Disrupted functional connectivity of the hippocampus in patients with hyperthyroidism: Evidence from resting-state fMRI

Zhang, Wei; Liu, Xianjun; Zhang, Yi; Song, Lingheng; Hou, Jingming; Chen, Bing; He, Mei; Cai, Ping; Lii, Haitao

doi:10.1016/j.ejrad.2014.07.003

Cited by 39 publications

(36 citation statements)

References 29 publications

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“…Abnormal functional connectivity of DMN was reported to contribute to disrupted working memory [40, 41] and emotional processing [42–44]. Previous studies of hyperthyroidism have revealed impaired metabolism and FC in brain regions anchored in DMN [7–9, 12, 13]. The related brain regions of DMN in hyperthyroidism primarily included PCC [8, 9, 12], inferior frontal gyrus [13] and superior frontal gyrus [7].…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies of hyperthyroidism have revealed impaired metabolism and FC in brain regions anchored in DMN [7–9, 12, 13]. The related brain regions of DMN in hyperthyroidism primarily included PCC [8, 9, 12], inferior frontal gyrus [13] and superior frontal gyrus [7]. In the current study, we also found aberrant DMN functional connectivity in MeFG and PCu, and the FC between bilateral MeFG and PCu was negatively correlated with the processing speed Z scores.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, there are some resting-state functional connectivity (FC) studies showing aberrant functional connectivity of the brain in hyperthyroid patients. Zhang et al [12] defined the hippocampus as the seed region revealed decreased functional connectivity to bilateral anterior cingulate cortex (ACC), PCC and right medial orbitofrontal cortex. And the strength of functional connectivity was correlated with both the disease duration and depression level of hyperthyroidism.…”

Section: Introductionmentioning

confidence: 99%

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Abnormal brain functional connectivity leads to impaired mood and cognition in hyperthyroidism: a resting-state functional MRI study

et al. 2016

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Patients with hyperthyroidism frequently have neuropsychiatric complaints such as lack of concentration, poor memory, depression, anxiety, nervousness, and irritability, suggesting brain dysfunction. However, the underlying process of these symptoms remains unclear. Using resting-state functional magnetic resonance imaging (rs-fMRI), we depicted the altered graph theoretical metric degree centrality (DC) and seed-based resting-state functional connectivity (FC) in 33 hyperthyroid patients relative to 33 healthy controls. The peak points of significantly altered DC between the two groups were defined as the seed regions to calculate FC to the whole brain. Then, partial correlation analyses were performed between abnormal DC, FC and neuropsychological performances, as well as some clinical indexes. The decreased intrinsic functional connectivity in the posterior lobe of cerebellum (PLC) and medial frontal gyrus (MeFG), as well as the abnormal seed-based FC anchored in default mode network (DMN), attention network, visual network and cognitive network in this study, possibly constitutes the latent mechanism for emotional and cognitive changes in hyperthyroidism, including anxiety and impaired processing speed.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Abnormal brain functional connectivity leads to impaired mood and cognition in hyperthyroidism: a resting-state functional MRI study

et al. 2016

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“…A functional magnetic resonance imaging (fMRI) study using the N‐back working memory task revealed altered activation in brain regions such as the parahippocampal gyrus, supplementary motor area, prefrontal cortex, anterior cingulate cortex, posterior cerebellum, rolandic operculum and insula in thyrotoxicosis . Similarly, an earlier resting state network FC study in thyrotoxicosis patients reported weak FC strength between the hippocampus and bilateral anterior cingulate cortex, posterior cingulate cortex and right medial orbitofrontal cortex using hippocampus as the seed region . Liu et al showed increased FC in the bilateral anterior insula, bilateral posterior insula and left anterior lobe of the cerebellum, as well as a decreased FC in the bilateral lateral prefrontal cortex, right medial temporal gyrus and bilateral posterior cingulate cortex to be associated with hyperthyroidism.…”

Section: Introductionmentioning

confidence: 97%

“…Previous neuroimaging studies have shown morphological, functional, metabolite and perfusion weighted changes associated with thyrotoxicosis. A functional magnetic resonance imaging (fMRI) study using the N‐back working memory task revealed altered activation in brain regions such as the parahippocampal gyrus, supplementary motor area, prefrontal cortex, anterior cingulate cortex, posterior cerebellum, rolandic operculum and insula in thyrotoxicosis .…”

Section: Introductionmentioning

confidence: 99%

Aberrant intra and inter network resting state functional connectivity in thyrotoxicosis

Kumar

Rana

Modi

et al. 2019

J Neuroendocrinology

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Thyroid hormones epigenetically play an important role in the regularisation of neural networks and in neural differentiation during brain development. The present study aimed to explore the intra and inter network resting state functional connectivity changes underlying the neurobehavioural symptoms in thyrotoxicosis. To understand the pathophysiological changes, we investigated the correlation between functional connectivity and clinical and behavioural measures. Twenty-eight freshly diagnosed thyrotoxicosis patients suffering with symptoms such as palpitation, loss of weight, trembling and heat intolerance from days to weeks and 28 healthy controls were recruited for the study. Thyrotoxicosis patients showed significantly decreased functional connectivity in sensorimotor network, fronto-temporal network, default mode network, right fronto-parietal network, left fronto-parietal network and salience network. Inter network functional connectivity was significantly reduced between the basal ganglia network and sensorimotor network and increased between the salience network and fronto-temporal network in thyrotoxicosis. Cognitive functions such as visual retention, recognition of objects, mental balance and performance on neuropsychological tests (ie, the Bender Gestalt test, Nahar-Benson test and Mini Mental State Examination) also showed significant decline in thyrotoxicosis patients. The altered intrinsic resting state functional connectivity might underlie these cognitive deficits. The increased functional connectivity between the salience network and fronto-temporal network suggests the recruitment of additional neuronal circuitry needed to compensate for the neuropathology in the primary neural network in thyrotoxicosis. K E Y W O R D S functional connectivity, independent components, inter network, intra network, resting state network, thyrotoxicosis

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Hippocampal atrophy and functional connectivity disruption in cirrhotic patients with minimal hepatic encephalopathy

Lin

Chen

Gao³

et al. 2019

Metab Brain Dis

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Disrupted functional connectivity of the hippocampus in patients with hyperthyroidism: Evidence from resting-state fMRI

Cited by 39 publications

References 29 publications

Abnormal brain functional connectivity leads to impaired mood and cognition in hyperthyroidism: a resting-state functional MRI study

Abnormal brain functional connectivity leads to impaired mood and cognition in hyperthyroidism: a resting-state functional MRI study

Aberrant intra and inter network resting state functional connectivity in thyrotoxicosis

Hippocampal atrophy and functional connectivity disruption in cirrhotic patients with minimal hepatic encephalopathy

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