Disposition Kinetics of Ropivacaine in Humans

Abstract

Disposition kinetics of ropivacaine in humans. Anesth Analg 1989;69:7364 The pharrnacokinetic characteristics of a new local anesthetic drug, ropivacaine, were determined after intravenous infusion of 50 mg of the hydrochloride salt into six healthy male volunteers. Results showed that the disposition of ropivacaine can be described by a biexponential function. Its blood clearance (0.72 2 0.16 Llmin) is intermediate between that of mepivacaine and bupivacaine. Plasma binding averaged 94% * 1 % and the volume of distribution at steady sfate based on blood drug concentration was 59 * 7 L. The terminal elimination half-life was 211 ? 62 min.

Clinical efficacy and pharmacokinetics of 1% ropivacaine and 0.75% bupivacaine in peribulbar anaesthesia for cataract surgery

“…Bupivacaine has a higher n-heptane buffer partition coefficient and, consequently, a greater volume of distribution and a greater propensity to accumulate in fat and nerve tissue compared with ropivacaine [22,23]. It may well be that the adipose tissue in the orbital space acted as a reservoir for the more lipophilic bupivacaine, slowing down its systemic release.…”

No Difference in Early Analgesia Between Liposomal Bupivacaine Injection and Intrathecal Morphine After TKA

“…These cocktails have been shown to be effective in the acute perioperative period but have finite periods of action. Traditional amide local anesthetics such as bupivacaine or ropivacaine (which is reported to have a faster onset than bupivacaine but with a similar duration of action [2,7,11,12,22,25,37,41,50,52,55,58,74,86]) have been the mainstay of most TKA PAI cocktails. In addition to amide local anesthetics, some investigators have chosen to also include intrathecal morphine as part of their pain management protocol.…”

Plasma concentrations of ropivacaine given with or without epinephrine for brachial plexus block

“…Plasma protein binding is high, 94 per cent, and most of the binding is accounted for by association with c~-acid glycoprotein. 5 The main objective of this study was to assess the anaesthetic characteristics and pharmacokinetic properties of 0.5 per cent ropivacaine with or without epinephrine when used for brachial plexus anaesthesia in patients undergoing orthopaedic surgery. The clinical results of the study were reported separately 6 and this report provides information on the plasma concentrations of ropivacaine that were produced.…”