Disposition of sulfadimidine and its N<sub>4</sub>‐acetyl and hydroxy metabolites in horse plasma

Nouws, J. F. M.; Vree, T. B.; Baakman, M.; Driessens, F. C. M.; Smulders, Anthony P.; J, Holtkamp

doi:10.1111/j.1365-2885.1985.tb00960.x

Cited by 21 publications

(13 citation statements)

References 15 publications

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“…At high plasma SDM concentrations (higher than 100 pg/m1) the percentage of protein binding for SDM and its metabolites was relatively less (Table 2), which has been reported previously (6,10,12,13,18 From the public health point of view it has to be emphasized that SDM is acetylated very rapidly and completely in human beings. The N,-SDM is eliminated by tubular secretion, and hydroxylation of SDM is in man a minor elimination pathway (14,16,18).…”

Section: Discussionsupporting

confidence: 63%

“…(13) (10) x) Calculated from data in the final elimination phase (SDM concentration lower than 20 pg/ml) = Level not achieved ( )= in brackets the standard deviation.…”

Section: Resultsmentioning

confidence: 99%

“…Recently, two hydroxy metabolites of sulphadimidine were isolated from canine urine; they were purified and their molecular structures clarified (15,17,18). Specific High Performance Liquid Chromatographic (HPLC) methods were developed for the simultaneous determination of SDM, its Nracetyl and two hydroxy metabolites in plasma and milk (10,17,18).…”

Section: Introductionmentioning

confidence: 99%

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Dose dependent disposition of sulphadimidine and of its N₄‐acetyl and hydroxy metabolites in plasma and milk of dairy cows

Nouws¹,

Vree

Breukink

et al. 1985

Veterinary Quarterly

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(1985) Dose dependent disposition of sulphadimidine and of its N 4 -acetyl and hydroxy metabolites in plasma and milk of dairy cows, Veterinary Quarterly, 7:3, 177-186, DOI: 10.1080/01652176.1985 SUMMARY The disposition of sulphadimidine (SDM) and of its N 4-acetyl (N4-SDM) and two hydroxy metabolites, 6-hydroxymethyl-(SCH,OH) and 5-hydroxyasulphadimidine (SOH), was studied in plasma and milk of dairy cows following intramuscular or intravenous administration of sulphadimididine-33.3% at doses of 10, 45, 50, and 100 mg/kg. The main metabolite in plasma as well as in milk was SCH,OH. The metabolite percentages, the final plasma elimination half-lives, and the time of peak SDM concentrations in milk are presented for different dosages. The concentrations of SDM and its metabolites in milk ran parallel to those in plasma beyond 4 hours p.i. The metabolite concentrations in plasma and milk were lower than those of the parent SDM. Sulphate and glucuronide metabolites could not be detected in milk. At high doses (45 mg/kg or more) and SDM plasma concentrations exceeding 20 pg/ml, a capacity limited metabolism of SDM to SCH2OH was noticed, viz, a steady state concentration of SCH,OH and a biphasic elimination pattern for SDM and SCH,OH in plasma and milk. The mean ultrafiltrate ratios of the milk to plasma concentrations with respect to SDM, SCH,OH, SOH, and 114-SDM were: 0.69, 0.22, 020, and 0.63, respectively. The total amount of SDM and its metabolites recovered from the milk after milking twice daily over the whole experimental time was less than 2% of the applied dose. A bioassay method allowed of detecting qualitatively SDM concentrations exceeding 0.2 pg/ml in plasma or milk. Withholding times for edible tissues and milk are suggested.

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Section: Discussionsupporting

confidence: 63%

“…(13) (10) x) Calculated from data in the final elimination phase (SDM concentration lower than 20 pg/ml) = Level not achieved ( )= in brackets the standard deviation.…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dose dependent disposition of sulphadimidine and of its N₄‐acetyl and hydroxy metabolites in plasma and milk of dairy cows

Nouws¹,

Vree

Breukink

et al. 1985

Veterinary Quarterly

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“…The novel oxidation pathways of sulphapyridine and sulphadiazine were (7,8,10,11). For instance, 100 mg/kg sulphadimidine shows capacity-limited elimination in the cow and hen, but not in the horse (7,8,10).…”

