Disrupted functional connectivity of the cerebellum with default mode and frontoparietal networks in young adults with major depressive disorder

Wang, Xiang; Xia, Jie; Wang, Weiyan; Lu, Jingjie; Liu, Qian; Fan, Jie; Soondrum, Tamini; Yu, Quanhao; Tan, Chongqing; Zhu, Xiongzhao

doi:10.1016/j.psychres.2023.115192

Cited by 7 publications

(4 citation statements)

References 80 publications

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“…Dysfunction within the cerebellum and frontal regions impairs the coordination and modulation of attention networks ( Arif et al, 2020 ). Damage to the tract and disruptions in neuronal synchronization between the cerebellum and frontal cortex may contribute to decreased functional connectivity ( Wang et al, 2023 ). Cognitive ability is affected by reduced connectivity between cortical regions, particularly the prefrontal cortex, and sub-cortical regions in schizophrenia ( Sheffield and Barch, 2016 ), bipolar disease ( Ursino et al, 2022 ), depression ( Liu et al, 2020 ), traumatic brain injury ( Morelli et al, 2021 ; Nakuci et al, 2021 ), stroke ( Wang et al, 2023 ), and functional seizure ( Foroughi et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Brain functional connectivity in hyperthyroid patients: systematic review

Tesfaye,

Getnet,

Anmut Bitew

et al. 2024

Front. Neurosci.

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IntroductionFunctional connectivity (FC) is the correlation between brain regions’ activities, studied through neuroimaging techniques like fMRI. It helps researchers understand brain function, organization, and dysfunction. Hyperthyroidism, characterized by high serum levels of free thyroxin and suppressed thyroid stimulating hormone, can lead to mood disturbance, cognitive impairment, and psychiatric symptoms. Excessive thyroid hormone exposure can enhance neuronal death and decrease brain volume, affecting memory, attention, emotion, vision, and motor planning.MethodsWe conducted thorough searches across Google Scholar, PubMed, Hinari, and Science Direct to locate pertinent articles containing original data investigating FC measures in individuals diagnosed with hyperthyroidism.ResultsThe systematic review identified 762 articles, excluding duplicates and non-matching titles and abstracts. Four full-text articles were included in this review. In conclusion, a strong bilateral hippocampal connection in hyperthyroid individuals suggests a possible neurobiological influence on brain networks that may affect cognitive and emotional processing.Systematic Review RegistrationPROSPERO, CRD42024516216.

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Section: Discussionmentioning

confidence: 99%

Brain functional connectivity in hyperthyroid patients: systematic review

Tesfaye,

Getnet,

Anmut Bitew

et al. 2024

Front. Neurosci.

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“…The cerebellum and lateral occipital cortex was also stimulated in our study. Cerebellum is connected to the fronto-parietal network, modulating cognitive and executive function ( Wang et al, 2023 ; Zhang et al, 2023 ). Disruption of this connectivity is associated with some neurological and psychiatric disease such as cognitive impairment or depression ( Wang et al, 2023 ; Zhang et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

“…Cerebellum is connected to the fronto-parietal network, modulating cognitive and executive function ( Wang et al, 2023 ; Zhang et al, 2023 ). Disruption of this connectivity is associated with some neurological and psychiatric disease such as cognitive impairment or depression ( Wang et al, 2023 ; Zhang et al, 2023 ). And, lateral occipital cortex involved in the representation and perception of objects and the decreased connectivity of lateral occipital cortex is associated with autism ( Jung et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Transcutaneous auricular vagus nerve stimulation can modulate fronto-parietal brain networks

Han,

Shim,

Lee

et al. 2024

Front. Neurosci.

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ObjectiveRecent studies have shown that transcutaneous vagal nerve stimulation (tVNS) holds promise as a treatment for neurological or psychiatric disease through the ability to modulate neural activity in some brain regions without an invasive procedure. The objective of this study was to identify the neural correlates underlying the effects of tVNS.MethodsTwenty right-handed healthy subjects with normal hearing participated in this study. An auricle-applied tVNS device (Soricle, Neurive Co., Ltd., Gyeongsangnam-do, Republic of Korea) was used to administer tVNS stimulation. A session consisted of 14 blocks, including 7 blocks of tVNS stimulation or sham stimulation and 7 blocks of rest, and lasted approximately 7 min (1 block = 30 s). Functional magnetic resonance imaging (fMRI) was performed during the stimulation.ResultsNo activated regions were observed in the fMRI scans following both sham stimulation and tVNS after the first session. After the second session, tVNS activated two clusters of brain regions in the right frontal gyrus. A comparison of the activated regions after the second session of each stimulation revealed that the fMRI following tVNS exhibited four surviving clusters. Additionally, four clusters were activated in the overall stimulated area during both the first and second sessions. When comparing the fMRI results after each type of stimulation, the fMRI following tVNS showed four surviving clusters compared to the fMRI after sham stimulation.ConclusiontVNS could stimulate some brain regions, including the fronto-parietal network. Stimulating these regions for treating neurological or psychiatric disease might require applying tVNS for at least 3.5 min.

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“…Previous resting-state functional magnetic resonance imaging (rs-fMRI) studies have shown that the DMN are strongly connected with the bilateral cerebellar Crus I, Crus II, and lobular IX subregions ( Buckner, Krienen, Castellanos, Diaz & Yeo, 2011 ; Diedrichsen, Balsters, Flavell, Cussans & Ramnani, 2009 ; Halko, Farzan & Eldaief, 2014 ). The abnormalities of resting-state static functional connectivity (sFC) and dynamic functional connectivity (dFC) in the cerebellum-DMN circuits were reported in MDD ( Ding et al, 2022 ; Wang et al, 2023 ; Zhu et al, 2020 ) and bipolar depression ( Chen et al, 2019 ; Luo et al, 2018 ). Moreover, it was found that patients with MDD showed improved FC in the cerebellum-DMN circuits after electroconvulsive therapy ( Wang et al, 2018 ) and antidepressant therapy ( Wang et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Bright light therapy-induced improvements of mood, cognitive functions and cerebellar functional connectivity in subthreshold depression: A randomized controlled trial

Chen,

Guo,

Chen

et al. 2024

International Journal of Clinical and Health Psychology

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Disrupted functional connectivity of the cerebellum with default mode and frontoparietal networks in young adults with major depressive disorder

Cited by 7 publications

References 80 publications

Brain functional connectivity in hyperthyroid patients: systematic review

Brain functional connectivity in hyperthyroid patients: systematic review

Transcutaneous auricular vagus nerve stimulation can modulate fronto-parietal brain networks

Bright light therapy-induced improvements of mood, cognitive functions and cerebellar functional connectivity in subthreshold depression: A randomized controlled trial

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