Disrupted implicit motor sequence learning in schizophrenia and bipolar disorder revealed with ambidextrous Serial Reaction Time Task

Resting-State Alpha-Band Functional Connectivity Predicts Implicit Motor Adaptation in a Serial Reaction Time Task

“…What is less clear is the long-term nature of that change. Indeed, many studies use experimental designs that lack a baseline and do not assess the stability in time of the sequence knowledge: the experiment is organized such as long sequence blocks are followed by random blocks, sometimes followed again by long sequence blocks (Chrobak et al, 2017;Deroost & Soetens, 2006;Martini et al, 2013;Nissen & Bullemer, 1987;Unsworth & Engle, 2005). In these cases, if an immediate effect is consistently observed (RT difference between sequence and random blocks), the encoding of the sequence in memory is not tested, as there is no distinction between training (long sequence block with multiple repetitions) and testing (short sequence blocks with few repetitions).…”

“…In this paradigm, a repeated sequence is inserted between random blocks without the participants' knowledge. The sequence repetition is thought to induce implicit learning of the sequence, measured as the difference in response time (RT) between sequence and random trials (Chrobak et al, 2017;Deroost & Soetens, 2006;Martini et al, 2013;Nissen & Bullemer, 1987;Unsworth & Engle, 2005). In addition, offline improvement of this implicit learning during a daytime interval has been observed (Brown et al, 2009;Cohen et al, 2005;Press et al, 2005;Robertson et al, 2004b;Sami et al, 2014), suggesting that sleep is not necessary to consolidate implicitly learned motor skills.…”

A Cross-Species Systems Genetics Analysis Links APBB1IP as a Candidate for Schizophrenia and Prepulse Inhibition

“…When correlated with the phenotypes database on GN, the most significant correlation was with visual discrimination learning using a touchscreen assay, mean reaction time to nose-poke in 3-month-old males (GN 16210, rho = −0.8137, p = 2.06e-05, N = 17). This is of interest, as reaction time is known to be disrupted in schizophrenia patients and their relatives (Chrobak et al, 2017).…”

Relationship between neurological and cerebellar soft signs, and implicit motor learning in schizophrenia and bipolar disorder

“…Growing number of studies point toward implicit motor deficits in SZ and BD (Chrobak et al, 2017(Chrobak et al, , 2015. Implicit motor learning relies on improving a sequence of motor acts through their repetition without conscious awareness of the exposure to the task.…”