Section: Discussionmentioning

confidence: 99%

“…For instance, 100 mg/kg sulphadimidine shows capacity-limited elimination in the cow and hen, but not in the horse (7,8,10). Disease state may also limit the metabolic capacity of the animal (2,9).…”

Section: Discussionmentioning

confidence: 99%

Novel oxidative pathways of sulphapyridine and sulphadiazine by the turtlePseudemys scripta elegans

Vree

Vree²,

Kolmer

1991

Veterinary Quarterly

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SUMMARY.The sulphonamides sulphapyridine and sulphadiazine show novel hydroxy metabolites in the turtle Pseudemys scripta elegans. In the excreta of the turtles the monohydroxy metabolites 4-hydroxy-and 5-hydroxysulphapyridine and the dihydroxy metabolite 4,5-dihydroxysulphapyridine were detected.Of sulphadiazine only dihydroxy metabolites 4,5-and 4,6-dihydroxysulphadiazine were detected. About 70-90% of the dose of sulphapyridine was recovered, while this figure varied between 48 and 69% for sulphadiazine.

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Effect of different sulfadimidine addition methods on its degradation behaviour in swine manure

Ren

Yan

et al. 2017

Environ Sci Pollut Res

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Sulfadimidine (SM2) is commonly used in the swine industry and enters the environment via faeces. In recent years, advances in the ecotoxicology of SM2 have become a popular research interest with two common research methods including swine manure collection from swine fed with a diet containing SM2 and directly adding SM2. The purpose of this experiment was to compare SM2 degradation behaviour in pig manure with two different SM2 addition methods. The results showed that the degradation half-lives of SM2 in manure from SM2-fed swine treatment were 33.2 and 32.0 days at the initial addition level of SM2 at 32.1 and 64.3 mg/kg, respectively. This was significantly longer than that in manure directly adding SM2 treatment with the half-lives of 21.4 and 14.8 days. The metabolite of SM2 N-acetyl-sulfamethazine occurred in manure from SM2-fed swine treatment but was not detected in directly adding SM2 treatment. The pH in manure from SM2-fed swine treatment was significantly lower than that in directly adding SM2 treatment, but the values of organic carbon, total nitrogen, and electrical conductivity in manure from SM2-fed swine treatment were significantly higher than those in manure directly adding SM2 treatment. Meanwhile, although the copy number of bacteria had no significant difference between two treatments, there was a significant difference in bacteria diversity. Results of the present study demonstrated that the presence of the metabolites, chemical property, and microbial diversity might be the reason for different SM2 degradation behaviours on different addition methods. Thus, the method using manure with SM2 collected from swine could obtain more accurate results for the ecotoxicological study of SM2.

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Disposition of sulfadimidine and its N₄‐acetyl and hydroxy metabolites in horse plasma

Cited by 21 publications

References 15 publications

Dose dependent disposition of sulphadimidine and of its N₄‐acetyl and hydroxy metabolites in plasma and milk of dairy cows

Dose dependent disposition of sulphadimidine and of its N₄‐acetyl and hydroxy metabolites in plasma and milk of dairy cows

Novel oxidative pathways of sulphapyridine and sulphadiazine by the turtlePseudemys scripta elegans

Effect of different sulfadimidine addition methods on its degradation behaviour in swine manure

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Disposition of sulfadimidine and its N4‐acetyl and hydroxy metabolites in horse plasma

Cited by 21 publications

References 15 publications

Dose dependent disposition of sulphadimidine and of its N4‐acetyl and hydroxy metabolites in plasma and milk of dairy cows

Dose dependent disposition of sulphadimidine and of its N4‐acetyl and hydroxy metabolites in plasma and milk of dairy cows

Novel oxidative pathways of sulphapyridine and sulphadiazine by the turtlePseudemys scripta elegans

Effect of different sulfadimidine addition methods on its degradation behaviour in swine manure

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Product

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Disposition of sulfadimidine and its N₄‐acetyl and hydroxy metabolites in horse plasma

Dose dependent disposition of sulphadimidine and of its N₄‐acetyl and hydroxy metabolites in plasma and milk of dairy cows

Dose dependent disposition of sulphadimidine and of its N₄‐acetyl and hydroxy metabolites in plasma and milk of dairy cows