Disrupted Daytime Activity and Altered Sleep-Wake Patterns May Predict Transition to Mild Cognitive Impairment or Dementia

Covell, Gretchen E. Schlosser; Dhawan, Priya S.; Iannotti, Joyce K. Lee; Hoffman-Snyder, Charlene; Wellik, Kay E.; Caselli, Richard J.; Woodruff, Bryan K.; Wingerchuk, Dean M.; Demaerschalk, Bart M.

doi:10.1097/nrl.0b013e318272f7ef

Cited by 50 publications

(42 citation statements)

References 12 publications

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“…In this sense, Cochrane et al (2012) [25] observed a phase delay in this rhythm in MCI subjects. Furthermore, other studies have identified this phase delay of the rest-activity rhythm as a predictor for developing MCI [9, 10]. However, a recent study combining polysomnography, actigraphy, and melatonin analysis showed a clear phase advance in sleep and dim light melatonin onset in patients with MCI [11], similar to that observed by us using rhythmic multivariable recordings.…”

Section: Discussionsupporting

confidence: 74%

“…This circadian alteration is similar to that observed during normal aging, since elderly people consistently show a phase advance in their circadian rhythms [2]. This discrepancy between our study and the results of Cochrane (2012) [25], Schlosser Covell et al (2012) [10], and Tranah (2011) [9] could be possibly attributed to how phases are calculated. These authors calculate the acrophase of the rest-activity rhythm using the cosinor method.…”

Section: Discussionsupporting

confidence: 59%

“…Compared to the relatively large number of articles devoted to the study of circadian alterations in AD, only scarce and sometimes contradictory data are available on the possible impairment of the circadian system in MCI. In this sense, a phase delay of the rest-activity rhythm has been recognized as a risk factor for developing MCI [9, 10]. On the contrary, a phase advance in the dim light melatonin onset, the gold standard for circadian phase assessment, has been reported in MCI patients [11].…”

Section: Introductionmentioning

confidence: 99%

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The Characterization of Biological Rhythms in Mild Cognitive Impairment

Ortiz‐Tudela

Martínez-Nicolás

Díaz-Mardomingo

et al. 2014

BioMed Research International

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Introduction. Patients with dementia, especially Alzheimer's disease, present several circadian impairments related to an accelerated perturbation of their biological clock that is caused by the illness itself and not merely age-related. Thus, the objective of this work was to elucidate whether these circadian system alterations were already present in patients with mild cognitive impairment (MCI), as compared to healthy age-matched subjects. Methods. 40 subjects (21 patients diagnosed with MCI, 74.1 ± 1.5 y.o., and 19 healthy subjects, 71.7 ± 1.4 y.o.) were subjected to ambulatory monitoring, recording wrist skin temperature, motor activity, body position, and the integrated variable TAP (including temperature, activity, and position) for one week. Nonparametrical analyses were then applied. Results. MCI patients exhibited a significant phase advance with respect to the healthy group for the following phase markers: temperature M5 (mean ± SEM: 04:20 ± 00:21 versus 02:52 ± 00:21) and L10 (14:35 ± 00:27 versus 13:24 ± 00:16) and TAP L5 (04:18 ± 00:14 versus 02:55 ± 00:30) and M10 (14:30 ± 00:18 versus 13:28 ± 00:23). Conclusions. These results suggest that significant advances in the biological clock begin to occur in MCI patients, evidenced by an accelerated aging of the circadian clock, as compared to a healthy population of the same age.

