This article has been prepared in the light of a current tragedy with global impact: Syrian Civil War. The rationale and importance of this research lie on the requirement to study the involvement of some international organizations for ending the crisis. This can make a significant contribution to the literature as it addresses a substantial topic in the field. The purpose of this study is to make analyses and assessments about the practicality of some scenarios into the civil war. In this regard, total six scenarios (UN Only, NATO Only, NATO-UN Together, NATO-EU Together, Coalition Forces (TUR, the US, Russian Federation (RF) and Regional Organizations) have been clarified. Upon these scenarios, qualitative research method and comparative design have been followed. Conclusions could be drawn on whether any possible related scenarios would be reasonable, decisive and coherent with regional realities, current capabilities and international dynamics. At the end of the research, it has been concluded that most of these scenarios would not be applicable, reasonable and successful in Syria and could even worsen the current situation and trigger wider conflicts in the Middle East. However, a coalition of Turkey, the US and RF, although it is difficult to establish, comes out as the best scenario to end the civil war. This scenario covers most of the conditions required to end the civil war, establish a unified, democratic and peaceful Syria and restore peace, order and stability in post-civil war environment in the Middle East.