Disposition, behavioural and physiological effects of escalating doses of intravenously administered fentanyl to young foals

Knych, Heather K; Steffey, Eugene; Casbeer, H. C.; Mitchell, M. M.

doi:10.1111/evj.12318

Cited by 15 publications

(9 citation statements)

References 18 publications

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“…In preclinical settings, specific strains of rats (Lai & Lui, 2000;Weinger et al, 1995), rabbits (Soares et al, 2014), and guinea pigs (Brent & Bot, 1992) developed opioid-induced muscle rigidity and were considered potential translational animal models in relevant research fields. Furthermore, this phenomenon has been reported in other animal species as well, including equids (Knych et al, 2015) and elk (Paterson et al, 2009). Here, we describe the rare case of a Terumo Corporation, Tokyo, Japan) was infused intravenously (5-8 ml kg −1 h −1 ) through the cephalic vein.…”

Section: Introductionmentioning

confidence: 67%

Fentanyl‐induced muscle rigidity in a dog during weaning from mechanical ventilation after emergency abdominal surgery: A case report

Sasaki

Rabozzi²,

Kasai

et al. 2022

Veterinary Medicine & Sci

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A 22.5‐kg, 8.4‐year‐old female mixed breed dog was presented for an emergency ovariohysterectomy for pyometra. No neurological abnormalities were observed on preoperative physical examination. Surgery was completed uneventfully under fentanyl‐ and sevoflurane‐based anaesthesia. Cardiorespiratory indices remained stable under mechanical ventilation throughout the procedure. Approximately 23 min after the discontinuation of fentanyl infusion, the investigator noticed jaw closure and stiffness and thoraco‐abdominal muscle rigidity. To rule out fentanyl‐induced muscle rigidity, naloxone was administered. Following administration of naloxone, there was a return of spontaneous respiratory effort, indicated by capnogram and visible chest wall excursion. Based on the clinical signs and response to naloxone administration, the dog was diagnosed with suspected fentanyl‐induced muscle rigidity. Six minutes after the return of spontaneous respiration, the dog was extubated uneventfully without additional naloxone administration. During 4 days of postoperative hospitalization, no recurrent muscle rigidity was observed, and the patient was discharged safely. The total dose of fentanyl administered was 0.61 mg (27 μg kg −1 ).

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Section: Introductionmentioning

confidence: 67%

Fentanyl‐induced muscle rigidity in a dog during weaning from mechanical ventilation after emergency abdominal surgery: A case report

Sasaki

Rabozzi²,

Kasai

et al. 2022

Veterinary Medicine & Sci

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“…Results of clinical investigations into the effectiveness of opioid analgesia varied significantly depending on the individual horse and level of pain, with horses also showing greater variability than other species (Rowland et al, 2014). Clinical studies have also seen variations resulting from age, and some research has been conducted into the effect of some genetic variations on opioid metabolism (Knych et al, 2015; Ohta et al, 2010; Sanchez et al, 2007; Wetmore et al, 2016). Currently, the most common opioid used in equine practice is butorphanol, with morphine, fentanyl and methadone also systemically administered (Robertson et al, 2014).…”

Section: Opioids In Equine Practicementioning

confidence: 99%

Melanocortin‐1 receptor influence in equine opioid sensitivity

Bacon

Donnelly

Finno

et al. 2022

Equine Veterinary Education

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Summary Individual variation in opioid sensitivity can have a profound impact on the safety and efficacy of equine veterinary treatments, with the ability to adequately manage equine pain in a clinical setting currently limited. This review aims to explore the overlap between biological mechanisms associated with opioid metabolism and those mechanisms associated with coat colour in horses as has been documented in humans, with particular focus on the melanocortin‐1 receptor (MC1R) gene. In the future, the use of the MC1R coat colour genotype could help to indicate variable opioid sensitivities thereby greatly improving the use of opioids in clinical settings. The MC1R gene has a well‐established role in melanogenesis and pigment switching, but involvement in the pain‐modulating periaqueductal grey (PAG) descending pathway and in immune responses, both of which contain opioid receptors, has also been suggested in humans. However, this relationship between opioid metabolism and the connection to the three known MC1R variants (EE, Ee and Eea) in horses is yet to be explored.

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“…It was shown that compound ( 138 ) affected the behavior of mice in the open field test by reducing the speed and distance of movement but did not significantly influence the research activity of animals [ 79 ]. This inhibitory effect on the motor activity of animals is characteristic of opioid analgesics [ 83 , 84 ] and analgesics, which affect the cannabinoid system, such as ∆ 9 -tetrahydrocannabinol [ 85 ]. To identify a possible mode of action, researchers studied the effect of the nonselective opioid receptor antagonist naloxone [ 86 ] and the selective cannabinoid CB1 receptor antagonist rimonabant [ 87 ] on the analgesic activity of compound ( 138 ) in the acetic acid-induced writhing test.…”

Section: Effect Of Azaadamantans On the Nervous Systemmentioning

confidence: 99%

Azaadamantanes, a New Promising Scaffold for Medical Chemistry

et al. 2021

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Azaadamantanes are nitrogen-containing analogs of adamantane, which contain one or more nitrogen atoms instead of carbon atoms. This substitution leads to several specific chemical and physical properties. The azaadamantane derivatives have less lipophilicity compared to their adamantane analogs, which affects both their interaction with biological targets and bioavailability. The significant increase in the number of publications during the last decade (2009–2020) concerning the study of reactivity and biological activity of azaadamantanes and their derivatives indicates a great theoretical and practical interest in these compounds. Compounds with pronounced biological activity have been already discovered among azaadamantane derivatives. The review is devoted to the biological activity of azaadamantanes and their derivatives. It presents the main methods for the synthesis of di- and triazaadamantanes and summarizes the accumulated data on studying the biological activity of these compounds. The prospects for the use of azaadamantanes in medical chemistry and pharmacology are discussed.

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Disposition, behavioural and physiological effects of escalating doses of intravenously administered fentanyl to young foals

Abstract: Behavioural and physiological responses to i.v. fentanyl in young foals are dose related. As with mature horses, the window of fentanyl plasma concentrations related to possible clinically desirable actions appears relatively narrow.

Cited by 15 publications

References 18 publications

Fentanyl‐induced muscle rigidity in a dog during weaning from mechanical ventilation after emergency abdominal surgery: A case report

Fentanyl‐induced muscle rigidity in a dog during weaning from mechanical ventilation after emergency abdominal surgery: A case report

Melanocortin‐1 receptor influence in equine opioid sensitivity

Azaadamantanes, a New Promising Scaffold for Medical Chemistry

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