Disposition of Nitrofurantoin and Nitrofurazone in the Isolated Perfused Rat Kidney

Phytotoxicity of New Furan-derived Aminophosphonic Acids, N-Aryl Furaldimines and 5-Nitrofuraldimine

“…But the largest and most common group of drugs bearing a furan moiety derives from 5-nitrofurfural. Their action is based on the redox enzymatic reaction of nitrofurfural, which is reduced by nitroreductase enzymes to an active radical reacting with nucleic acids and proteins. − Although nitrofurfural-deriving antimicrobial chemotherapeutics (nitrofurantoin, nifuroxazide etc.) became generally less popular due to adverse effects, it is to stress that nifurtimox, apart from benznidazole is a second effective drug for treatment of Trypanosoma cruzi or Trypanosoma brucei infections (Chagas disease and sleeping sickness) .…”

Generation of drug metabolite antigenicity in the intestinal mucosa

“…Since most drugs are administered orally, the gastrointestinal tract mucosa in particular warrants assessments in this respect. For this purpose we choose to study its possible capacity to confer antigenicity on nitrofurantoin, because this drug commonly causes adverse reactions which may be immunologically mediated (Holmberg et al, 1980), and its metabolism has been studied (Hoener and Krueger, 1984;Moreno et al, 1984). The objective was to show whether rat intestinal walls contained enzymes that could not only reduce nitrofurantoin but also conjugate the reduction product(s) to protein and to determine whether the protein conjugate so formed was immunogenic with respect to the hapten.…”