Disrupted homeostasis of synovial hyaluronic acid and its associations with synovial mast cell proteases of rheumatoid arthritis patients and collagen-induced arthritis rats

Guo, Yaming; Wei, Tao; Hu, Nan; Zhou, Xiaoying

doi:10.1007/s12026-021-09231-2

Cited by 5 publications

(10 citation statements)

References 36 publications

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“…In the joint fluid of rheumatoid arthritis patients, a significant correlation between MMP-9 and polymorphonuclearleukocyte elastase levels was observed, and MMP-9 level was also correlated with the C-propeptide of type II collagen level, which reflects the synthesis of type II collagen and is up-regulated angiogenesis [ 70 ]. In a rat arthritis model, hyaluronic acid concentration was decreased, and MMP-9 activity was increased in synovial fluid [ 71 ]. In that model, chymase activity was significantly increased in the synovial fluid, and a significant positive correlation between chymase and MMP-9 activities was observed [ 71 ].…”

Section: Inflammatory Diseasesmentioning

confidence: 99%

“…In a rat arthritis model, hyaluronic acid concentration was decreased, and MMP-9 activity was increased in synovial fluid [ 71 ]. In that model, chymase activity was significantly increased in the synovial fluid, and a significant positive correlation between chymase and MMP-9 activities was observed [ 71 ]. Furthermore, hyaluronic acid concentration correlated negatively with chymase and MMP-9 activities [ 71 ].…”

Section: Inflammatory Diseasesmentioning

confidence: 99%

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Pathophysiological Role of Chymase-Activated Matrix Metalloproteinase-9

Takai

Jin

2022

Biomedicines

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Chymase present in mast cells can directly form matrix metalloproteinase (MMP)-9 from proMMP-9. Chymase-activated MMP-9 has been reportedly closely related to the pathogenesis of various diseases, and inflammation-related diseases in particular. Upregulated chymase and MMP-9 have been observed in tissues from patients and animal models of aortic aneurysm, inflammatory gastrointestinal and hepatic diseases, acute pancreatic failure, atopic dermatitis and rheumatoid arthritis. Chymase at these regions is only derived from mast cells, while MMP-9 is derived from macrophages and neutrophils in addition to mast cells. Chymase inhibitors attenuate MMP-9 formation from pro-MMP-9, and ameliorate the development and progression of these disorders, along with reduction in inflammatory cell numbers. MMP-9 activated by chymase might also be involved in angiogenesis in the tumor environment. Development of angiogenesis around several cancers is closely related to the expression of chymase and MMP-9, and postoperative survival curves have revealed that patients with a higher number of chymase positive cells have lower survival rates. In this review, we wanted to clarify the role of chymase-activated MMP-9, which might become an important therapeutic target for various inflammatory disorders.

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Section: Inflammatory Diseasesmentioning

confidence: 99%

Section: Inflammatory Diseasesmentioning

confidence: 99%

Pathophysiological Role of Chymase-Activated Matrix Metalloproteinase-9

Takai

Jin

2022

Biomedicines

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“…Secondly, granules of synovial MCs contain heparin, which represents the preliminary stage in the synthesis of HA. In vitro studies showed that MC chymase and tryptase accelerated the degradation of HA in the synovial fluid [ 51 ]. Moreover, MCs express the hyaluronic-acid-binding isoform of CD44 [ 52 ].…”

Section: Role Of Mast Cells In Oamentioning

confidence: 99%

Targeting Neuroinflammation in Osteoarthritis with Intra-Articular Adelmidrol

et al. 2022

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Neuroinflammation is an emerging therapeutic target in chronic degenerative and autoimmune diseases, such as osteoarthritis (OA) and rheumatoid arthritis. Mast cells (MCs) play a key role in the homeostasis of joints and the activation of MCs induces the release of a huge number of mediators, which fuel the fire of neuroinflammation. Particularly, synovial MCs release substances which accelerate the degradation of the extra-cellular matrix causing morphological joint changes and cartilage damage and inducing the proliferation of synovial fibroblasts, angiogenesis, and the sprouting of sensory nerve fibers, which mediate chronic pain. Palmitoylethanolamide (PEA) is a well-known MCs modulator, but in osteoarthritic joints, its levels are significantly reduced. Adelmidrol, a synthetic derivate of azelaic acid belonging to the ALIAmides family, is a PEA enhancer. Preclinical and clinical investigations showed that the intra-articular administration of Adelmidrol significantly reduced MC infiltration, pro-inflammatory cytokine release, and cartilage degeneration. The combination of 1% high molecular weight hyaluronic acid and 2% Adelmidrol has been effectively used for knee osteoarthritis and, a significant improvement in analgesia and functionality has been recorded.

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“…4 Similarly, a decrease in the concentration of hyaluronic acid in synovial fluid has been linked to a pejorative state in rheumatoid arthritis. 5 For this reason, it is clearly important to monitor the concentration of hyaluronic acid to guide clinical decisions. Synovial fluid is not the only biofluid where the concentration of macromolecules in solution is linked to disease states.…”

Section: Introductionmentioning

confidence: 99%

“…In the specific case of rheumatoid arthritis, changes in the level of hyaluronic acid have been associated with the inhibition of antithrombin with consequent deterioration of the joint tissue . Similarly, a decrease in the concentration of hyaluronic acid in synovial fluid has been linked to a pejorative state in rheumatoid arthritis . For this reason, it is clearly important to monitor the concentration of hyaluronic acid to guide clinical decisions.…”

Section: Introductionmentioning

confidence: 99%

Rapid Temperature-Dependent Rheological Measurements of Non-Newtonian Solutions Using a Machine-Learning Aided Microfluidic Rheometer

Giudice

Barnes

2022

Anal. Chem.

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Biofluids such as synovial fluid, blood plasma, and saliva contain several proteins which impart non-Newtonian properties to the biofluids. The concentration of such protein macromolecules in biofluids is regarded as an important biomarker for the diagnosis of several health conditions, including cardiovascular disorders, joint quality, and Alzheimer's. Existing technologies for the measurements of macromolecules in biofluids are limited; they require a long turnaround time, or require complex protocols, thus calling for alternative, more suitable, methodologies aimed at such measurements. According to the well-established relations for polymer solutions, the concentration of macromolecules in solutions can also be derived via measurement of rheological properties such as shear-viscosity and the longest relaxation time. We here introduce a microfluidic rheometer for rapid simultaneous measurement of shear viscosity and longest relaxation time of non-Newtonian solutions at different temperatures. At variance with previous technologies, our microfluidic rheometer provides a very short turnaround time of around 2 min or less thanks to the implementation of a machinelearning algorithm. We validated our platform on several aqueous solutions of poly(ethylene oxide). We also performed measurements on hyaluronic acid solutions in the clinical range for joint grade assessment. We observed monotonic behavior with the concentration for both rheological properties, thus speculating on their use as potential rheo-markers, i.e., rheological biomarkers, across several disease states.

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Disrupted homeostasis of synovial hyaluronic acid and its associations with synovial mast cell proteases of rheumatoid arthritis patients and collagen-induced arthritis rats

Cited by 5 publications

References 36 publications

Pathophysiological Role of Chymase-Activated Matrix Metalloproteinase-9

Pathophysiological Role of Chymase-Activated Matrix Metalloproteinase-9

Targeting Neuroinflammation in Osteoarthritis with Intra-Articular Adelmidrol

Rapid Temperature-Dependent Rheological Measurements of Non-Newtonian Solutions Using a Machine-Learning Aided Microfluidic Rheometer

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