Disrupted Brain Network Efficiency and Decreased Functional Connectivity in Multi-sensory Modality Regions in Male Patients With Alcohol Use Disorder

Wang, Yaqi; Zhao, Yilin; Nie, Hanxiang; Liu, Changsheng; Chen, Jun

doi:10.3389/fnhum.2018.00513

Cited by 28 publications

(50 citation statements)

References 53 publications

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“…Additionally, these brain abnormalities have been closely related to multisensory stimuli (Volkow et al, 2011b). The decreased activation of cognitive control circuits in the frontal region was likely to cause emotional disorder and cognitive or motivational dysfunction in people with addictions (Volkow et al, 2011a;Zhang L. et al, 2018) and caused the crossmodal emotional integration disorder as well (Yalachkov et al, 2012;Wang et al, 2018). The results of Experiment 1 were strongly consistent with our expectations that MADs showed poor fear recognition with crossmodal processing.…”

Section: Discussionsupporting

confidence: 83%

“…In addition, the PFC and olfactory play a key role in the convergence of crossmodal signals (Klasen et al, 2012;Yalachkov et al, 2012). Wang et al (2018) reported the abnormal functional connection between the left OFC and DLPFC in an alcohol-dependent group. These results suggest that alcoholism and MADs may share a similar neural mechanism linked to crossmodal.…”

Section: Introductionmentioning

confidence: 99%

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Facilitation of Crossmodal Integration During Emotional Prediction in Methamphetamine Dependents

Zhang

et al. 2020

Front. Neural Circuits

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Methamphetamine (meth) can greatly damage the prefrontal cortex of the brain and trigger dysfunction of the cognitive control loop, which triggers not only drug dependence but also emotional disorders. The imbalance between the cognitive and emotional systems will lead to crossmodal emotional deficits. Until now, the negative impact of meth dependence on crossmodal emotional processing has not received attention. Therefore, the present study firstly examined the differences in crossmodal emotional processing between healthy controls and meth dependents (MADs) and then investigated the role of visual-or auditory-leading cues in the promotion of crossmodal emotional processing. Experiment 1 found that MADs made a visual-auditory integration disorder for fearful emotion, which may be related to the defects in information transmission between the auditory and auditory cortex. Experiment 2 found that MADs had a crossmodal disorder pertaining to fear under visual-leading cues, but the fearful sound improved the detection of facial emotions for MADs. Experiment 3 reconfirmed that, for MADs, A-leading cues could induce crossmodal integration immediately more easily than V-leading ones. These findings provided sufficient quantitative indicators and evidences that meth dependence was associated with crossmodal integration disorders, which in turn was associated with auditory-leading cues that enhanced the recognition ability of MADs for complex emotions (all results are available at: https://osf. io/x6rv5/). These results provided a better understanding for individuals using drugs in order to enhance the cognition for the complex crossmodal emotional integration.

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Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Facilitation of Crossmodal Integration During Emotional Prediction in Methamphetamine Dependents

Zhang

et al. 2020

Front. Neural Circuits

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“…Finally, the IC group showed a lower global efficiency, similar results have been recently reported for alcohol-dependent patients. Sjoerds et al (66) reported that resting brain functions were less efficient with longer alcohol dependence duration, while Wang et al (67) found that brain networks of adult patients with alcohol use disorder showed decreased global efficiency compared to those of controls. Our results are consistent with previous research and suggest a diminishing in the efficiency of functional connectivity in individuals with SUDs.…”

Section: Discussionmentioning

confidence: 99%

Default Mode Network Efficiency Is Correlated With Deficits in Inhibition in Adolescents With Inhalant Use Disorder

et al. 2020

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It is well established that alterations in cognitive function and damage to brain structures are often found in adolescents who have substance use disorder (SUD). However, deficits in executive cognitive functioning in adolescents related to the vulnerability and consumption of such substances are not well known. In this study, we use graph theoretic analysis to compare the network efficiency in the resting state for three networks-default mode network (DMN), salience network (SN) and fronto-parietal network (FPN)-between inhalant-consuming adolescents and a control group (12 to 17 years old). We analyzed whether the efficiency of these functional networks was related to working memory, mental flexibility, inhibition of response, and sequential planning. We found that, when compared to the control group, inhalant-consuming adolescents presented with important deficits in communication among brain regions that comprise the DMN, SN, and FPN networks. DMN is the most affected network by inhalant abuse during adolescence. The mediation analyses suggested that the relationship between inhalant abuse and inhibitory control and sequential planning was partly mediated by DMN efficiency.

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“…Given that Z is low when a high number of nodes are unreachable from one another, this metric also captures the extent of network connectivity. Thus, a fault-tolerant network, which, by definition, is able to maintain connectivity despite the removal of certain nodes, exhibits a high Z. In fact, network efficiency has been utilized to study disruption in information propagation in functional brain networks 54,55 . Here, we quantify effect of a specific set of nodes on the fault-tolerance of a network by recording the drop in Z when such nodes are knocked off.…”

Section: 22 and 223)mentioning

confidence: 99%

Motifs enable communication efficiency and fault-tolerance in transcriptional networks

Roy

Ghosh

Barua

et al. 2020

Sci Rep

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Analysis of the topology of transcriptional regulatory networks (TRNs) is an effective way to study the regulatory interactions between the transcription factors (TFs) and the target genes. TRNs are characterized by the abundance of motifs such as feed forward loops (FFLs), which contribute to their structural and functional properties. In this paper, we focus on the role of motifs (specifically, FFLs) in signal propagation in TRNs and the organization of the TRN topology with FFLs as building blocks. To this end, we classify nodes participating in FFLs (termed motif central nodes) into three distinct roles (namely, roles A, B and C), and contrast them with TRN nodes having high connectivity on the basis of their potential for information dissemination, using metrics such as network efficiency, path enumeration, epidemic models and standard graph centrality measures. We also present the notion of a three tier architecture and how it can help study the structural properties of TRN based on connectivity and clustering tendency of motif central nodes. Finally, we motivate the potential implication of the structural properties of motif centrality in design of efficient protocols of information routing in communication networks as well as their functional properties in global regulation and stress response to study specific disease conditions and identification of drug targets.

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Disrupted Brain Network Efficiency and Decreased Functional Connectivity in Multi-sensory Modality Regions in Male Patients With Alcohol Use Disorder

Cited by 28 publications

References 53 publications

Facilitation of Crossmodal Integration During Emotional Prediction in Methamphetamine Dependents

Facilitation of Crossmodal Integration During Emotional Prediction in Methamphetamine Dependents

Default Mode Network Efficiency Is Correlated With Deficits in Inhibition in Adolescents With Inhalant Use Disorder

Motifs enable communication efficiency and fault-tolerance in transcriptional networks

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