Abstract:The risk assessment of bisphenol A (BPA) on the development of offspring of humans is an important issue. There have been some reports on the fate of BPA in rodents, but information on the BPA level in fetal organs essential for the extrapolation to humans is inadequate. In the present study, we investigated the distribution pattern of 14 C-BPA-derived radioactivity in fetal tissues following administration of 10 mg/kg 14 C-BPA to the pregnant mice. The radioactivity was rapidly transferred through placenta an… Show more
“…Many studies of BPA and embryo/fetal development have focused on possible estrogenic effects at the early stages of development. Independent studies have documented the distribution of BPA and BPA metabolites from mother to conceptus during pregnancy (Miyakoda et al, 1999, 2000; Domoradzki et al, 2003; Zalko et al, 2003; Kawamoto et al, 2005). They note that BPA, but not BPA glucuronide, distributes readily to the fetus.…”
Section: Developmental Toxicity Studies In Laboratory Rodentsmentioning
Bisphenol A (BPA) exposure has been documented in pregnant women, but consequences for development are not yet widely studied in human populations. This review presents research on the consequences for offspring of BPA exposure during pregnancy. Extensive work in laboratory rodents has evaluated survival and growth of the conceptus, interference with embryonic programs of development, morphological sex differentiation, sex differentiation of the brain and behavior, immune responsiveness, and mechanism of action. Sensitive measures include RAR, aryl hydrocarbon receptor, and Hox A10 gene expression, anogenital distance, sex differentiation of affective and exploratory behavior, and immune hyperresponsiveness. Many BPA effects are reported at low doses (10-50 µg/kg d range) by the oral route of administration. At high doses (>500,000 µg/kg d) fetal viability is compromised. Much of the work has centered around the implications of the estrogenic actions of this agent. Some work related to thyroid mechanism of action has also been explored. BPA research has actively integrated current knowledge of developmental biology, concepts of endocrine disruption, and toxicological research to provide a basis for human health risk assessment.
“…Many studies of BPA and embryo/fetal development have focused on possible estrogenic effects at the early stages of development. Independent studies have documented the distribution of BPA and BPA metabolites from mother to conceptus during pregnancy (Miyakoda et al, 1999, 2000; Domoradzki et al, 2003; Zalko et al, 2003; Kawamoto et al, 2005). They note that BPA, but not BPA glucuronide, distributes readily to the fetus.…”
Section: Developmental Toxicity Studies In Laboratory Rodentsmentioning
Bisphenol A (BPA) exposure has been documented in pregnant women, but consequences for development are not yet widely studied in human populations. This review presents research on the consequences for offspring of BPA exposure during pregnancy. Extensive work in laboratory rodents has evaluated survival and growth of the conceptus, interference with embryonic programs of development, morphological sex differentiation, sex differentiation of the brain and behavior, immune responsiveness, and mechanism of action. Sensitive measures include RAR, aryl hydrocarbon receptor, and Hox A10 gene expression, anogenital distance, sex differentiation of affective and exploratory behavior, and immune hyperresponsiveness. Many BPA effects are reported at low doses (10-50 µg/kg d range) by the oral route of administration. At high doses (>500,000 µg/kg d) fetal viability is compromised. Much of the work has centered around the implications of the estrogenic actions of this agent. Some work related to thyroid mechanism of action has also been explored. BPA research has actively integrated current knowledge of developmental biology, concepts of endocrine disruption, and toxicological research to provide a basis for human health risk assessment.
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