1977
DOI: 10.1007/bf03189310
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Disposition kinetics of barbital in hamsters with hereditary heart failure

Abstract: Within a few minutes after oral administration of sodium barbital, 100 mg/kg, in hamsters with hereditary heart failure, the concentration of the drug was found to be lower in the plasma, kidney, brain and striated muscle of these animals than in the tissue of control hamsters. This could be explained by delayed intestinal absorption, as evidenced by greater amounts of drug recovered from the intestine of cardiomyopathic animals a few minutes after barbital administration. However, 6-24 hours later, the concen… Show more

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