chinese Medicine

Leung¹,

Leong²,

Chen³

et al. 2017

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Research on allergy has recently uncovered an apparent co-occurrence of allergies in skin and the lungs, a phenomenon that has been coined "atopic march". A positive correlation has been found between gut microbiota at birth and the development of asthma and skin eczema later in life. Chinese medicine has long described a functional relationship between the large intestine and the lungs, and between the lungs and skin. In this short article, we examined the evidence in support of these inter-organ physiological/pathological relationships. In addition to the clinical observation of the relationship between the composition of gut microbiota at birth and the development of asthma later in childhood, gut microorganisms have also been shown to exert a protective effect on bacteria-induced pneumonia in experimental animals. Genetic predisposition was also found to play an important role in the coexistence of certain diseases of lung and skin. Despite the fact that the mechanism(s) underlying the connection of immune systems between two organs (such as the large intestine and the lungs) is still not clearly understood, it is the first time to correlate the relationship among gut, lung and skin based on recent clinical studies in relation to the Zang-Fu Theory in Chinese medicine. Future investigation of the gut-lung and lung-skin axes in terms of physiological/pathological relationships may help to provide a greater understanding of the pathogenesis of allergies, possibly establishing relevance to the Zang-Fu Theory in Chinese medicine.

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Disrupted progression of the intestinal microbiota with age in children with cystic fibrosis

Cited by 96 publications

References 58 publications

The altered gut microbiota in adults with cystic fibrosis

The altered gut microbiota in adults with cystic fibrosis

Sputum microbiota is predictive of long-term clinical outcomes in young adults with cystic fibrosis

Inter-Organ Relationships among Gut, Lung and Skin beyond the Pathogenesis of Allergies: Relevance to the Zang-Fu Theory in Chinese Medicine

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