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Section: Discussionsupporting

confidence: 74%

Section: Discussionsupporting

confidence: 59%

Section: Introductionmentioning

confidence: 99%

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The Characterization of Biological Rhythms in Mild Cognitive Impairment

Ortiz‐Tudela

Martínez-Nicolás

Díaz-Mardomingo

et al. 2014

BioMed Research International

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“…Recent clinical studies have found that age-related declines in circadian function can lead to mild cognitive impairment or dementia (2, 3). These memory deficits are not simply a consequence of poorer sleep, because reductions in circadian rhythm amplitude and robustness can accelerate progression of mild cognitive impairment or dementia even when sleep quality is maintained (2, 3). The observation that circadian timing is substantially weakened among people with Alzheimer's disease has raised the possibility that cognitive deficits might be treated by improving circadian function (4–6).…”

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confidence: 99%

Dysrhythmia in the suprachiasmatic nucleus inhibits memory processing

Fernandez

et al. 2014

Science

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Chronic circadian dysfunction impairs declarative memory in humans but has little effect in common rodent models of arrhythmia caused by clock gene knockouts or surgical ablation of the suprachiasmatic nucleus (SCN). An important problem overlooked in these translational models is that human dysrhythmia occurs while SCN circuitry is genetically and neurologically intact. Siberian hamsters (Phodopus sungorus) are particularly well suited for translational studies because they can be made arrhythmic by a one-time photic treatment that severely impairs spatial and recognition memory. We found that once animals are made arrhythmic, subsequent SCN ablation completely rescues memory processing. These data suggest that the inhibitory effects of a malfunctioning SCN on cognition require preservation of circuitry between the SCN and downstream targets that are lost when these connections are severed.

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“…However, recent research suggests circadian dysfunction contributes to and escalates neurodegenerative pathologies (Musiek 2015). In clinical studies, dampened or shifted circadian rhythms in aging individuals were predictive of increased risk of mild cognitive impairments and dementia (Tranah et al 2011;Schlosser Covell et al 2012). Similarly, weaker circadian rhythms were also predictive of future cognitive impairments in older individuals without dementia (Walsh et al 2014).…”

Section: The Circadian Clock Aging and Neurodegenerative Diseasesmentioning

confidence: 99%

Synchrony and desynchrony in circadian clocks: impacts on learning and memory

Krishnan

Lyons

2015

Learn. Mem.

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Circadian clocks evolved under conditions of environmental variation, primarily alternating light dark cycles, to enable organisms to anticipate daily environmental events and coordinate metabolic, physiological, and behavioral activities. However, modern lifestyle and advances in technology have increased the percentage of individuals working in phases misaligned with natural circadian activity rhythms. Endogenous circadian oscillators modulate alertness, the acquisition of learning, memory formation, and the recall of memory with examples of circadian modulation of memory observed across phyla from invertebrates to humans. Cognitive performance and memory are significantly diminished when occurring out of phase with natural circadian rhythms. Disruptions in circadian regulation can lead to impairment in the formation of memories and manifestation of other cognitive deficits. This review explores the types of interactions through which the circadian clock modulates cognition, highlights recent progress in identifying mechanistic interactions between the circadian system and the processes involved in memory formation, and outlines methods used to remediate circadian perturbations and reinforce circadian adaptation.Circadian clocks permit organisms to anticipate recurring daily environmental events through the coordination of metabolic, physiological, and behavioral rhythms. Conservation of the core principles through which circadian oscillators are organized across eukaryotic phyla suggests strong selective pressures for both circadian clocks and the mechanisms through which circadian oscillators operate. Intracellularly, transcription/translation feedback loops involving core circadian components set the stage for transcriptional regulation of thousands of genes in individual cells and tissues (Balsalobre et al.

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Disrupted Daytime Activity and Altered Sleep-Wake Patterns May Predict Transition to Mild Cognitive Impairment or Dementia

Abstract: Disrupted circadian rhythm measures, including lower amplitude, a less robust rhythm, and delayed timing of peak activity on wrist actigraphy, were predictive of future development of MCI or dementia in cognitively normal women.

Cited by 50 publications

References 12 publications

The Characterization of Biological Rhythms in Mild Cognitive Impairment

The Characterization of Biological Rhythms in Mild Cognitive Impairment

Dysrhythmia in the suprachiasmatic nucleus inhibits memory processing

Synchrony and desynchrony in circadian clocks: impacts on learning and memory

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