Disrupted amygdala-prefrontal connectivity during emotion regulation links stress-reactive rumination and adolescent depressive symptoms

Fowler, Carina H.; Miernicki, Michelle E.; Rudolph, Karen D.; Telzer, Eva H.

doi:10.1016/j.dcn.2017.09.002

Cited by 43 publications

(37 citation statements)

References 62 publications

(83 reference statements)

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“…We estimated a sample size based on previous work that examined developmental differences (as measured by a continuous variable representing age or puberty) in brain responses to face stimuli (N=45; Fowler, Miernicki, Rudolph, & Telzer, 2017) and N=41; . However, given expected data loss due to difficulty remaining motionless in the scanner (Fowler et al, 2017;Klapwijk et al, 2013) and task performance in previous work , we collected data from 61 participants (28 female; ages 6-13 years, mean(SD) age = 9.20(2.15)). All participants were Caucasian to control for any cross-race effects when rating Caucasian faces.…”

Section: Participantsmentioning

confidence: 99%

Exploring valence bias as a metric for frontoamygdalar connectivity and depressive symptoms in childhood

Petro

Tottenham²,

Neta

2019

Preprint

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Negativity bias is a core feature of depression that is associated with dysfunctional frontoamygdalar connectivity; this pathway is associated with emotion regulation and sensitive to neurobiological change during puberty. We used a valence bias task (ratings of emotional ambiguity) as a potential early indicator of depression risk and differences in frontoamygdalar connectivity. Previous work using this task demonstrated that children normatively have a negative bias that attenuates with maturation. Here, we test the hypothesis that persistence of this negativity bias as manturation ensues may reveal differences in emotion regulation development, and may be associated with increased risk for depression. Within a restricted age range (6-13 years), we tested the moderating role of puberty on relationships between valence bias, depressive symptoms, and frontoamygdalar connectivity. A negative bias was associated with increased depressive symptoms for those at more advanced pubertal stages (within this sample) and less regulatory frontoamygdalar connectivity, whereas a more positive bias was associated with more regulatory connectivity patterns. These data suggest that with maturation, individual differences in positivity biases and associated emotion regulation circuitry confer a differential risk for depression. Longitudinal work is necessary to determine the directionality of these effects and explore the influence of early life events.

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Section: Participantsmentioning

confidence: 99%

Exploring valence bias as a metric for frontoamygdalar connectivity and depressive symptoms in childhood

Petro

Tottenham²,

Neta

2019

Preprint

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“…RSA mediates the association between stress and anxiety [55] Amygdala-vlPFC connectivity during incidental emotion regulation mediates the relationship between rumination and depressive symptoms [60]…”

Section: Cognitive Reappraisal Mediates Link Between Depressive Symptmentioning

confidence: 99%

Positive and negative emotion regulation in adolescence: links to anxiety and depression

Young¹,

Sandman²,

Craske³

2019

Preprint

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Emotion regulation skills develop substantially across adolescence, a period characterized by emotional challenges and developing regulatory neural circuitry. Adolescence is also a risk period for the new onset of anxiety and depressive disorders, psychopathologies which have long been associated with disruptions in regulation of positive and negative emotions. This paper reviews the current understanding of the role of disrupted emotion regulation in adolescent anxiety and depression, describing findings from self-report, behavioral, peripheral psychophysiological, and neural measures. Self-report studies robustly identified associations between emotion dysregulation and adolescent anxiety and depression. Findings from behavioral and psychophysiological studies are mixed, with some suggestion of specific impairments in reappraisal in anxiety. Results from neuroimaging studies broadly implicate altered functioning of amygdala-prefrontal cortical circuitries, although again, findings are mixed regarding specific patterns of altered neural functioning. Future work may benefit from focusing on designs that contrast effects of specific regulatory strategies, and isolate changes in emotional regulation from emotional reactivity. Approaches to improve treatments based on empirical evidence of disrupted emotion regulation in adolescents are also discussed. Future intervention studies might consider training and measurement of specific strategies in adolescents to better understand the role of emotion regulation as a treatment mechanism.

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“…Symptoms of many of these disorders often begin in adolescence. For example, rates of major depressive disorder sharply increase between the ages of 15 and 18 (Hankin et al, 1998), and difficulties in ER have been linked with adolescent depression (Silk et al, 2003;Fowler et al, 2017). Thus, a detailed understanding of the neurobiological processes involved in ER during adolescence is critical for the development of prevention and treatment for both internalizing and externalizing disorders.…”

Section: Introductionmentioning

confidence: 99%

TEAMwork: Testing Emotional Attunement and Mutuality During Parent-Adolescent fMRI

Kerr

Cosgrove

Ratliff

et al. 2020

Front. Hum. Neurosci.

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The parent-child relationship and family context influence the development of emotion regulation (ER) brain circuitry and related skills in children and adolescents. Although both parents' and children's ER neurocircuitry simultaneously affect how they interact with one another, neuroimaging studies of parent-child relationships typically include only one member of the dyad in brain imaging procedures. The current study examined brain activation related to parenting and ER in parent-adolescent dyads during concurrent fMRI scanning with a novel task -the Testing Emotional Attunement and Mutuality (TEAM) task. The TEAM task includes feedback trials indicating the other dyad member made an error, resulting in a monetary loss for both participants. Results indicate that positive parenting practices as reported by the adolescent were positively correlated with parents' hemodynamic activation of the ventromedial prefrontal cortex, a region related to empathy, during these error trials. Additionally, during feedback conditions both parents and adolescents exhibited fMRI activation in ER-related regions, including the dorsolateral prefrontal cortex, anterior insula, fusiform gyrus, thalamus, caudate, precuneus, and superior parietal lobule. Adolescents had higher left amygdala activation than parents during the feedback condition. These findings demonstrate the utility of dyadic fMRI scanning for investigating relational processes, particularly in the parent-child relationship.

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Disrupted amygdala-prefrontal connectivity during emotion regulation links stress-reactive rumination and adolescent depressive symptoms

Cited by 43 publications

References 62 publications

Exploring valence bias as a metric for frontoamygdalar connectivity and depressive symptoms in childhood

Exploring valence bias as a metric for frontoamygdalar connectivity and depressive symptoms in childhood

Positive and negative emotion regulation in adolescence: links to anxiety and depression

TEAMwork: Testing Emotional Attunement and Mutuality During Parent-Adolescent fMRI

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